Obesity and stress: endocrine and social aspects of the problem in the modern Russian society

The purpose of the article is to consider stress as one of the etiological factors of obesity and metabolic syndrome. The review discusses both endocrine and social aspects of stress as a syndrome of adaptation to the current situation in Russian society.

It is emphasized that lifestyle factors contributing to the growth of overweight are gaining popularity in the society, and the high incidence of obesity is directly related to the level, quality and lifestyle of a modern man. Constant nervous tension, negative emotions, fear in conditions of abundance of food directly contributes to obesity, which is associated with a large number of other serious diseases.

Chronic hyperactivation of the hypothalamic-pituitary-adrenal axis and chronic hypersecretion of cortisol, if persistence is not a purely physiological condition. Endocrine mechanisms mediating the development of metabolic disorders on the background of chronic stress include activation of the hypothalamic-pituitary-adrenal system, changes in eating behavior, hyper-production of glucagon and triglyceride accumulation in visceral fat depots.

Processes and social changes occurring in modern society contribute to the construction of everyday socio-cultural environment characterized by increased stress. Chronic stress in combination with physical inactivity, the result of improper lifestyle of modern people, becomes an effective factor contributing to the spread among the population of Russia not only overweight, but also various forms of obesity.

It is emphasized that at the state level there is an urgent need to adopt and implement effective programs and mechanisms to ensure the population meets modern requirements and environmental standards of healthy food, rationalization of food distribution among the population, the formation of a culture of food consumption, improving the quality of life of the population and the culture of a healthy lifestyle, teaching the population the correct stress-coping behavior.

stress, obesity, overweight, metabolic syndrome, Russia, social problems/metabolism

1. Крысанова В.С., Журавлева М.В., Дралова О.В., и др. Проблема ожирения и избыточной массы тела в Российской Федерации и ее фармакоэкономическая оценка. // Альманах клинической медицины. — 2015. — Т. 1. — №1. — С. 36-41. [Krysanova VS, Zhuravleva MV, Dralova OV, et al. The problem of obesity and overweight in the Russian Federation and its pharmacoeconomic assessment. Almanac of Clinical Medicine. 2015;1(1):36-41. (In Russ).] DOI:10.18786/2072-0505-2015-1-36-41

2. Крысанова В.С., Журавлева М.В., Сереброва С.Ю. Социальная и экономическая значимость избыточной массы тела и ожирения в Российской Федерации. Основные подходы к лечению ожирения. // РМЖ. — 2015. — Т. 23. — №26. — С. 1534-1537. [Krysanova VS, Zhuravleva MV, Serebrova SY. Sotsial’naya i ekonomicheskaya znachimost’ izbytochnoy massy tela i ozhireniya v Rossiyskoy Federatsii. Osnovnye podkhody k lecheniyu ozhireniya. RMZh. 2015;23(26):1534-1537. (In Russ).]

3. Терешкина А.В. Мировые приоритеты политики в области питания. // Контентус. — 2016. — №3. — С. 10-13. [Tereshkina AV. Mirovye prioritety politiki v oblasti pitaniya. Kontentus. 2016;(3):10-13. (In Russ).]

4. Селье Г. Очерки об адаптационном синдроме. — М.: Медгиз; 1960. [Sel‘e G. Ocherki ob adaptatsionnom sindrome. Moscow: Medgiz; 1960. (In Russ).]

5. Селье Г. Стресс без дистресса. — М.: Прогресс; 1982. [Sel’e G. Stress bez distressa. Moscow: Progress; 1982. (In Russ).]

6. Marieb EN, Hoehn K. Human Anatomy & Physiology. San Francisco: Pearson Education; 2007.

7. Björntorp P. The regulation of adipose tissue distribution in humans. Int J Obes. 1996;20(4):291-302.

8. Richard D, Barkaboi D. Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity. Treat Endocrinol. 2004;3(5):269-277. DOI:10.2165/00024677-200403050-00001

9. Zimmet P, Alberti G, Courten MP. New classification and criteria for diabetes: moving the goalposts closer. Med J Austr. 1998;168(12):593-594. DOI:10.5694/j.1326-5377.1998.tb141443.x

10. International Diabetes Federation. The IDF Consensus. Worldwide Definition of the Metabolic Syndrome. Brussels: IDF; 2006.

