Vol 9, No 1 (2012)
Articles
3-8 1026
Abstract
Ghrelin is an endogenous ligand for growth hormone receptor, which is synthesized as a prohormone, and then proteolytically converted into 28-amino acid peptide. This peptide stimulates the secretion of growth hormone, regulates food intake, effect on carbohydrate and lipid metabolism. Ghrelin enhances the bioavailability of nitric oxide and maintains the balance between endothelin-1 and nitric oxide in the vascular wall. It increases cardiac output, and reduces blood pressure and systemic vascular resistance. Antiinflammatory effect of ghrelin is also appreciated. Since ghrelin is a circulating peptide that stimulates appetite and regulate energy balance, and its role in the development of obesity and type 2 diabetes it is the subject of intense research. A variety of metabolic functions of ghrelin requires extreme caution in the use of therapeutic approaches aimed at the stimulation or blockade of its action.
9-13 636
Abstract
The review presents a contemporary data concerning the use of tamoxifen in wide range of pathological conditions: central nervous system diseases and mechanisms of neuroprotective action of estrogen receptors, pituitary tumors with the accent on the treatment of prolactinomas, infertility treatment. We also discuss the risks of tamoxifen treatment for pregnancy induction in women including complications of pregnancy, fetus malformations.
24-28 448
Abstract
The aim of this study was to analyze the corrections of the metabolic syndrome and the liver dysfunction of morbidly obese patients after the biliapancreatic diversion (BPD). All patients were divided into two groups: first group with average BMI 44,6±3,0 and second group with average BMI 53,0±6,7. After BPD the average % excess weight loss (EWL) in the first group was 72,8% and in the second - 53,2%. The corrections of the metabolic syndrome and the liver dysfunction were also better in the first group. The baseline BMI predicts the outcomes after BPD.
29-33 669
Abstract
The aim of our study was to evaluate the levels of nitrite in plasma and methemoglobin in whole blood using electron paramagnetic resonance (EPR) in patients with type 2 diabetes mellitus receiving metformin. After 3 months of continuous use of the drug at a dose of 1700 mg in parallel with the improvement of carbohydrate and lipid metabolism, reduction in waist circumference there was a statistically significant increase in nitrite concentration in plasma and increased methemoglobin in whole blood. Increased bioavailability of nitric oxide during treatment with metformin may be an additional explanation for the mechanism of drug action.
35-41 602
Abstract
Objective: to assess hormonal and metabolic parameters and psychological status of young men with obesity. Methods: The study included 60 men with obesity (BMI>30 kg/m2) divided in two groups. Patients in the first group (n=30) received orlistat for 12 weeks (120 mg 3 times daily with meal). Patients in second group (n=30) followed hypocaloric diet and aerobic exercise. All patients were examined before treatment and after 12 weeks. Evaluation included hormonal and biochemical analyses, 48 patients were examined by psychological questionnaires (Beck Depression Inventory, Beck Anxiety Inventory, Liebowitz Social Anxiety Scale, Dutch Eating Behavior Questionnaire). Results: Patients that received orlistat treatment showed significant decrease of body mass: 50% of patients had decrease more than 5%, 30% of patients - more than 10% (p<0,05). In first group after 12 weeks of treatment level of cortisol decreased and level of testosterone increased. The results of treatment in second group were less significant. There was a significant decrease in anxiety and depression scales in patients taking orlistat (p<0,05). High levels of social anxiety did not decrease in both groups after treatment. As a result of orlistat treatment there was a decrease in external eating behavior and increase in expression of restraint eating behavior by DEBQ (p<0,05). Conclusions: treatment with orlistat reduces body weight, which is correlated by improvement of hormonal and biochemical parameters. Weight loss is accompanied by changes in rates of anxiety and depression.
43-45 529
Abstract
Currently, obesity has taken epidemic proportions, including adolescents. The important components of contemporary therapy of obesity in adolescents are: motivational training, modification of behavioral habits and the adolescent involvement in treatment, the effectiveness of which is demonstrated by this clinical case presentation.
- Bradfield JP,
- Taal HR,
- Timpson NJ,
- Scherag A,
- Lecoeur C,
- Warrington NM,
- Hypponen E,
- Holst C,
- Valcarcel B,
- Thiering E,
- Salem RM,
- Schumacher FR,
- Cousminer DL,
- Sleiman PM,
- Zhao J,
- Berkowitz RI,
- Vimaleswaran KS,
- Jarick I,
- Pennell CE,
- Evans DM,
- St Pourcain B,
- Berry DJ,
- Mook-Kanamori DO,
- Hofman A,
- Rivadeneira F,
- Uitterlinden AG,
- van Duijn CM,
- van der Valk RJ,
- de Jongste JC,
- Postma DS,
- Boomsma DI,
- Gauderman WJ,
- Hassanein MT,
- Lindgren CM,
- Mägi R,
- Boreham CA,
- Neville CE,
- Moreno LA,
- Elliott P,
- Pouta A,
- Hartikainen AL,
- Li M,
- Raitakari O,
- Lehtimäki T,
- Eriksson JG,
- Palotie A,
- Dallongeville J,
- Das S,
- Deloukas P,
- McMahon G,
- Ring SM,
- Kemp JP,
- Buxton JL,
- Blakemore AI,
- Bustamante M,
- Guxens M,
- Hirschhorn JN,
- Gillman MW,
- Kreiner-Møller E,
- Bisgaard H,
- Gilliland FD,
- Heinrich J,
- Wheeler E,
- Barroso I,
- O'Rahilly S,
- Meirhaeghe A,
- Sørensen TI,
- Power C,
- Palmer LJ,
- Hinney A,
- Widen E,
- Farooqi IS,
- McCarthy MI,
- Froguel P,
- Meyre D,
- Hebebrand J,
- Jarvelin MR,
- Jaddoe VW,
- Smith GD,
- Hakonarson H,
SF Grant
49 355
51-57 542
Abstract
The incidence of morbid obesity increases worldwide. Therefore surgical methods of treatment are widely applied. A lot of patients after bariatric surgery requires lifelong control and therapy. The Endocrine Society offered detailed guideline for the management of boost-bariatric surgery patients. The basic recommendations are reviewed in this article.
ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)
ISSN 2306-5524 (Online)
