ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-4818ometendo-4818Research ArticleСтатьиArticlesВитамин К-зависимые белки: остеокальцин, матриксный Gla-белок и их внекостные эффектыVitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effectsПанкратоваЮ. В.PankratovaYu В

ординатор

ordinator

pankratov.po@yandex.ruПигароваЕкатерина АлександровнаPigarovaE A

к.м.н., старший научный сотрудник отделения нейроэндокринологии и остеопатий

k.m.n., starshiy nauchnyy sotrudnik otdeleniya neyroendokrinologii i osteopatiy

kpigarova@gmail.comДзерановаЛариса КонстантиновнаDzeranovaL K

д.м.н., главный научный сотрудник отделения нейроэндокринологии и остеопатий

d.m.n., glavnyy nauchnyy sotrudnik otdeleniya neyroendokrinologii i osteopatiy

dzeranovalk@yandex.ru201315062013102№2 (2013)1118Copyright © Панкратова Ю.В., Пигарова Е.А., Дзеранова Л.К., 20132013Панкратова Ю.В., Пигарова Е.А., Дзеранова Л.К.Pankratova Y.В., Pigarova E.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/4818

Витамин К - это жирорастворимый витамин, который играет значимую роль в обмене веществ в костях и в соединительной ткани, поддержании свертывающих свойств крови. Витамин K участвует в карбоксилировании остатков глутаминовой кислоты в полипептидных цепях 14 человеческих белков, что обеспечивает их необходимыми функциональными свойствами. Недостаточное витамин К-зависимое карбоксилирование данных белков, приводит к изменению их биологической активности. В данном обзоре литературы широко освещаются механизмы витамин К-зависимого карбоксилирования, механизм костного и внекостного действия различных по степени карбоксилирования форм остеокальцина и матриксного Gla-белка.

Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation.

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The authors declare that there are no conflicts of interest present.