11. Brindley D. Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome. Int J Obes Relat Metab Disord. 1995;19 Suppl 1:S69-S75.

12. Peeke PM, Chrousos GP. Hypercortisolism and obesity. Ann N Y Acad Sci. 1995;771:665-676. DOI:10.1111/j.1749-6632.1995.tb44719.x

13. Brunner EJ, Hemingway H, Walker BR, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation. 2002;106(21):2659-2665. DOI:10.1161/01.cir.0000038364.26310.bd

14. Chandola T, Britton A, Brunner E, et al. Work stress and coronary heart disease: what are the mechanisms? Eur Heart J. 2008;29(5):640-648. DOI:10.1093/eurheartj/ehm584

15. Chandola T, Brunner E, Marmot M. Chronic stress at work and the metabolic syndrome: prospective study. BMJ. 2006;332(7540):521-525. https://doi.org/10.1136/bmj.38693.435301.80

16. Edmondson D, Richardson S, Falzon L, et al. Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS One. 2012;7(6):e38915. DOI:10.1371/journal.pone.0038915

17. Bartoli F, Carrà G, Crocamo C, et al. Metabolic syndrome in people suffering from posttraumatic stress disorder: a systematic review and meta-analysis. Metab Syndr Relat Disord. 2013;11(5):301-308. DOI:10.1089/met.2013.0010

18. Rosenbaum S, Stubbs B, Ward PB, et al. The prevalence and risk of metabolic syndrome and its components among people with posttraumatic stress disorder: a systematic review and meta-analysis. Metabolism. 2015;64(8):926-933. DOI:10.1016/j.metabol.2015.04.009

19. Abraham SB, Rubino D, Sinaii N, et al. Cortisol, obesity, and the metabolic syndrome: a cross-sectional study of obese subjects and review of the literature. Obesity (Silver Spring). 2013;21(1):E105-117. DOI:10.1002/oby.20083

20. Stalder T, Kirschbaum C, Alexander N, et al. Cortisol in hair and the metabolic syndrome. J Clin Endocrinol Metab. 2013;98(6):2573-2580. DOI:10.1210/jc.2013-1056

21. Kuehl LK, Hinkelmann K, Muhtz C, et al. Hair cortisol and cortisol awakening response are associated with criteria of the metabolic syndrome in opposite directions. Psychoneuroendocrinology. 2015;51:365-370. DOI:10.1016/j.psyneuen.2014.09.012

22. Vogelzangs N, Suthers K, Ferrucci L, et al. Hypercortisolemic depression is associated with the metabolic syndrome in late-life. Psychoneuroendocrinology. 2007;32(2):151-159. DOI:10.1016/j.psyneuen.2006.11.009

23. Almadi T, Cathers I, Chow CM. Associations among work-related stress, cortisol, inflammation, and metabolic syndrome. Psychophysiology. 2013;50(9):821-830. DOI:10.1111/psyp.12069

24. Jackson SE, Kirschbaum C, Steptoe A. Hair cortisol and adiposity in a population-based sample of 2,527 men and women aged 54 to 87 years. Obesity (Silver Spring). 2017;25(3):539-544. DOI:10.1002/oby.21733

25. Bjorntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev. 2001;2(2):73-86. DOI:10.1046/j.1467-789x.2001.00027.x

26. Pasquali R, Vicennati V. Obesity and hormonal abnormalities. In: Bjorntorp P, editor. International Textbook of Obesity. Chicester: Wiley & Sons; 2001. p. 225-239.

