Metabolic syndrome in the inhabitants of Mountain Shoria: prevalence, variants of manifestations and ethnic peculiarities

Background. Metabolic syndrome is one of the most dangerous risk factors of cardiovascular and endocrine diseases development and mortality due to them, especially among young people.

Aims: Our purpose was to study the prevalence of the metabolic syndrome, combinations of its components in indigenous and non-indigenous inhabitants of Mountain Shoria.

Materials and methods. During the period since 2012 to 2015 we have examined the inhabitants of the villages of Mountain Shoria: Ust-Kabyrza, Orton, Sheregesh by a continuous method on the basis of a name list. All the participants were examined by a cardiologist, an endocrinologist and a general practitioner, also a waist circumference and arterial blood pressure were measured. Specific diagnostic methods included an estimation of blood glucose level, triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) in blood serum.

Results. All the subjects (460 persons) were divided into age (18–39 years, 40–59 years, 60 years and older), ethnic (the Shors and the non-Shors) and gender (men and women) groups. Generally, the metabolic syndrome was diagnosed in 40.2% of inhabitants of Mountain Shoria. Metabolic syndrome (MS) was presented in 12.4% of indigenous men and in 47.8% of non-indigenous examined men (р=0.00001). MSwasrevealedin 36.8%, of Shor-women and in 60.7% of non-Shor women (р=0.00002). The most common variant of 3-component MS was abdominal obesity + arterial hypertension + hyperglycemia and the rarest was – abdominal obesity + TG + hyperglycemia. The most common variant of 4-component MS was a combination of abdominal obesity + hyperglycemia + arterial hypertension + HDL-C, the rarest was abdominal obesity + arterial hypertension + TG + HDL-C. Different variants of 3-component and 4-component MS occurred with similar frequency in all age groups of the Shors and non-Shors.

Conclusions. Generally MSoccurred more frequently in non-indigenous inhabitants than in indigenous inhabitants. Only in women of young age group this pathology was revealed with the similar frequency among both ethnic groups. Among all the inhabitants of Mountain Shoria the most frequent clinical variant of 3-component MS was a combination of abdominal obesity + arterial hypertension + hyperglycemia and of 4-component variant – a combination of abdominal obesity + hyperglycemia + arterial hypertension + HDL-C.

Metabolic syndrome, Mountain Shoria, the Shors, obesity.

1. Ротарь О.П., Либис Р.А., Исаева Е.Н., и др. Распространенность метаболического синдрома в разных городах РФ //Российский кардиологический журнал. – 2012. – №. 2. – С. 55-62. [Rotar OP, Libis RA, Isaeva EN, et al. Metabolic syndrome prevalence in Russian cities. Russian Journal of Cardiology. 2012;(2):55-62. (In Russ.)] doi: 10.15829/1560-4071-2012-2-55-62

2. Mottillo S, Filion KB, Genest J, et al. The Metabolic Syndrome and Cardiovascular Risk. J Am Coll Cardiol. 2010;56(14):1113-1132. doi: 10.1016/j.jacc.2010.05.034.

3. Hutcheson R, Rocic P. The Metabolic Syndrome, Oxidative Stress, Environment, and Cardiovascular Disease: The Great Exploration. Experimental Diabetes Research. 2012;2012:1-13. doi: 10.1155/2012/271028.

4. Романова Т.А., Полупанов А.Г., Ческидова Н.Б., Джумагулова А.С. Влияние метаболического синдрома и его компонентов на риск и особенности развития гипертрофии левого желудочка у больных эссенциальной гипертензией. //Наука и новые технологии. – 2010. – № 2. – C. 122-125. [Romanova TA, Polupanov AG, Cheskidova NB, Dzhumagulova AS. Effect of metabolic syndrome and its components on risk and features of the left ventricular hypertrophy in patients with essential hypertension. Nauka, nove tekhnologii i innovatsii. 2010;(2):122-125 (In Russ)]

5. Zidek W, Naditch-Brûlé L, Perlini S, et al. Blood pressure control and components of the metabolic syndrome: the GOOD survey. Cardiovasc Diabetol. 2009;8(1):51. doi: 10.1186/1475-2840-8-51.

6. Hari P, Nerusu K, Veeranna V, et al. A Gender-Stratified Comparative Analysis of Various Definitions of Metabolic Syndrome and Cardiovascular Risk in a Multiethnic U.S. Population. Metab Syndr Relat Disord. 2012;10(1):47-55. doi: 10.1089/met.2011.0087.

7. Небесных А. Л. Особенности проявлений метаболического синдрома в разных этнических группах. //Сибирский медицинский журнал. – 2013. – № 7. – C.19-23. [Nebesnykh AL. The characteristics of metabolic syndrome manifestations in different ethnic groups. Sibirskiy meditsinskiy zhurnal. 2013:(7)19-23 (In Russ)]

8. Никитин Ю.П., Воевода М.И., Симонова Г.И. Сахарный диабет и метаболический синдром в Сибири и на Дальнем Востоке. //Вестник РАМН. – 2012. – Т. 67. – №. 1. – С. 66-74 [Nikitin YP, Voevoda МI, Simonova GI. Diabetes mellitus and metabolic syndrome in Siberia and in the Far East. Vestnik RAMN. 2012;67(1):66-74. (In Russ)]

9. Ханарин Н.В., Килина О.Ю., Иванова С.Н., и др Обоснование персонифицированного подхода к диагностике,профилактике и лечению метаболического синдрома среди жителей Хакасии. Вестник новых медицинских технологий – 2014. – №. 1. – С. 8. [Khanarin NV, Kilina OY, Ivanova SN. Justification of personified approach to diagnostics, prevention and treatment of metabolic syndrome among inhabitants of Khakassia. Vestnik novykh meditsinskikh tekhnologiy. 2014;(1):8. (In Russ)] doi: 10.12737/5949

10. Guerrero-Romero F, Rodr, ıacute M. Concordance between the 2005 International Diabetes Federation definition for diagnosing metabolic syndrome with the National Cholesterol Education Program Adult Treatment Panel III and the World Health Organization definitions. Diabetes Care. 2005;28(10):2588a-2589.

11. Огарков М.Ю., Барбараш О.Л., Казачек Я.В., и др. Рас­про­стра­нен­ность компонентов метаболического синдрома Х у коренного и некоренного населения Горной Шории. //Сибирский Научный Медицинский журнал. – 2004. – № 1. – С.108-111. [Ogarkov MY, Barbarash OL, Kazachek YV, et all. The prevalence of metabolic syndrome X in the indigenous and non-indigenous Mountain Shoria. Sibirskiy Nauchnyy Meditsinskiy zhurnal. 2004;(1):108-111. (In Russ)]

12. Цыганкова Д.П., Мулерова Т.А., Огарков М.Ю., и др. Изменение условий проживания, как фактор, влияющий на распространенность ожирения среди жителей Горной Шории. //Атеросклероз. – 2016. – № 1. – С.40-46. [Tsygankova DP, Mulerova TA, Ogarkov MYu, et al. Changing of living conditions as a factor affecting the prevalence of obesity among the inhabitants of Mountain Shoria. Ateroskleroz. 2016;(1):40-46 (In Russ)]