ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13248ometendo-13248Research ArticleОБЗОРЫREVIEWSДлина теломер и особенности развития метаболического синдрома: систематический обзорTelomere length and features of metabolic syndrome development: a systematic reviewhttps://orcid.org/0009-0002-3307-907XЗауроваМ. Б.ZaurovaM. B.

Заурова Мариамь Борисовна  

Крым, Симферополь, 295051, бульвар Ленина, 5/7

Mariam B. Zaurova

5/7 Lenin Boulevard, 295051, Simferopol, Crimea

zaurova.mariam@bk.ruhttps://orcid.org/0009-0002-3127-9465НечитайлоА. А.NechitailoA. A.

Нечитайло Алена Андреевна

Симферополь

Alena A. Nechitailo

Simferopol

nechitailo.aliona@yandex.ruhttps://orcid.org/0000-0003-3065-5748ФомочкинаИ. И.FomochkinaI. I.

Фомочкина Ирина Ивановна , д.м.н., профессор

ResearcherID: AAC-7912-2022; Scopus Author ID: 24449143700

Симферополь

Irina I. Fomochkina, MD, professor

ResearcherID: AAC-7912-2022; Scopus Author ID: 24449143700

Simferopol

fomochkina_i@mail.ruhttps://orcid.org/0000-0002-9448-6034ШевандоваА. А.ShevandovaA. A.

Шевандова Алина Алексеевна

ResearcherID: ABA-5691-2020; Scopus Author ID: 57218800193

Симферополь

Alina A. Shevandova

ResearcherID: ABA-5691-2020; Scopus Author ID: 57218800193

Simferopol

Shevandova_A_A@mail.ruhttps://orcid.org/0009-0000-3231-6091КоврижныхЕ. В.KovrizhnykhE. V.

Коврижных Екатерина Викторовна

Симферополь

Ekaterina V. Kovrizhnykh 

Simferopol

medkkovr@mail.ruhttps://orcid.org/0000-0002-1309-4005КубышкинА. В.KubyshkinA. V.

Кубышкин Анатолий Владимирович , д.м.н., профессор

Researcher ID: AAU-1822-2020; Scopus Author ID: 7004172980

Симферополь

Anatoliy V. Kubyshkin, MD, Professor 

Researcher ID: AAU-1822-2020; Scopus Author ID: 7004172980 

Simferopol

kubyshkin_av@mail.ruОрдена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского, ФГАОУ ВО «КФУ им. В.И. Вернадского»РоссияOrders of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, "V.I. Vernadsky Crimean Federal University"Russian Federation20261807202623296105Copyright © Заурова М.Б., Нечитайло А.А., Фомочкина И.И., Шевандова А.А., Коврижных Е.В., Кубышкин А.В., 20262026Заурова М.Б., Нечитайло А.А., Фомочкина И.И., Шевандова А.А., Коврижных Е.В., Кубышкин А.В.Zaurova M.B., Nechitailo A.A., Fomochkina I.I., Shevandova A.A., Kovrizhnykh E.V., Kubyshkin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13248

Метаболический синдром является распространенным патофизиологическим комплексом нарушений обмена веществ, который характеризуется центральным типом ожирения, артериальной гипертензией, гипергликемией, гиперинсулинемией, снижением чувствительности периферических тканей к инсулину. Данный симптомокомплекс также представлен атерогенной дислипидемией, проявляющейся увеличением содержания триглицеридов, снижением уровня липопротеинов высокой плотности (ЛПВП) и холестерина. В настоящее время метаболический синдром приобрел статус одной из основных проблем общественного здравоохранения всего мира, за счет чего привлекает внимание большого количества исследователей. Существует множество направлений изучения данного патофизиологического комплекса, одним из которых является анализ зависимости между формированием метаболического синдрома и генетическими маркерами клеточного старения, в частности длиной теломер хромосом. В ходе систематического анализа отечественной и зарубежной литературы, опубликованной в течение последних 6 лет, было установлено, что большинство авторов склоняются к наличию положительной связи между формированием метаболического синдрома и его отдельных компонентов, в том числе окислительного стресса как ключевого патогенетического звена и изменением длины теломер хромосом, что позволяет рассматривать данный параметр в качестве потенциального биомаркера формирования метаболического синдрома.

