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Ожирение и метаболизм

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Витамин К-зависимые белки: остеокальцин, матриксный Gla-белок и их внекостные эффекты

https://doi.org/10.14341/2071-8713-4818

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Аннотация

Витамин К - это жирорастворимый витамин, который играет значимую роль в обмене веществ в костях и в соединительной ткани, поддержании свертывающих свойств крови. Витамин K участвует в карбоксилировании остатков глутаминовой кислоты в полипептидных цепях 14 человеческих белков, что обеспечивает их необходимыми функциональными свойствами. Недостаточное витамин К-зависимое карбоксилирование данных белков, приводит к изменению их биологической активности. В данном обзоре литературы широко освещаются механизмы витамин К-зависимого карбоксилирования, механизм костного и внекостного действия различных по степени карбоксилирования форм остеокальцина и матриксного Gla-белка.

Об авторах

Ю. В. Панкратова

Россия

ординатор



Екатерина Александровна Пигарова

Россия

к.м.н., старший научный сотрудник отделения нейроэндокринологии и остеопатий



Лариса Константиновна Дзеранова

Россия

д.м.н., главный научный сотрудник отделения нейроэндокринологии и остеопатий



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Для цитирования:


Панкратова Ю.В., Пигарова Е.А., Дзеранова Л.К. Витамин К-зависимые белки: остеокальцин, матриксный Gla-белок и их внекостные эффекты. Ожирение и метаболизм. 2013;10(2):11-18. https://doi.org/10.14341/2071-8713-4818

For citation:


Pankratova Yu.В., Pigarova E.A., Dzeranova L.K. Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects. Obesity and metabolism. 2013;10(2):11-18. (In Russ.) https://doi.org/10.14341/2071-8713-4818

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ISSN 2071-8713 (Print)
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