Preview

Obesity and metabolism

Advanced search

Effectiveness and safety of varying intensity physical training in obese patients

https://doi.org/10.14341/omet13156

Abstract

AIM. To evaluate the effectiveness and safety of physical training of varying intensity in obese patients.

METHODS. A single-center open-label randomized trial of 37 obese patients. The patients were divided into three groups: group 1 — 15 patients 5–7 days a week for 60 minutes performed training walking at a speed reached at the level of 25–30% VO2peak, group 2 — 15 patients 5-7 days a week for 40 minutes performed training walking at a speed reached at the level of 60% VO2peak, group 3 — 7 Patients were trained to walk 3 times a week for 30 minutes at a speed reached at the level of 75-80% VO2peak. The dynamics of BMI, OT, and TFN were analyzed (based on the assessment of oxygen uptake at the peak of PH (VO2peak)).

RESULTS. The inclusion of patients in group 3 was prematurely discontinued due to poor tolerance of high-intensity interval training, therefore, a total of 7 patients were included in group 3. After 6 months of training, the most pronounced decrease in BMI and OT, as well as a greater increase in TFN, walking speed at the lactate threshold and the period of predominant fat absorption during physical training were recorded in group 1, whose patients trained at an intensity of 25–30% of VO2peak. According to the results of the analysis of the observation diaries, a high frequency of adverse events was revealed in the group of patients performing moderate and high intensity training.

CONCLUSIONS. 1. FT with an intensity of 75–80% VO2peak not well tolerated by obese patients and is less effective compared to FT with an intensity of 25–30% and 60% of VO2peak. 2. Aerobic workouts with an intensity of 25–30% VO2peak are the safest and most effective in obese patients.

About the Authors

T. A. Lelyavina
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Tatiana A. Lelyavina, MD, PhD

Researcher ID: ABH-3082-2020

Scopus Author ID: 56700273900

2 Akkuratova street, 197341 St-Petersburg


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



A. Y. Babenko
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Alina U, Babenko, MD, PhD, Professor

Researcher ID (WoS): Q-6714-2016D-3729-2014

Scopus Author ID: 33767446300

 


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



D. L. Sonin
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Dmitriy L. Sonon, MD, PhD

Researcher ID: A-1948-2014

Scopus Author ID: 10641700000


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



N. O. Markina
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Natalya O. Markina, PhD

Researcher ID: OGO-1630-2025

Scopus ID: 59238816000


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



K. A. Stein
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Kseniya A. Shtein, PhD

Researcher ID: OUI-0235-2025

Scopus Author ID: 60096497100


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



E. V. Shlyakhto
Federal State Budgetary Institution «V.A. Almazov National Medical Research Center» of the Ministry of Health of the Russian Federation
Russian Federation

Eugeny V. Shlyakhto, MD, PhD, Academician

Researcher ID: A-6939-2014

Scopus Author ID: 16317213100


Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



References

1. Gaskin CJ, Cooper K, Stephens LD, Peeters A, Salmon J, Porter J. Clinical practice guidelines for the management of overweight and obesity published internationally: A scoping review. Obes Rev. 2024;25(5):e13700. doi: https://doi.org/10.1111/obr.13700

2. Nutrition and Metabolic Management Branch of China International Exchange and Promotive Association for Medical and Health Care, Clinical Nutrition Branch of Chinese Nutrition Society, Chinese Diabetes Society, Chinese Society for Parenteral and Enteral Nutrition, Chinese Clinical Nutritionist Center of Chinese Medical Doctor Assocition. Guidelines for medical nutrition treatment of overweight/ obesity in China (2021). Asia Pac J Clin Nutr. 2022;31(3):450-482. doi: https://doi.org/10.6133/apjcn.202209_31(3).0013

3. Dedov II, Shestakova MV, Melnichenko GA, et al. Interdisciplinary clinical practice guidelines «Management of obesity and its comorbidities». Obesity and metabolism. 2021;18(1):5-99. (In Russ.). doi: https://doi.org/10.14341/omet12714

4. Российская ассоциация эндокринологов, Общество бариатрических хирургов Ожирение, Клинические рекомендации 2020

5. Malyutina SK, Serova NV, Nikitin YuP, Nasonova NV. Monitorirovanie serdechno-sosudistoi zabolevaemosti, smertnosti i ikh faktorov riska v raznykh regionakh mira (proekt VOZ MONICA). Novosibirsk: Akademicheskoe izdatel’stvo «Geo»; 2016. P. 275-292. (In Russ.)