Metabolic syndrome is a common pathophysiological complex of metabolic disorder, which is characterized by a central type of obesity, arterial hypertension, hyperglycemia, hyperinsulinemia, decreased sensitivity of peripheral tissues to insulin. This symptom complex is also associated with atherogenic dyslipidemia, which is characterized by increased triglyceride levels, decreased high-density lipoprotein (HDL) levels, and increased cholesterol levels. It should be noted that metabolic syndrome has become one of the main public health problems around the world and attracts the interesting of researchers in this area. There are a large number of directions for studying this pathophysiological complex, one of which is the dependence of metabolic syndrome development on the length of chromosome telomeres. Analysis of scientific literature over the past 6 years showed that most authors agree that there is a positive correlation between the development of metabolic syndrome and its components, including oxidative stress as a key pathogenic factor, and changes in the length of chromosome telomeres, suggesting that this parameter could be used as a potential biomarker for the development of metabolic syndrome.

метаболический синдромтеломерытеломеразаинсулинорезистентностьдиабетокислительный стрессожирениеmetabolic syndrometelomerestelomeraseinsulin resistancediabetesoxidative stressobesityИсследование выполнено при финансовой поддержке ФГАОУ ВО «КФУ им. В.И. Вернадского» в рамках проекта МОЛ/2024/4.ReferencesУспенский Ю.П., Петренко Ю.В., Гулунов З.Х., и др. Метаболический синдром. Учебное пособие – СПб; 2017.Uspenskij YuP, Petrenko YuV, Gulunov ZH, et al. Metabolic Syndrome: A Study Guide. St. Petersburg; 2017. (In Russ.)Зорина В.В., Мельникова Е.С., Иванова А.А. и др. Ассоциация полиморфизмов rs9939609 гена FTO, rs7903146 гена tCF7L2, rs1799883 гена FABP2 с морбидным ожирением у женщин. // Медицинская генетика. — 2022. — Т.21. — №7. — С. 52-55. doi: https://doi.org/10.25557/2073-7998.2022.07.52-55Zorina VV, Melnikova ES, Ivanova AA, et al. Association of FTO rs9939609, TCF7L2 rs7903146, FABP2 rs1799883 polymorphisms with morbid obesity in women. Medical Genetics. 2022;21(7):52-55. (In Russ.) doi: https://doi.org/10.25557/2073-7998.2022.07.52-55Wang HH, Lee DK, Liu M, et al. Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome. Pediatr Gastroenterol Hepatol Nutr. 2020;23(3):189-230. doi: https://doi.org/10.5223/pghn.2020.23.3.189Wang HH, Lee DK, Liu M, et al. Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome. Pediatr Gastroenterol Hepatol Nutr. 2020;23(3):189-230. doi: https://doi.org/10.5223/pghn.2020.23.3.189Loh NY, Rosoff D, Noordam R, et al. Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study. Obesity (Silver Spring). 2023;31(8):2189-2198. doi: https://doi.org/10.1002/oby.23810Loh NY, Rosoff D, Noordam R, et al. Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study. Obesity (Silver Spring). 2023;31(8):2189-2198. doi: https://doi.org/10.1002/oby.23810Anifandis G, Samara M, Simopoulou M, et al. Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF. J Dev Biol. 2021; 9(4):49. doi: https://doi.org/10.3390/jdb9040049Anifandis G, Samara M, Simopoulou M, et al. Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF. J Dev Biol. 2021; 9(4):49. doi: https://doi.org/10.3390/jdb9040049Di Micco R, Krizhanovsky V, Baker D, et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Revi Mol Cell Biol. 2021;22(2):75-95. doi: https://doi.org/10.1038/s41580-020-00314-wDi Micco R, Krizhanovsky V, Baker D, et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Revi Mol Cell Biol. 2021;22(2):75-95. doi: https://doi.org/10.1038/s41580-020-00314-wTurner KJ, Vasu V, Griffin DK. Telomere biology and human phenotype. Cells. 