Osobennosti funktsional'nogo sostoyaniyakory nadpochechnikov i shchitovidnoy zhelezypri metabolicheskom sindrome

Abstract

The aim. To study the functional state of adrenal cortex and thyroid gland in metabolic syndrome (MS). 186 women and 65 men
were included. Blood levels of cortisol, dehydroepiandrosterone sulphate, total thyroxin, total triiodothyronine, thyroid stimulating
hormone were studied in subjects with and without metabolic syndrome (IDF test) and their relation with MS components. The results.
75 (29,9%) of the 251 examined patients had MS. In the group with MS the levels of total thyroxin and dehydroepiandrosterone
sulphate were decreased to 1,90±0,18 microgram/milliliter vs. 2,37±0,12 microgram/milliliter (р=0,033) in patients without MS and
2,19±0,26 nmol/l vs. 2,59±0,15 nmol/l (р=0,040), respectively. The levels of dehydroepiandrosterone sulphate were inversely correlated
with the systolic blood pressure (r=-0,23, р<0,001), high density lipoprotein (r=-0,22, p=0,001), triglycerides (r=-0,14, p=0,034),
C-peptide (r=-0,44, p<0,001). The total thyroxin content was inversely correlated with low density lipoprotein (r=-0,38, р=0,026).
The patients with low dehydroepiandrosterone sulphate had higher rate of MS components. The coefficient of association between low
dehydroepiandrosterone of sulphate and MS existence was +0,39 (р=0,009). There wasnt any difference between the group with MS
and without in the level of morning cortisol in blood and after the 1 mg dexamethasone test. Conclusion. MS formation is associated with
the reduction of the levels of dehydroepiandrosterone sulphate and total thyroxin in blood, the levels of which are inversely correlated
with the elements of MS. The content of dehydroepiandrosterone sulphate in blood can be one of the indices of metabolic «wellbeing».