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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-5310</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-5310</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Применение комбинированных оральных контрацептивов у женщин репродуктивного возраста с ожирением</article-title><trans-title-group xml:lang="en"><trans-title>Primenenie kombinirovannykh oral'nykh kontratseptivov u zhenshchin reproduktivnogo vozrasta s ozhireniem</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Andreeva</surname><given-names>E N</given-names></name></name-alternatives><email xlink:type="simple">endogin@mail.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Karpova</surname><given-names>E A</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Andreeva</surname><given-names>E N</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Karpova</surname><given-names>E</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2009</year></pub-date><volume>6</volume><issue>2</issue><issue-title>№2 (2009)</issue-title><fpage>3</fpage><lpage>6</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Andreeva E.N., Karpova E.A., Andreeva E.N., Karpova E., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Andreeva E.N., Karpova E.A., Andreeva E.N., Karpova E.</copyright-holder><copyright-holder xml:lang="en">Andreeva E.N., Karpova E.A., Andreeva E.N., Karpova E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/5310">https://www.omet-endojournals.ru/jour/article/view/5310</self-uri><abstract><p>В статье рассматривается проблема ожирения как фактора риска развития тяжелых метаболических нарушений и различных нарушений репродуктивной функции у женщин детородного возраста. Указывается на высокую частоту гиперандрогенных состояний, гиперпластических процессов, СПЯ, бесплодия, осложнений течения беременности и родов. Обсуждаются вопросы комплексного лечения данной категории пациенток, включающего как немедикаментозные мероприятия (рациональное питание, модификация образа жизни), так и назначение лекарственных препаратов, уменьшающих инсулинорезистентность и гиперинсулинемию с целью восстановления функции яичников, а также возможность применения комбинированных оральных контрацептивов для устранения ановуляции.
            </p></abstract><trans-abstract xml:lang="en"><p>This article assesses the problem of obesity as a risk factor for development of severe metabolic complications and different disorders of reproductive function in women of childbearing age. It is pointed that obesity is associated with high prevalence of hyperandrogenemic and hyperplastic disorders, polycystic ovary syndrome, infertility, complications of pregnancy and childbirth. Article discusses the questions of integrated treatment approach of this category of patients, which include non-drug interventions (rational nutrition, lifestyle modification) as well as the use of medications which lower the insulin resistance and hyperinsulinemia to restore ovary function and the possible use of combined oral contraceptives for correction of anovulation.
            </p></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперандрогения</kwd><kwd>СПЯ</kwd><kwd>ановуляция</kwd><kwd>ожирение</kwd><kwd>контрацептивы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hyperandrogenemia</kwd><kwd>PCOS</kwd><kwd>anovulation</kwd><kwd>obesity</kwd><kwd>contraceptives</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Теппермен Д., Теппермен Х. Физиология обмена веществ и эндокринной системы. М.: Мир. 1989. Гл.12. с. 372 - 97.</mixed-citation><mixed-citation xml:lang="en">Теппермен Д., Теппермен Х. Физиология обмена веществ и эндокринной системы. М.: Мир. 1989. Гл.12. с. 372 - 97.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Йен С. С. К., Джаффе Р. Б. Репродуктивная эндокринология. М.: Медицина.1998 г. Т. 1, с. 228.</mixed-citation><mixed-citation xml:lang="en">Йен С. С. К., Джаффе Р. Б. Репродуктивная эндокринология. М.: Медицина.1998 г. Т. 1, с. 228.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Clark A. M., Thornley B., Tomlinson L., Galletley C., Norman R. J. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13: 1502-5.</mixed-citation><mixed-citation xml:lang="en">Clark A. M., Thornley B., Tomlinson L., Galletley C., Norman R. J. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13: 1502-5.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Col V. New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism. // Rev. Assoc. Belge technol. lab. - 2002. - v. 29. - № 1. - p. 9-19.</mixed-citation><mixed-citation xml:lang="en">Col V. New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism. // Rev. Assoc. Belge technol. lab. - 2002. - v. 29. - № 1. - p. 9-19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Marterns J.W.M., Geller D.H., Arlt W., Auchus R.J., Ossovskaaya V.S., Rodrigues H., Dunaif F., Miller W.L.. Enzymatic Activities of P450c17 Stably Expressed in Fibroblasts from Patients with the Polycystic Ovary Syndrome. // J. Clin. Endocrinol. and Metab. - 2000 Novembrer - v. 85 - № 11 - p. 4338-4352.</mixed-citation><mixed-citation xml:lang="en">Marterns J.W.M., Geller D.H., Arlt W., Auchus R.J., Ossovskaaya V.S., Rodrigues H., Dunaif F., Miller W.L.. Enzymatic Activities of P450c17 Stably Expressed in Fibroblasts from Patients with the Polycystic Ovary Syndrome. // J. Clin. Endocrinol. and Metab. - 2000 Novembrer - v. 85 - № 11 - p. 4338-4352.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Norman R. J., Clark A. M. Lifestyle factors in the aetiology and management of polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Edited by Gabor T. Kovacs. Cambridge University Press 2000; 98-116.</mixed-citation><mixed-citation xml:lang="en">Norman R. J., Clark A. M. Lifestyle factors in the aetiology and management of polycystic ovary syndrome. In: Polycystic Ovary Syndrome. Edited by Gabor T. Kovacs. Cambridge University Press 2000; 98-116.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pehlivanov B. Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome / Pehlivanov B., Mitkov M. // Eur. Contracept. Reprod. Health. Care. - 2007. - Vol.12. - N1. - P. 30-35.</mixed-citation><mixed-citation xml:lang="en">Pehlivanov B. Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome / Pehlivanov B., Mitkov M. // Eur. Contracept. Reprod. Health. Care. - 2007. - Vol.12. - N1. - P. 30-35.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">van Vloten W.A. Selecting an oral contraceptiveagent for the treatment of acne in women / van Vloten W.A., Sigurdsson V. // Am. J. Clin. Dermatol. - 2004. - Vol. 6. - N5. - P. 435-441.</mixed-citation><mixed-citation xml:lang="en">van Vloten W.A. Selecting an oral contraceptiveagent for the treatment of acne in women / van Vloten W.A., Sigurdsson V. // Am. J. Clin. Dermatol. - 2004. - Vol. 6. - N5. - P. 435-441.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
