Physiology of calcium metabolism in kidneys
https://doi.org/10.14341/2071-8713-5296
Abstract
and excitation-contraction coupling and cell fertilization. There are various forms of calcium in the body: ionized, complexed and
protein bound, and only two first forms can be filtered at the glomerulus and cross cell membranes. The present review covers the topics
of physiology, regulation and pathogenesis of disturbances of renal calcium metabolism.
References
1. Мирная С.С., Пигарова Е.А., Мокрышева Н.Г., Беляева А.В. Тюльпаков А.Н., Рожинская Л.Я. Роль кальций-чувствительного рецептора в поддержании системы кальциевого гомеостаза // Остеопороз и остеопатии. - 2010. - № 3 (24). - С. 28-33.
2. Alpern R.J., Hebert S.C. Seldin and Giebisch's The Kidney (4th edition) // Academic Press. - 2007. - Р. 1851-1890.
3. Benos D.J., Awayda M.S., Ismailov I.I., Johnson J.P. Structure and function of amiloridesensitive Na+ channels // J Membr Biol. - 1995 Jan. - № 143 (1). - Р. 1-18.
4. Berndt T.J., Knox F.G. Effects of parathyroid hormone and calcitonin on electrolyte excretion in the rabbit // Kidney Int. - 1980 Apr. - № 17 (4). - Р. 473-8.
5. Berner Y.N., Shike M. Consequences of phosphate imbalance // Annu Rev Nutr. - 1988. - № 8. - Р. 121-48.
6. Boland P.S., Garland H.O. Effects of D-glucose, L-glucose and D-mannitol on renal calcium handling and general renal function in the rat // Exp Physiol. - 1993 Mar. - № 78 (2). - Р. 165-74.
7. Brown E.M., Hebert S.C. A cloned Ca(2+)-sensing receptor: a mediator of direct effects of extracellular Ca2+ on renal function? // J Am Soc Nephrol. - 1995. - № 6 (6). - Р. 1530-40.
8. Brunette M.G., Leclerc M. Effect of estrogen on calcium and sodium transport by the nephron luminal membranes // J Endocrinol. - 2001 Aug. - № 170 (2). - Р. 441-50.
9. Brunette M.G., Leclerc M. Renal action of progesterone: effect on calcium reabsorption // Cell Endocrinol. - 2002 Aug 30. - № 194 (1-2). - Р. 183-90.
10. Burnatowska M.A., Harris C.A., Sutton R.A., Seely J.F. Effects of vitamin D on renal handling of calcium, magnesium and phosphate in the hamster // Kidney Int. - 1985 Jun. - № 27 (6). - Р. 864-70.
11. Couchourel D., Leclerc M., Filep J., Brunette M.G. Testosterone enhances calcium reabsorption by the kidney // Mol Cell Endocrinol. - 2004 Jul 30. - № 222 (1-2). - Р. 71-81.
12. Di Stefano A., Elalouf J.M., Garel J.M., de Rouffignac C. Modulation by calcitonin of magnesium and calcium urinary excretion in the rat // Kidney Int. - 1985 Feb. - № 27 (2). - Р. 394-400.
13. Dimke H., Hoenderop J.G., Bindels R.J. Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family // J Physiol. - 2011 Apr 1. - № 589 (Pt 7). - Р. 1535-42.
14. Friedman P.A. Calcium transport in the kidney. Current Opinion in Nephrology & Hypertension // 1999. - 8 (5). - Р. 589-595.
15. Friedman P.A. Renal Calcium Transport: Sites and Insights // Physiology February. - 1988. - V. 3 (1). - P. 17-20.
16. Garty H., Benos D.J. Characteristics and regulatory mechanisms of the amilorideblockable Na+ channel // Physiol Rev. - 1988 Apr. - № 68 (2). - Р. 309-73.
17. Gesek F.A., Friedman P.A. Calcitonin stimulates calcium transport in distal convoluted tubule cells // Am J Physiol. - 1993 Apr. - № 264 (4 Pt 2). - Р. F744-51.
18. Gesek F.A., Friedman P.A. Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells // J Clin Invest. - 1992 Aug. - № 90 (2). - Р. 429-38.
19. Gesek F.A., Friedman P.A. On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule cells // J Clin Invest. - 1992 Sep. - № 90 (3). - Р. 749-58.
20. Graziani G., Fedeli C., Moroni L., Cosmai L., Badalamenti S., Ponticelli C. Gitelman syndrome: pathophysiological and clinical aspects // QJM. - 2010 Oct. - № 103 (10). - Р. 741-8.
