Pathophysiologic interrelationships of metabolic syndrome and gut microbiota
https://doi.org/10.14341/omet13097
Abstract
The problem of obesity and metabolic syndrome is becoming increasingly global in the modern world. The social and environmental factors that play a role in the development of these conditions are not yet fully understood, but there is already accumulating evidence that the development of obesity and metabolic syndrome is promoted by unfavorable conditions in early life, such as maternal diseases during pregnancy and lactation, the use of various chemical and medicinal agents, low birth weight of the fetus, and unfavorable dietary patterns and quality of nutrition. All these factors have their impact on the gastrointestinal tract, particularly leading to an imbalance of the intestinal microflora. Evidence is accumulating that the gut microbiome of obese people is structurally and functionally different from the gut microflora of healthy people. The identification of a strong correlation between these parameters may offer prospects for the prevention of metabolic syndrome and all associated conditions by maintaining the health of the gut microflora. The aim of this article is to highlight the data from animal and human studies that confirm the presence of pathophysiological mechanisms of the influence of the intestinal microflora on the development of obesity and the associated metabolic syndrome, and to search for opportunities to prevent these conditions through the addition of pre- and probiotics to food.
About the Authors
A. V. Klimchuk
Order of the Red Banner of Labor S. I. Georgievsky Medical Institute V. I. Vernadsky Crimean Federal University
Russian Federation
Competing Interests:
Russian Federation
Anastasia V. Klimchuk, Associate Professor, Department of Internal Medicine No. 2
Simferopol
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи
I. A. Yatskov
Order of the Red Banner of Labor S. I. Georgievsky Medical Institute V. I. Vernadsky Crimean Federal University
Russian Federation
Competing Interests:
Russian Federation
Igor A. Yatskov, PhD, Associate Professor, Department of Internal Medicine No. 2
295051, Lenin boulevard 5/7, Simferopol
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи
D. V. Kritskaya
Order of the Red Banner of Labor S. I. Georgievsky Medical Institute V. I. Vernadsky Crimean Federal University
Russian Federation
Competing Interests:
Russian Federation
Daria V. Kritskaya, Student, Department of Internal Medicine No. 2
Scopus Author ID: 1233361
Simferopol
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи
E. O. Ivashkova
Order of the Red Banner of Labor S. I. Georgievsky Medical Institute V. I. Vernadsky Crimean Federal University
Russian Federation
Competing Interests:
Russian Federation
Ekaterina O. Ivashkova, Student, Department of Internal Medicine No. 2
Simferopol
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи
P. S. Konovalova
FGBU "State Research Center RF FMBC named after A.I. Burnazyan"
Russian Federation
Competing Interests:
Russian Federation
Polina S. Konovalova, Resident of the Department of Internal Medicine
Moscow
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи
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Klimchuk A.V., Yatskov I.A., Kritskaya D.V., Ivashkova E.O., Konovalova P.S. Pathophysiologic interrelationships of metabolic syndrome and gut microbiota. Obesity and metabolism. 2025;22(3):222-228. (In Russ.) https://doi.org/10.14341/omet13097
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