Primenenie kombinirovannykh oral'nykh kontratseptivov u zhenshchin reproduktivnogo vozrasta s ozhireniem
https://doi.org/10.14341/2071-8713-5310
Abstract
This article assesses the problem of obesity as a risk factor for development of severe metabolic complications and different disorders of reproductive function in women of childbearing age. It is pointed that obesity is associated with high prevalence of hyperandrogenemic and hyperplastic disorders, polycystic ovary syndrome, infertility, complications of pregnancy and childbirth. Article discusses the questions of integrated treatment approach of this category of patients, which include non-drug interventions (rational nutrition, lifestyle modification) as well as the use of medications which lower the insulin resistance and hyperinsulinemia to restore ovary function and the possible use of combined oral contraceptives for correction of anovulation.
References
1. Теппермен Д., Теппермен Х. Физиология обмена веществ и эндокринной системы. М.: Мир. 1989. Гл.12. с. 372 - 97.
2. Йен С. С. К., Джаффе Р. Б. Репродуктивная эндокринология. М.: Медицина.1998 г. Т. 1, с. 228.
3. Clark A. M., Thornley B., Tomlinson L., Galletley C., Norman R. J. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13: 1502-5.
4. Col V. New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism. // Rev. Assoc. Belge technol. lab. - 2002. - v. 29. - № 1. - p. 9-19.
5. Marterns J.W.M., Geller D.H., Arlt W., Auchus R.J., Ossovskaaya V.S., Rodrigues H., Dunaif F., Miller W.L.. Enzymatic Activities of P450c17 Stably Expressed in Fibroblasts from Patients with the Polycystic Ovary Syndrome. // J. Clin. Endocrinol. and Metab. - 2000 Novembrer - v. 85 - № 11 - p. 4338-4352.
6. Norman R. J., Clark A. M. Lifestyle factors in the aetiology and management of polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Edited by Gabor T. Kovacs. Cambridge University Press 2000; 98-116.
7. Pehlivanov B. Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome / Pehlivanov B., Mitkov M. // Eur. Contracept. Reprod. Health. Care. - 2007. - Vol.12. - N1. - P. 30-35.
8. van Vloten W.A. Selecting an oral contraceptiveagent for the treatment of acne in women / van Vloten W.A., Sigurdsson V. // Am. J. Clin. Dermatol. - 2004. - Vol. 6. - N5. - P. 435-441.
Review
For citations:
, , , Primenenie kombinirovannykh oral'nykh kontratseptivov u zhenshchin reproduktivnogo vozrasta s ozhireniem. Obesity and metabolism. 2009;6(2):3-6. (In Russ.) https://doi.org/10.14341/2071-8713-5310
Views:
729
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