21. Guarnieri V., Canaff L., Yun F.H., Scillitani A., Battista C., Muscarella L.A., Wong B.Y., Notarangelo A., D'Agruma L., Sacco M., Cole D.E., Hendy G.N. Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years // J Clin Endocrinol Metab. - 2010 Apr. - № 95 (4). - Р. 1819-29.
22. Halperin M.L., Cheema Dhadli S., Kamel K.S. Physiology of acid-base balance: links with kidney stone prevention // Semin Nephrol. - 2006 Nov. - № 26 (6). - Р. 441-6.
23. Iida K., Shinki T., Yamaguchi A., DeLuca H.F., Kurokawa K., Suda T. A possible role of vitamin D receptors in regulating vitamin D activation in the kidney // Proc Natl Acad Sci U S A. - 1995 Jun 20. - № 92 (13). - Р. 6112-6.
24. Jeong J.H., Bae E.H. Hypercalcemia associated with acute kidney injury and metabolic alkalosis // Electrolyte Blood Press. - 2010 Dec. - № 8 (2). - Р. 92-4.
25. Knoers N.V., Levtchenko E.N. Gitelman syndrome // Orphanet J Rare Dis. - 2008 Jul 30. - № 3. - Р. 22.
26. Laing C.M., Toye A.M., Capasso G., Unwin R.J. Renal tubular acidosis: developments in our understanding of the molecular basis // Int J Biochem Cell Biol. - 2005 Jun. - № 37 (6). - Р. 1151-61.
27. Leclerc M., Brunette M.G., Couchourel D. Aldosterone enhances renal calcium reabsorption by two types of channels // Kidney Int. - 2004 Jul. - № 66 (1). - Р. 242-50.
28. Lee C.T., Chen H.C., Lai L.W., Yong K.C., Lien Y.H. Effects of furosemide on renal calcium handling // Am J Physiol Renal Physiol. - 2007 Oct. - № 293 (4). - Р. F1231-7.
29. Lee C.T., Shang S., Lai L.W., Yong K.C., Lien Y.H. Effect of thiazide on renal gene expression of apical calcium channels and calbindins // Am J Physiol Renal Physiol. - 2004 Dec. - № 287 (6). - Р. F1164-70.
30. Lee M., Partridge N.C. Parathyroid hormone signaling in bone and kidney // Curr Opin Nephrol Hypertens. - 2009 Jul. - № 18 (4). - Р. 298-302.
31. Loffing J., Loffing-Cueni D., Valderrabano V., Kläusli L., Hebert S.C., Rossier B.C.,
32. Hoenderop J.G., Bindels R.J., Kaissling B. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron // Am J Physiol Renal Physiol. - 2001 Dec. - № 281 (6). - Р. F1021-7.
33. Markadieu N., Bindels R.J., Hoenderop J.G. The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport // Int J Biochem Cell Biol. - 2011 Jan. - № 43 (1). - Р. 1-4.
34. Messa P., Alfieri C., Rastaldi M.P. Recent insights into vitamin D and its receptor // J Nephrol. - 2011 May-Jun. - № 24 Suppl 18. - Р. S30-7. 34. Stefíková K., Spustová V., Dzúrik R. Acute effect of hydrochlorothiazide on renal calcium and magnesium handling in postmenopausal women // Physiol Res. - 1999. - № 48 (4). - Р. 327-30.
35. Suda T., Shinki T., Kurokawa K. The mechanisms of regulation of vitamin D metabolism in the kidney // Curr Opin Nephrol Hypertens. - 1994 Jan. - № 3 (1). - Р. 59-64.
36. Usdin T.B., Bonner T.I., Harta G., Mezey E. Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat // Endocrinology. - 1996 Oct. - № 137 (10). - Р. 4285-97.
37. Van Abel M., Hoenderop J.G., van der Kemp A.W., Friedlaender M.M., van Leeuwen J.P., Bindels R.J. Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone // Kidney Int. - 2005 Oct. - № 68 (4). - Р. 1708-21.
38. Wong P.S., Barclay P.L., Newman M.J., Johns E.J. The influence of acetazolamide and amlodipine on the intracellular sodium content of rat proximal tubular cells // Br J Pharmacol. - 1994 Jul. - № 112 (3). - Р. 881-6.
Review
For citations:
Physiology of calcium metabolism in kidneys. Obesity and metabolism. 2011;8(4):3-8. (In Russ.) https://doi.org/10.14341/2071-8713-5296

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).