Features of angiogenesis as a component of reparative regeneration in diabetes mellitus

K. S. Madonov; Ya. A. Danilova; I. V. Kamalikhin; D. G. Sardaeva; T. I. Vlasova

doi:10.14341/omet13086

Features of angiogenesis as a component of reparative regeneration in diabetes mellitus

K. S. Madonov, Ya. A. Danilova, I. V. Kamalikhin, D. G. Sardaeva, T. I. Vlasova

https://doi.org/10.14341/omet13086

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Abstract

Diabetes mellitus is one of the most pressing problems of modern medicine, characterized by high morbidity (with continuous growth), a decrease in the duration and quality of life, numerous and severe complications. Among the disorders observed in diabetes mellitus, the insufficiency of angiogenesis, the process of formation of new vessels from existing ones, is noted. This process plays an important role in reparative regeneration, ensuring the formation of granulation tissue. The insufficiency of angiogenesis in diabetes mellitus causes a decrease in the rate and quality of wound healing in such patients. We conducted a literature review with the following objectives: to collect up-to-date data on the mechanisms of angiogenesis and its regulation, to identify the links of angiogenesis that are subject to the pathological influence of diabetes mellitus; and to identify potential targets of pharmacological therapy that can compensate for this effect. The results of this work will allow us to apply the data obtained in studies aimed at developing a personalized approach to the management of patients with diabetes mellitus.

Keywords

diabetes mellitus, angiogenesis, reparative regeneration, signaling molecules

About the Authors

K. S. Madonov

https://vk.com/madonoff_constantine
Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"
Russian Federation

Konstantin S. Madonov

268 Sadovaya street, 430910 Saransk, Luhovk

Competing Interests:

Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей статьи.

Ya. A. Danilova

Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"
Russian Federation

Yana A. Danilova

Saransk

Competing Interests:

I. V. Kamalikhin

Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"
Russian Federation

Ilya V. Kamalikhin

Saransk

Competing Interests:

D. G. Sardaeva

Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"
Russian Federation

Dar’ya G. Sardaeva

Saransk

Competing Interests:

T. I. Vlasova

Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"
Russian Federation

Tat'yana I. Vlasova, MD, Associated professor

Saransk

Competing Interests:

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For citations:

Madonov K.S., Danilova Ya.A., Kamalikhin I.V., Sardaeva D.G., Vlasova T.I. Features of angiogenesis as a component of reparative regeneration in diabetes mellitus. Obesity and metabolism. 2026;23(2):106-113. (In Russ.) https://doi.org/10.14341/omet13086

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