2019; 8(1):73. doi: https://doi.org/10.3390/cells8010073Turner KJ, Vasu V, Griffin DK. Telomere biology and human phenotype. Cells. 2019; 8(1):73. doi: https://doi.org/10.3390/cells8010073Lin J, Epel E. Stress and telomere shortening: Insights from cellular mechanisms. Ageing Res Rev. 2022;73:101507. doi: https://doi.org/10.1016/j.arr.2021.101507Lin J, Epel E. Stress and telomere shortening: Insights from cellular mechanisms. Ageing Res Rev. 2022;73:101507. doi: https://doi.org/10.1016/j.arr.2021.101507Wang Q, Zhan Y, Pedersen NL et al. Telomere length and allcause mortality: a meta-analysis. Ageing Res Rev. 2018;48:11–20. doi: https://doi.org/10.1016/j.arr.2018.09.002Wang Q, Zhan Y, Pedersen NL et al. Telomere length and allcause mortality: a meta-analysis. Ageing Res Rev. 2018;48:11–20. doi: https://doi.org/10.1016/j.arr.2018.09.002Gorenjak V, Petrelis AM, Stathopoulou MG, et al. Telomere length determinants in childhood. Clin Chem Lab Med. 2020;58(2):162–177. doi: https://doi.org/10.1515/cclm-2019-0235Gorenjak V, Petrelis AM, Stathopoulou MG, et al. Telomere length determinants in childhood. Clin Chem Lab Med. 2020;58(2):162–177. doi: https://doi.org/10.1515/cclm-2019-0235Акопян А.А., Кириллова К.И., Стражеско И.Д. и др. Связь полиморфизма генов TNF, MMP9, CYBA с субклиническими изменениями артериальной стенки и факторами риска сердечно сосудистых заболеваний // Гены и клетки. — 2020. — Т.15. — №2. — С. 81-88. doi: https://doi.org/10.23868/202004020Akopyan AA, Kirillova KI, Strazhesko ID, et al. Association of TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes and cardiovascular diseases risk factors. Genes & Cells. 2020;15(2): 81-88. (In Russ.) doi: https://doi.org/10.23868/202004020Lansdorp PM. Telomeres, aging, and cancer: the big picture. Blood. 2022; 139(6): 813–821. doi: https://doi.org/10.1182/blood.2021014299Lansdorp PM. Telomeres, aging, and cancer: the big picture. Blood. 2022; 139(6): 813–821. doi: https://doi.org/10.1182/blood.2021014299Jafri MA, Ansari SA, Alqahtani MH, et al. Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Med. 2016; 8(1): 69. doi: https://doi.org/10.1186/s13073-016-0324-xJafri MA, Ansari SA, Alqahtani MH, et al. Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Med. 2016; 8(1): 69. doi: https://doi.org/10.1186/s13073-016-0324-xТронько Н.Д., Черская М.С., Кухарский В.М., и др. Высокая активность теломеразы, парасимпатики и супероксиддисмутазы — причина укорочения теломер у пациентов с церебральным атеросклерозом и сахарным диабетом. // The Scientific Heritage. — 2020. — №50. — С. 63-70.Tronko N, Cherska M, Kukharskyy V, et al. High activity of telomerase, parasympathetic and superoxide dismutase – the cause of telomere shortening in patients with cerebral atherosclerosis and diabetes millitus. The Scientific Heritage. 2020; (50): 63- 70. (In Russ.)Wan F, Ding Y, Zhang Y, et al. Zipper head mechanism of telomere synthesis by human telomerase. Cell research. 2021; 31(12): 1275-1290. doi: https://doi.org/10.1038/s41422-021-00586-7Wan F, Ding Y, Zhang Y, et al. Zipper head mechanism of telomere synthesis by human telomerase. Cell research. 2021; 31(12): 1275-1290. doi: https://doi.org/10.1038/s41422-021-00586-7Armanios M. The role of telomeres in human disease. Annual Rev Genomics Human Genet. 2022;23: 363-381. doi: https://doi.org/10.1146/annurev-genom-010422-091101Armanios M. The role of telomeres in human disease. Annual Rev Genomics Human Genet. 2022;23: 363-381. doi: https://doi.org/10.1146/annurev-genom-010422-091101Plyasova AA; Zhdanov DD. Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes. Biomedicines. 