ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13086ometendo-13086Research ArticleОБЗОРЫREVIEWSОсобенности ангиогенеза как компонента репаративной регенерации при сахарном диабетеFeatures of angiogenesis as a component of reparative regeneration in diabetes mellitushttps://orcid.org/0000-0002-3709-1458МадоновК. С.MadonovK. S.

Мадонов Константин Сергеевич

430910, Саранск, Луховка, ул. Садовая, д. 268

Konstantin S. Madonov

268 Sadovaya street, 430910 Saransk, Luhovk

MKS-34@yandex.ruhttps://orcid.org/0000-0003-4173-9648ДаниловаЯ. А.DanilovaYa. A.

Данилова Яна Андреевна

Саранск

Yana A. Danilova

Saransk 

danilowa.y.a@yandex.ruhttps://orcid.org/0000-0001-6641-6437КамалихинИ. В.KamalikhinI. V.

Камалихин Илья Владимирович

Саранск

Ilya V. Kamalikhin

Saransk

ilyakama1993@yandex.ruhttps://orcid.org/0000-0001-9418-1786СардаеваД. Г.SardaevaD. G.

Сардаева Дарья Геннадьевна

Саранск

Dar’ya G. Sardaeva

Saransk

sardaieva96@mail.ruhttps://orcid.org/0000-0002-2624-6450ВласоваТ. И.VlasovaT. I.

Власова Татьяна Ивановна , д.м.н., доцент 

Саранск

Tat'yana I. Vlasova, MD, Associated professor

Saransk

v.t.i@bk.ruФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва»РоссияFederal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University"Russian Federation202618072026232106113Copyright © Мадонов К.С., Данилова Я.А., Камалихин И.В., Сардаева Д.Г., Власова Т.И., 20262026Мадонов К.С., Данилова Я.А., Камалихин И.В., Сардаева Д.Г., Власова Т.И.Madonov K.S., Danilova Y.A., Kamalikhin I.V., Sardaeva D.G., Vlasova T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13086

Сахарный диабет (СД) одна из наиболее актуальных проблем современной медицины, характеризующаяся высокой заболеваемостью с непрерывным ростом, снижением продолжительности и качества жизни, многочисленными и тяжелыми осложнениями. Среди расстройств, наблюдаемых при СД, отмечают недостаточность ангиогенеза процесса образования новых сосудов из уже имеющихся. Данный процесс играет важную роль в репаративной регенерации, обеспечивая формирование грануляционной ткани. Недостаточность ангиогенеза при СД обусловливает снижение скорости и качества заживления ран у таких пациентов. Мы провели обзор литературы со следующими целями: собрать актуальные данные о механизмах ангиогенеза и его регуляции, выявить звенья ангиогенеза, подверженные патологическому влиянию сахарного диабета; и выявить потенциальные мишени фармакологической терапии, способные компенсировать данное влияние. В статье представлена современная концепция ангиогенеза, включающая основные клетки участницы процесса и факторы, влияющие на них биомеханические и биохимические, активаторы и ингибиторы (гипотеза «ангиогенного переключателя». Отдельное внимание уделено роли сигнальных молекул. Результаты проведенной работы позволят применить полученные данные в исследованиях, направленных на разработку персонифицированного подхода к ведению пациентов с сахарным диабетом.

Diabetes mellitus is one of the most pressing problems of modern medicine, characterized by high morbidity (with continuous growth), a decrease in the duration and quality of life, numerous and severe complications. Among the disorders observed in diabetes mellitus, the insufficiency of angiogenesis, the process of formation of new vessels from existing ones, is noted. This process plays an important role in reparative regeneration, ensuring the formation of granulation tissue. The insufficiency of angiogenesis in diabetes mellitus causes a decrease in the rate and quality of wound healing in such patients. We conducted a literature review with the following objectives: to collect up-to-date data on the mechanisms of angiogenesis and its regulation, to identify the links of angiogenesis that are subject to the pathological influence of diabetes mellitus; and to identify potential targets of pharmacological therapy that can compensate for this effect. The results of this work will allow us to apply the data obtained in studies aimed at developing a personalized approach to the management of patients with diabetes mellitus.

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The authors declare that there are no conflicts of interest present.