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Case of insulinoma detected in a patient after bariatric operation for morbid obesity

Abstract

The prevalence of insulinomas is 1–3 cases per million population per year of which 4–14% tumor is malignant. Weight gain is one of the symptoms of the disease, often resulting in morbid obesity with indications for surgical treatment. The presented clinical case demonstrates the successful treatment of malignant insulinoma with the manifestation of hypoglycemic syndrome after carrying out biliopancreatic bypass with longitudinal gastrectomy for morbid obesity.

About the Authors

Ekaterina S. Maloletkina

University Clinical Hospital №2 of "I.M. Sechenov First Moscow State Medical University (Sechenov University)"


Russian Federation

MD, endocrinologist of the endocrinological therapeutic department №2



Olesya Y. Gurova

University Clinical Hospital №2 of "I.M. Sechenov First Moscow State Medical University (Sechenov University)"


Russian Federation

MD, PhD, associate professor of the Department of Endocrinology №1, Faculty of Medicine



Valentin V. Fadeyev

I.M. Sechenov First Moscow State Medical University (Sechenov University)


Russian Federation

MD, ScD, professor, corresponding member of the Russian Academy of Sciences



Vyacheslav I. Egorov

Moscow city hospital № 5 City Clinical Hospital №5 of the Moscow Health Department


Russian Federation

MD, ScD, professor



Roman V. Petrov

Moscow city hospital № 5 City Clinical Hospital №5 of the Moscow Health Department


Russian Federation

MD, PhD, oncologist



Dmitriy G. Beltsevich

Endocrinology Research Center


Russian Federation

MD, ScD, Professor, leading research associate of the surgery department



Andrei V. Vorob'ev

University Clinical Hospital №2 of "I.M. Sechenov First Moscow State Medical University (Sechenov University)"


Russian Federation

MD, endocrinologist, head of the endocrinological therapeutic department №2



References

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5. Malik S, Mitchell JE, Steffen K, et al. Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery. Obes Res Clin Pract. 2016. doi: 10.1016/j.orcp.2015.07.003

6. Mulla CM, Storino A, Yee EU, et al. Insulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches. Obes Surg. 2016;26(4):874-881. doi: 10.1007/s11695-016-2092-5

7. Zagury L, Moreira RO, Guedes EP, et al. Insulinoma Misdiagnosed as Dumping Syndrome after Bariatric Surgery. Obes Surg. 2004;14(1):120-123. doi: 10.1381/096089204772787419

8. Seshadri P, Lenhard MJ, Bennett J, et al. Rare case of insulinoma diagnosed after laparoscopic gastric banding. Surg Obes Relat Dis. 2009;5(1):123-127. doi: 10.1016/j.soard.2008.03.250

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14. Sato T, Narita T, Hosoba M, et al. A case of insulinoma following total gastrectomy—Effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations. Diabetes Res Clin Pract. 2010;88(1):e4-e6. doi: 10.1016/j.diabres.2010.01.006


Supplementary files

1. Таблица 1. Результаты лабораторных и инструментальных исследований на догоспитальном этапе.
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2. Таблица 2. Результаты лабораторных и инструментальных исследований в отдаленном послеоперационном обследовании.
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3. Таблица 3. Дифференциальная диагностика гипогликемий после бариатрических операций (гастрошунтирования), Malik S. et al.
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4. Fig. 1. MSCT of the abdominal cavity with CU. Izovascular formation in the hooked process of the pancreas, lymphadenopathy.
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5. Fig. 2. MSCT frontal plane, tumor of the pancreatic head T2N1M0.
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6. Fig. 3. MSCT frontal plane, pancreatic head tumor.
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7. Fig. 4. Tumor (insulinoma) of the pancreatic head.
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8. Fig. 5. Pancreatoduodenal complex, lymph nodes.
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9. Fig. 6. Magnetic resonance cholangiopancreatography, signs of hepaticojejunostomy stricture (indicated by green arrow)
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Review

For citations:


Maloletkina E.S., Gurova O.Y., Fadeyev V.V., Egorov V.I., Petrov R.V., Beltsevich D.G., Vorob'ev A.V. Case of insulinoma detected in a patient after bariatric operation for morbid obesity. Obesity and metabolism. 2019;16(1):74-80. (In Russ.)

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ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)