2021; 9(5): 526. doi: https://doi.org/10.3390/biomedicines9050526Plyasova AA; Zhdanov DD. Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes. Biomedicines. 2021; 9(5): 526. doi: https://doi.org/10.3390/biomedicines9050526Хавинсон В.Х., Кузник Б.И., Рыжак Г.А., и др. Ирисин, бетатрофин, сахарный диабет, ожирение и метаболический синдром. Эпигенетические механизмы регуляции //Успехи физиологических наук. — 2018. — Т.49. — №1. — С. 72-86.Khavison VKh, Kuznik BI, Ryzhak GA, et al. Irisin, Betatrophin, Diabetes, Obesity and Metabolic Syndrome. Epigenetic Regulatory Mechanisms. Uspekhi fiziologicheskih nauk = Advances in physiological sciences. 2022; 21(7): 52-55. (In Russ.)Радугин Ф. М., Тимкина Н. В., Каронова Т. Л. Метаболические свойства ирисина в норме и при сахарном диабете // Ожирение и метаболизм. — 2022. — Т. 19. — №. 3. — С. 332-339. doi: https://doi.org/10.14341/omet12899Radugin FM, Timkina NV, Karonova TL. Metabolic properties of irisin in health and in diabetes mellitus. Obesity and metabolism. 2022; 19(3): 332-339. (In Russ.) doi: https://doi.org/10.14341/omet12899Higuchi Y, Maeda T, Guan JZ, et al. Diagonal earlobe crease are associated with shorter telomere in male Japanese patients with metabolic syndrome. Circ J. 2009;73(2):274-279. doi: https://doi.org/10.1253/circj-cj-08-0267Higuchi Y, Maeda T, Guan JZ, et al. Diagonal earlobe crease are associated with shorter telomere in male Japanese patients with metabolic syndrome. Circ J. 2009;73(2):274-279. doi: https://doi.org/10.1253/circj-cj-08-0267Tucker LA. Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation. Biomed Res Int. 2022;2022:2146596. doi: https://doi.org/10.1155/2022/2146596.Tucker LA. Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation. Biomed Res Int. 2022;2022:2146596. doi: https://doi.org/10.1155/2022/2146596.Плотников Д.Ю. Менделевская рандомизация: применение генетической информации в эпидемиологических исследованиях (обзор) // Научные результаты биомедицинских исследований. — 2023. — Т.9. — №2. — С. 158-172. doi: https://doi.org/10.18413/2658-6533-2023-9-2-0-1Plotnikov DY. Mendelian randomization: using genetic information in epidemiological studies (review). Research Results in Biomedicine. 2023; 9(2): 158- 172. (In Russ.) doi: https://doi.org/10.18413/2658-6533-2023-9-2-0-1Дудинская Е.Н., Ткачева О.Н., Браилова Н.В., и др. Биология теломер и метаболические нарушения: роль инсулинорезистентности и сахарного диабета 2 типа. // Проблемы Эндокринологии. — 2020. — Т.66. — №4. — С. 35-44. doi: https://doi.org/10.14341/probl12510Dudinskaya EN, Tkacheva ON, Brailova NV, et al. Telomere biology and metabolic disorders: the role of insulin resistance and type 2 diabetes. Problems of Endocrinology. 2020;66(4):35-44. (In Russ.) doi: https://doi.org/10.14341/probl12510Yuan X, Yang Q, Yao Y, et al. Role of HOMA-IR and IL-6 as screening markers for the metabolic syndrome in patients with chronic schizophrenia: a psychiatric hospital-based cross-sectional study. European Archives of Psychiatry and Clinical Neuroscience. 2024;274(5):1063-1070. doi: https://doi.org/10.1007/s00406-023-01618-6Yuan X, Yang Q, Yao Y, et al. Role of HOMA-IR and IL-6 as screening markers for the metabolic syndrome in patients with chronic schizophrenia: a psychiatric hospital-based cross-sectional study. European Archives of Psychiatry and Clinical Neuroscience. 2024;274(5):1063-1070. doi: https://doi.org/10.1007/s00406-023-01618-6Wang X, Cheng Z. Cross-Sectional Studies: Strengths, Weaknesses, and Recommendations. Chest. 2020;158(1S):S65-S71. doi: https://doi.org/10.1016/j.chest.2020.03.012Wang X, Cheng Z. Cross-Sectional Studies: Strengths, Weaknesses, and Recommendations. Chest. 