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Parametry metabolizma i gemostazapri endogennom giperkortitsizme s narusheniemuglevodnogo obmena

https://doi.org/10.14341/2071-8713-4833

Abstract

The aim of the study was to determine peculiarities of protein and lipid metabolism as well as platelet-coagulation hemostasis
depending on the pathogenesis of the endogenous hypercortisolism and assessment of the impact of chronic hyperglycemia
on studied parameters. Materials and methods. The study included 19 patients with pituitary microadenomas with median age of
45,0 (41; 49) years and 9 patients with nodular adrenal gland hyperplasia aged 49,5 (42; 57) years, 14 of whom had diabetes mellitus.
Results. Biochemical and coagulation parameters in patients with endogenous hyperpercortisolism regardless of ethiology Cushing`s
syndrome differed from the control group in increased concentration of total cholesterol, high-density lipoproteins, low-density
lipoproteins, alpha2-globulins and decreased gamma globulins, as well as in increased average volume of platelets and enhanced aggregation
properties. Carbohydrate metabolism disorders were not characterized by significant differences in metabolic parameters
and platelet hemostasis, but were accompanied by the reduction of APTT.

About the Authors

G Petrik



S Pavlishchuk



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For citations:


 ,   Parametry metabolizma i gemostazapri endogennom giperkortitsizme s narusheniemuglevodnogo obmena. Obesity and metabolism. 2011;8(3):26-29. (In Russ.) https://doi.org/10.14341/2071-8713-4833

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ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)