Telomere length and features of metabolic syndrome development: a systematic review

Metabolic syndrome is a common pathophysiological complex of metabolic disorder, which is characterized by a central type of obesity, arterial hypertension, hyperglycemia, hyperinsulinemia, decreased sensitivity of peripheral tissues to insulin. This symptom complex is also associated with atherogenic dyslipidemia, which is characterized by increased triglyceride levels, decreased high-density lipoprotein (HDL) levels, and increased cholesterol levels. It should be noted that metabolic syndrome has become one of the main public health problems around the world and attracts the interesting of researchers in this area. There are a large number of directions for studying this pathophysiological complex, one of which is the dependence of metabolic syndrome development on the length of chromosome telomeres. Analysis of scientific literature over the past 6 years showed that most authors agree that there is a positive correlation between the development of metabolic syndrome and its components, including oxidative stress as a key pathogenic factor, and changes in the length of chromosome telomeres, suggesting that this parameter could be used as a potential biomarker for the development of metabolic syndrome.

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