2020;158(1S):S65-S71. doi: https://doi.org/10.1016/j.chest.2020.03.012McAninch D, Bianco-Miotto T, Gatford KL, et al. The metabolic syndrome in pregnancy and its association with child telomere length. Diabetologia. 2020;63(10):2140–2149. doi: https://doi.org/10.1007/s00125-020-05242-0McAninch D, Bianco-Miotto T, Gatford KL, et al. The metabolic syndrome in pregnancy and its association with child telomere length. Diabetologia. 2020;63(10):2140–2149. doi: https://doi.org/10.1007/s00125-020-05242-0Loh NY, Noordam R, Christodoulides C. Telomere length and metabolic syndrome traits: A Mendelian randomisation study. Aging Cell. 2021; 20(8): e13445. doi: https://doi.org/10.1111/acel.13445Loh NY, Noordam R, Christodoulides C. Telomere length and metabolic syndrome traits: A Mendelian randomisation study. Aging Cell. 2021; 20(8): e13445. doi: https://doi.org/10.1111/acel.13445Liu B, Song L, Zhang L, et al. Prenatal secondhand smoke exposure and newborn telomere length. Pediatric Research. 2020;87(6):1081-1085. doi: https://doi.org/10.1038/s41390-019-0594-2Liu B, Song L, Zhang L, et al. Prenatal secondhand smoke exposure and newborn telomere length. Pediatric Research. 2020;87(6):1081-1085. doi: https://doi.org/10.1038/s41390-019-0594-2Lulkiewicz M, Bajsert J, Kopczynski P, et al. Telomere length: how the length makes a difference. Molecular Biology Reports. 2020;47(9):7181-7188. doi: https://doi.org/10.1007/s11033-020-05551-yLulkiewicz M, Bajsert J, Kopczynski P, et al. Telomere length: how the length makes a difference. Molecular Biology Reports. 2020;47(9):7181-7188. doi: https://doi.org/10.1007/s11033-020-05551-yHoffman DJ, Powell TL, Barrett ES, et al. Developmental origins of metabolic diseases. Physiological reviews. 2021;101(3):739-795. doi: https://doi.org/10.1152/physrev.00002.2020Hoffman DJ, Powell TL, Barrett ES, et al. Developmental origins of metabolic diseases. Physiological reviews. 2021;101(3):739-795. doi: https://doi.org/10.1152/physrev.00002.2020Cheng F, Carroll L, Joglekar MV, et al. Diabetes, metabolic disease, and telomere length. Lancet Diabetes Endocrinol. 2021; 9(2): 117-126. doi: https://doi.org/10.1016/S2213-8587(20)30365-XCheng F, Carroll L, Joglekar MV, et al. Diabetes, metabolic disease, and telomere length. Lancet Diabetes Endocrinol. 2021; 9(2): 117-126. doi: https://doi.org/10.1016/S2213-8587(20)30365-XGavia-García G, Rosado-Pérez J, Arista-Ugalde T L, et al. Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging. Biology. 2021;10(4):253. doi: https://doi.org/10.3390/biology10040253Gavia-García G, Rosado-Pérez J, Arista-Ugalde T L, et al. Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging. Biology. 2021;10(4):253. doi: https://doi.org/10.3390/biology10040253Peng X, Huang J, Xia S, et al. Association of leukocyte telomere length with metabolic syndrome in type 2 diabetes mellitus. J Res Med Sci. 2021; 26: 43. doi: https://doi.org/10.4103/jrms.JRMS_793_20.Peng X, Huang J, Xia S, et al. Association of leukocyte telomere length with metabolic syndrome in type 2 diabetes mellitus. J Res Med Sci. 2021; 26: 43. doi: https://doi.org/10.4103/jrms.JRMS_793_20.Chen B, Yan Y, Wang H, Xu J. Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies. Aging Cell. 2023;22(7):e13874. doi: https://doi.org/10.1111/acel.13874.Chen B, Yan Y, Wang H, Xu J. Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies. Aging Cell. 2023;22(7):e13874. doi: https://doi.org/10.1111/acel.13874.Соболева О.А., Торгунакова А.В. Окислительный стресс и длина теломер хромосом человека // Тенденции развития науки и образования. — 2023. — № 97. — С. 145-147. doi: https://doi.org/10.18411/trnio-05-2023-511.Soboleva OA, Torgunakova AV Oxidative stress and telomere length of human chromosomes. Tendencii razvitiya nauki i obrazovaniya = Trends in the development of science and education. 