Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome
https://doi.org/10.14341/omet2015223-29
Abstract
The aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparable
by age, sex ratio and BMI. The first group consisted of 41 patients with obstructive sleep apnea syndrome (OSAS), the second (controls) – 35 patients without breath disorders during sleep. OSAS is accompanied by the increase in urinary cortisol during the night, high levels of
basal insulin, disturbances of hepatic production of IGF-1, dysfunction of the pituitary-gonadal axis. Our results show that sleep-related breathing disorders render markedly and negatively affect on hormonal parameters of patients with obesity. As a reliable difference of basal
secretion of orexin A in obese patients with and without OSAS was not revealed (42,0 [14; 99,5] vs. 18,0 [14,5; 124,5] pg/ml; р=0,9), we were not able to show the existence that the existence of OSAS is followed by any special changes of activity of the orexin system.
About the Authors
Natalya Viktorovna Strueva
Endocrinology Research Centre
Russian Federation
Ph.D student
Russian Federation
Ph.D student
Galina Afanas'evna Melnichenko
Endocrinology Research Centre
Russian Federation
MD, Ph.D. Academician of the Russian Academy of Sciences, Director of the Clinical Endocrinology Institute
Russian Federation
MD, Ph.D. Academician of the Russian Academy of Sciences, Director of the Clinical Endocrinology Institute
Mikhail Gur'evich Poluektov
I. M. Sechenov First Moscow State Medical University
Russian Federation
PhD, Head of the Department of Sleep Medicine in I.M. Sechenov First Moscow State Medical University
Russian Federation
PhD, Head of the Department of Sleep Medicine in I.M. Sechenov First Moscow State Medical University
Larisa Viktorovna Savel'eva
Endocrinology Research Centre
Russian Federation
Phd, Head of the Department of therapy treatment of endocrinopathies
Russian Federation
Phd, Head of the Department of therapy treatment of endocrinopathies
Gulinara Viktorovna Katsya
Endocrinology Research Centre
Sc.D, chief researcher of the Laboratory of Biochemical Endocrinology and hormonal analysis
Sc.D, chief researcher of the Laboratory of Biochemical Endocrinology and hormonal analysis
Nikolay Petrovich Goncharov
Endocrinology Research Centre
Russian Federation
Sc.D., prof ., head of the Laboratory of Biochemical Endocrinology and hormonal analysis
Russian Federation
Sc.D., prof ., head of the Laboratory of Biochemical Endocrinology and hormonal analysis
References
1. Ожирение: этиология, патогенез, клинические аспекты. / Под ред. Дедова И.И., Мельниченко Г.А. – М.: ООО «Медицинское информационное агентство»; 2006. [Ozhirenie: etiologiya, patogenez, klinicheskie aspekty. Ed. By Dedov II, Mel'nichenko GA. Moscow: Meditsinskoe informatsionnoe agentstvo; 2006. (In Russ).]
2. Полуэктов М.Г. Эндокринная система и нарушения сна. / В кн. Сомнология и медицина сна; под ред. Левина Я.И., Полуэктова М.Г. – М.: Медфорум; 2013. – C. 408–422. [Poluektov MG. Endokrinnaya sistema i narusheniya sna. In: Levin YaI, Poluektov MG editors. Somnologiya i meditsina sna. Moscow. Medforum; 2013. p. 408–422. (In Russ).]
3. Kim NH. Obstructive Sleep Apnea and Abnormal Glucose Metabolism. Diabetes & Metabolism Journal. 2012;36(4):268. doi: 10.4093/dmj.2012.36.4.268.
4. Basoglu O, Sarac F, Sarac S, Uluer H, Yilmaz C. Metabolic syndrome, insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein in obese patients with obstructive sleep apnea syndrome. Annals of Thoracic Medicine. 2011;6(3):120. doi: 10.4103/1817-1737.82440
5. Mortimore IL, Marshall I, Wraith PK, Sellar RJ, Douglas NJ. Neck and Total Body Fat Deposition in Nonobese and Obese Patients with Sleep Apnea Compared with That in Control Subjects. American Journal of Respiratory and Critical Care Medicine. 1998;157(1):280–3. doi: 10.1164/ajrccm.157.1.9703018.