6. Kahan S, Manson JE.Obesity Treatment, Beyond the Guidelines: Practical Suggestions for Clinical Practice. JAMA. 2019;321(14):1349-1350. doi: https://doi.org/10.1001/jama.2019.2352

7. Ng M, Fleming T, Robinson M, et al. Summary of Revisions: Standards of Medical Care in Diabetes — 2022. Diabetes Care. 2022;45(S1):S4-S7. doi: https://doi.org/10.2337/dc22-Srev7

8. Oppert JM, Ciangura C, Bellicha A. Physical activity and exercise for weight loss and maintenance in people living with obesity. Rev Endocr Metab Disord. 2023;24(5):937-949. doi: https://doi.org/10.1007/s11154-023-09805-5

9. van Baak MA, Pramono A, Battista F, Beaulieu K, Blundell JE, et al. Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses. Obes Rev. 2021;22 Suppl 4(Suppl 4):e13239. doi: https://doi.org/10.1111/obr.13239

10. Oppert JM, Bellicha A, van Baak MA, Battista F, Beaulieu K, et al. Exercise training in the management of overweight and obesity in adults: Synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group. Obes Rev. 2021;22 Suppl 4(Suppl 4):e13273. doi: https://doi.org/10.1111/obr.13273

11. Berge J, Hjelmesaeth J, Hertel JK, Gjevestad E, Småstuen MC, et al. Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial. Obesity (Silver Spring). 2021;29(2):359-369. doi: https://doi.org/10.1002/oby.23078

12. Bellicha A, van Baak MA, Battista F, Beaulieu K, Blundell JE, et al. Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic reviews and 149 studies. Obes Rev. 2021;22 Suppl 4(Suppl 4):e13256. doi: https://doi.org/10.1111/obr.13256

13. Pengyu Fu, Rongxin Zhu, Jie Jia, et al. Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway Nutrition & Metabolism. 2021;(18): 56

14. Mezzani A. Cardiopulmonary Exercise Testing: Basics of Methodology and Measurements. Ann Am Thorac Soc. 2017;14:S3-S11. doi: https://doi.org/10.1513/AnnalsATS.201612-997

15. Arutyunov GP, Kolesnikova EA, Begrambekova YL, Orlova YaA, Rylova AK, Aronov DM, et al. Recommendations for the appointment of physical training in patients with chronic heart failure. Russ J Cardiol. 2017;18(1):41–66. (In Russ.)

16. Shalnova SA, Drapkina OM. Contribution of the ESSE-RF study to preventive healthcare in Russia. Cardiovascular therapy and prevention. 2020;19(3):209-215. (In Russ.). doi: https://doi.org/10.15829/1728-8800-2020-2602

17. Персонализированная физическая реабилитация больных хронической сердечной недостаточностью — патофизиологическое обоснование и оценка эффективности Лелявина Т.А. — Дисс-я на соискание ученой степени доктора медицинских наук / Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской Федерации, 2022

18. Lelyavina T, Sitnikova M, Beresina A, et al. New Approaches to Marking Stages of Incremental Physical Work by Example of Cardiopulmonary Exercise Testing. Journal of US-China Medical Science. 2014;11:9-13

19. Poole D, Rossiter H, Brooks G. The anaerobic threshold: 50+ years of controversy. Int J Mol Sci. 2021;599(3):737-767. doi: https://doi.org/10.1113/JP279963

20. Lelyavina TA, Galenko VL, Ivanova OA, et al. Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Accompanied by Skeletal Muscle Histological Alterations. Int J Mol Sci. 2019;20(21):5514. doi: https://doi.org/10.3390/ijms20215514


Supplementary files

Review

For citations:


Lelyavina T.A., Babenko A.Y., Sonin D.L., Markina N.O., Stein K.A., Shlyakhto E.V. Effectiveness and safety of varying intensity physical training in obese patients. Obesity and metabolism. 2025;22(3):196-204. (In Russ.) https://doi.org/10.14341/omet13156

Views: 27


ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)