2023; (97): 145-147. (In Russ.) doi: https://doi.org/10.18411/trnio-05-2023-511.Кузник Б.И., Линькова Н.С., Ивко О.М. Оксидативный стресс, старение и короткие пептиды // Успехи физиологических наук. — 2021. — Т.52. — № 2. — С. 13-20. doi: https://doi.org/10.31857/S0301179821020041Kuznik BI, Linkova NS, Ivko OM. Oxidative Stress, Aging and Short Peptidees. Uspekhi fiziologicheskih nauk = Advances in physiological sciences. 2021;52(2):13-20. (In Russ.) doi: https://doi.org/10.31857/S0301179821020041Останина Ю.О., Яхонтов Д.А., Звонкова А.В., и др. Системное воспаление у больных артериальной гипертонией и ишемической болезнью сердца различных возрастных групп. // Сибирский журнал клинической и экспериментальной медицины. — 2019. — Т.34. — №3. — С. 97- 102. doi: https://doi.org/10.29001/2073-8552-2019-34-3-97-102Ostanina YuO, Yakhontov DA, Zvonkova AV, et al. Systemic inflammation in patients with hypertension and coronary artery disease in different age groups. Siberian Journal of Clinical and Experimental Medicine. 2019;34(3):97-102. (In Russ.) doi: https://doi.org/10.29001/2073-8552-2019-34-3-97-102Grunnet LG, Pilgaard K, Alibegovic A, et al. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight. Sci Rep. 2019;9(1):7639. doi: https://doi.org/10.1038/s41598-019-43387-0Grunnet LG, Pilgaard K, Alibegovic A, et al. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight. Sci Rep. 2019;9(1):7639. doi: https://doi.org/10.1038/s41598-019-43387-0Monserrat-Mesquida M, Quetglas-Llabrés M, Capó X, et al. Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State. Antioxidants. 2020; 9(3): 236. doi: https://doi.org/10.3390/antiox9030236Monserrat-Mesquida M, Quetglas-Llabrés M, Capó X, et al. Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State. Antioxidants. 2020; 9(3): 236. doi: https://doi.org/10.3390/antiox9030236Masenga SK, Kabwe LS, Chakulya M, et al. Mechanisms of Oxidative Stress in Metabolic Syndrome. Int. J. Mol. Sci. 2023; 24(9): 7898. doi: https://doi.org/10.3390/ijms24097898Masenga SK, Kabwe LS, Chakulya M, et al. Mechanisms of Oxidative Stress in Metabolic Syndrome. Int. J. Mol. Sci. 2023; 24(9): 7898. doi: https://doi.org/10.3390/ijms24097898Čolak E, Pap D. The role of oxidative stress in the development of obesity and obesity-related metabolic disorders. Journal of Medical Biochemistry. 2021;40(1):1-9. doi: https://doi.org/10.5937/jomb0-24652Čolak E, Pap D. The role of oxidative stress in the development of obesity and obesity-related metabolic disorders. Journal of Medical Biochemistry. 2021;40(1):1-9. doi: https://doi.org/10.5937/jomb0-24652Devrajani T, Abid S, Shaikh H, et al. Relationship between aging and control of metabolic syndrome with telomere shortening: a cross-sectional study. Sci Rep. 2023;13(1):17878. doi: https://doi.org/10.1038/s41598-023-44715-1Devrajani T, Abid S, Shaikh H, et al. Relationship between aging and control of metabolic syndrome with telomere shortening: a cross-sectional study. Sci Rep. 2023;13(1):17878. doi: https://doi.org/10.1038/s41598-023-44715-1Reljic D, Frenk F, Herrmann HJ, et al. Effects of very low volume high intensity versus moderate intensity interval training in obese metabolic syndrome patients: a randomized controlled study. Sci Rep. 2021; 11(1): 2836. doi: https://doi.org/10.1038/s41598-021-82372-4Reljic D, Frenk F, Herrmann HJ, et al. Effects of very low volume high intensity versus moderate intensity interval training in obese metabolic syndrome patients: a randomized controlled study. Sci Rep. 2021; 11(1): 2836. doi: https://doi.org/10.1038/s41598-021-82372-4

The authors declare that there are no conflicts of interest present.