ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13097ometendo-13097Research ArticleОБЗОРЫREVIEWSПатофизиологические взаимосвязи метаболического синдрома и микробиоты кишечникаPathophysiologic interrelationships of metabolic syndrome and gut microbiotahttps://orcid.org/0000-0003-1577-7077КлимчукА. В.KlimchukA. V.

Климчук Анастасия Васильевна, к.м.н., доцент кафедры внутренней медицины №2

Симферополь

Anastasia V. Klimchuk, Associate Professor, Department of Internal Medicine No. 2

Simferopol

anastasiya-klim@mail.ruhttps://orcid.org/0009-0007-1828-5496КрицкаяД. В.KritskayaD. V.

Крицкая Дарья Владимировна, студентка кафедры внутренней медицины №2

Scopus Author ID: 1233361

Симферополь

Daria V. Kritskaya, Student, Department of Internal Medicine No. 2

Scopus Author ID: 1233361

Simferopol

dari.kritccc@gmail.comhttps://orcid.org/0009-0001-8235-7315ИвашковаЕ. О.IvashkovaE. O.

Ивашкова Екатерина Олеговна, студентка кафедры внутренней медицины №2

Симферополь

Ekaterina O. Ivashkova, Student, Department of Internal Medicine No. 2

Simferopol

ivashkova.catya@yandex.ruhttps://orcid.org/0000-0001-5175-4468КоноваловаП. С.KonovalovaP. S.

Коновалова Полина Сергеевна, ординатор кафедры терапии

Москва

 

Polina S. Konovalova, Resident of the Department of Internal Medicine

Moscow

ponyllin@bk.ruhttps://orcid.org/0000-0002-5486-7262ЯцковИ. А.YatskovI. A.

Яцков Игорь Анатольевич, к.м.н., доцент кафедры внутренней медицины №2

Scopus Author ID:  57218873902

295051, Симферополь, бульвар Ленина 5/7 

Igor A. Yatskov, PhD, Associate Professor, Department of Internal Medicine No. 2

295051, Lenin boulevard 5/7, Simferopol

egermd@yandex.ruОрдена Трудового Красного Знамени Медицинский Институт имени С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет имени В. И. Вернадского»РоссияOrder of the Red Banner of Labor S. I. Georgievsky Medical Institute V. I. Vernadsky Crimean Federal UniversityRussian FederationФГБУ «ГНЦ РФ ФМБЦ им. А.И. Бурназяна»РоссияFGBU "State Research Center RF FMBC named after A.I. Burnazyan"Russian Federation202509122025223222228Copyright © Климчук А.В., Крицкая Д.В., Ивашкова Е.О., Коновалова П.С., Яцков И.А., 20252025Климчук А.В., Крицкая Д.В., Ивашкова Е.О., Коновалова П.С., Яцков И.А.Klimchuk A.V., Kritskaya D.V., Ivashkova E.O., Konovalova P.S., Yatskov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13097

В условиях современного мира все глобальнее становится проблема ожирения и метаболического синдрома. Социальные и экологические факторы, играющие роль в развитии этих состояний, еще не до конца изучены, однако уже сейчас накапливаются данные, свидетельствующие о том, что развитию ожирения и метаболического синдрома способствуют неблагоприятные условия раннего периода жизни, например, заболевания матери в периоды беременности и лактации, использование различных химических и лекарственных агентов, низкая масса плода при рождении, неблагоприятные режим и качество питания. Все эти факторы оказывают воздействие на состояние желудочно-кишечного тракта, в частности приводят к дисбалансу кишечной микрофлоры. Накапливаются данные о том, что микробиом кишечника людей с ожирением структурно и функционально отличен от микрофлоры кишечника здорового человека. Выявление прочной корреляционной связи между этими параметрами может открыть перспективы для профилактики метаболического синдрома и всех ассоциированных с ним состояний путем поддержания здоровья кишечной микрофлоры. Целью данной статьи является освещение данных исследований, проводимых на животных и людях, которые подтверждают наличие патофизиологических механизмов влияния кишечной микрофлоры на развитие ожирения и сопутствующего метаболического синдрома, а также поиск возможностей профилактики данных состояний посредством добавления пре- и пробиотиков к пище.

The problem of obesity and metabolic syndrome is becoming increasingly global in the modern world. The social and environmental factors that play a role in the development of these conditions are not yet fully understood, but there is already accumulating evidence that the development of obesity and metabolic syndrome is promoted by unfavorable conditions in early life, such as maternal diseases during pregnancy and lactation, the use of various chemical and medicinal agents, low birth weight of the fetus, and unfavorable dietary patterns and quality of nutrition. All these factors have their impact on the gastrointestinal tract, particularly leading to an imbalance of the intestinal microflora. Evidence is accumulating that the gut microbiome of obese people is structurally and functionally different from the gut microflora of healthy people. The identification of a strong correlation between these parameters may offer prospects for the prevention of metabolic syndrome and all associated conditions by maintaining the health of the gut microflora. The aim of this article is to highlight the data from animal and human studies that confirm the presence of pathophysiological mechanisms of the influence of the intestinal microflora on the development of obesity and the associated metabolic syndrome, and to search for opportunities to prevent these conditions through the addition of pre- and probiotics to food.

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The authors declare that there are no conflicts of interest present.