27. Bjorntorp P. Hormonal control of regional fat distribution. Hum Reprod. 1997;12 Suppl 1:21-25. DOI:10.1093/humrep/12.suppl_1.21

28. Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71(9):742-751. DOI:10.1002/ajp.20706

29. Rebuffé-Scrive M, Walsh UA, McEwen B, Rodin J. Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism. Physiol Behav. 1992;52(3):583-590. DOI:10.1016/0031-9384(92)90351-2

30. Martí O, Martí J, Armario A. Effects of chronic stress on food intake in rats: Influence of stressor intensity and duration of daily exposure. Physiol Behav. 1994;55(4):747-753. DOI:10.1016/0031-9384(94)90055-8

31. Dallman MF, Pecoraro NC, La Fleur SE, et al. Glucocorticoids, chronic stress, and obesity. Prog Brain Res. 153:75-105. DOI:10.1016/s0079-6123(06)53004-3

32. Tataranni PA, Larson DE, Snitker S, et al. Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol. 1996;271(2 Pt 1):E317-325. DOI:10.1152/ajpendo.1996.271.2.E317

33. Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology. 2001;26(1):37-49. DOI:10.1016/s0306-4530(00)00035-4

34. Torres SJ, Nowson CA. Relationship between stress, eating behavior, and obesity. Nutrition. 2007;23(11-12):887-894. DOI:10.1016/j.nut.2007.08.008

35. Born JM, Lemmens SG, Rutters F, et al. Acute stress and food-related reward activation in the brain during food choice during eating in the absence of hunger. Int J Obes (Lond). 2010;34(1):172-181. DOI:10.1038/ijo.2009.221

36. Vicennati V, Pasqui F, Cavazza C, et al. Stress-related development of obesity and cortisol in women. Obesity (Silver Spring). 2009;17(9):1678-1683. DOI:10.1038/oby.2009.76

37. Lucassen EA, Cizza G. The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity. Curr Obes Rep. 2012;1(4):208-215. DOI:10.1007/s13679-012-0028-5

38. Лескова И.В., Мазурина Н.В., Трошина Е.А., и др. Социально-медицинские аспекты пожилого возраста: ожирение и профессиональное долгожительство. // Ожирение и метаболизм. — 2017. — Т. 14. — №4. — С. 10-15. [Leskova IV, Mazurina NV, Troshina EA, et al. Social and medical aspects of elderly age: obesity and professional longevity. Obesity and metabolism. 2017;14(4):10-14. (In Russ).] DOI:10.14341/omet2017410-15

39. Лескова И.В., Ермаков Д.Н., Матушевская Е.Г., Нишнианидзе О.О. Социально-медицинские аспекты нормализации массы тела. // Ожирение и метаболизм. — 2016. — Т. 13. — №4. — С. 49-52. [Leskova IV, Ermakov DN, Matushevskaya EG, Nishnianidze OO. Socio-medical aspects of the normalization of body mass. Obesity and metabolism. 2016;13(4):49-52. (In Russ).] DOI:10.14341/omet2016449-52

40. studme.org [интернет]. Факторы, влияющие на здоровье [доступ от 07.12.2019]. Доступ по ссылке: https://studme.org/125036/meditsina/faktory_vliyayuschie_zdorove. [Studme.org [Internet]. Health factors [cited 2019 Dec 7]. Available from: https//studme.org/125036/meditsina/faktory_vliyayuschie_zdorove. (In Russ).]

41. Спилбергер Ч.Д. Концептуальные и методологические проблемы исследования тревоги. В кн.: Стресс и тревога в спорте. — М.: Физкультура и спорт; 1983. — С. 12-24. [Spilberger CD. Kontseptual’nye i metodologicheskie problemy issledovaniya trevogi. In: Stress i trevoga v sporte. Moscow: Fizkultura i sport; 1983. p. 12-24. (In Russ).]

42. Милльман В.Э. Стресс и личностные факторы регуляции деятельности. В кн.: Стресс и тревога в спорте. — М.: Физкультура и спорт; 1983. — С. 24-46. [Millman VE. Stress i lichnostnye faktory regulyatsii deyatel’nosti. In: Stress i trevoga v sporte. Moscow; 1983. p. 24-46. (In Russ).]

43. Мерлин В.С. Лекции по психологии мотивов человека: Учебное пособие для спецкурса. — Пермь; 1971. [Merlin VS. Lektsii po psikhologii motivov cheloveka. Study Guide. Perm; 1971. (In Russ).]