6. Pillar G, Shehadeh N. Abdominal Fat and Sleep Apnea: The chicken or the egg? Diabetes Care. 2008;31(Supplement 2):S303–S9. doi: 10.2337/dc08-s272.
7. Ursavas A, Karadag M, Ilcol YO, Ercan I, Burgazlioglu B, Coskun F, et al. Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome. Lung. 2007;185(5):309–14. doi: 10.1007/s00408-007-9026-x.
8. Lanfranco F, Motta G, Minetto MA, Baldi M, Balbo M, Ghigo E, et al. Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome. International Journal of Endocrinology. 2010;2010:1–11. doi: 10.1155/2010/474518.
9. Busquets X, Barb, eacute, Ferran, Barcel, oacute, et al. Decreased Plasma Levels of Orexin-A in Sleep Apnea. Respiration. 2004;71(6):575–9. doi: 10.1159/000081757.
10. Luboshitzky R, Lavie L, Shen-Orr Z, Herer P. Altered Luteinizing Hormone and Testosterone Secretion in Middle-Aged Obese Men with Obstructive Sleep Apnea. Obesity Research. 2005;13(4):780–6. doi: 10.1038/oby.2005.88.
11. Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, et al. Decreased Pituitary-Gonadal Secretion in Men with Obstructive Sleep Apnea. The Journal of Clinical Endocrinology & Metabolism. 2002;87(7):3394–8. doi: 10.1210/jcem.87.7.8663.
12. Sánchez-de-la-Torre M, Mediano O, Barceló A, Piérola J, de la Peña M, Esquinas C, et al. The influence of obesity and obstructive sleep apnea on metabolic hormones. Sleep and Breathing. 2011;16(3):649–56. doi: 10.1007/s11325-011-0552-7.
13. Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M. Influence of treatment on leptin levels in patients with obstructive sleep apnoea. European Respiratory Journal. 2004;23(4):601–4. doi: 10.1183/09031936.04.00067804.
14. Tomfohr LM, Edwards KM, Dimsdale JE. Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Medicine Reviews. 2012;16(3):243–9. doi: 10.1016/j.smrv.2011.05.003.
15. Adam JA, Menheere PPCA, van Dielen FMH, Soeters PB, Buurman WA, Greve JWM. Decreased plasma orexin-A levels in obese individuals. International Journal of Obesity. 2002;26(2):274–6. doi: 10.1038/sj.ijo.0801868.
16. Teske JA, Billington CJ, Kotz CM. Hypocretin/orexin and energy expenditure. Acta Physiologica. 2010;198(3):303–12. doi: 10.1111/j.1748-1716.2010.02075.x.
17. International classification of sleep disorders, 2nd ed.: Diagnostic and coding manual. Westchester, Ill.: American Academy of Sleep Medicine 2005, 298 pages.
18. Fan JF, Fan WW, Gu YH, Zhang YK, Huang WG, Hou Y, et al. [The relationship between abdominal fat volume and obstructive sleep apnea hypopnea syndrome in obesity people]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2013;29(1):37–9. PMID:23600129
19. Vgontzas AN, Pejovic S, Zoumakis E, Lin HM, Bentley CM, Bixler EO, et al. Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy. The Journal of Clinical Endocrinology & Metabolism. 2007;92(11):4199–207. doi: 10.1210/jc.2007-0774.
20. Arnardottir ES, Maislin G, Jackson N, Schwab RJ, Benediktsdottir B, Teff K, et al. The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study. International Journal of Obesity. 2012;37(6):835–42. doi: 10.1038/ijo.2012.138.
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For citations:
Strueva N.V., Melnichenko G.A., Poluektov M.G., Savel'eva L.V., Katsya G.V., Goncharov N.P. Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome. Obesity and metabolism. 2015;12(2):24-30. (In Russ.) https://doi.org/10.14341/omet2015223-29
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