Metabolic aspects of the relationship of asthma and obesity
https://doi.org/10.14341/omet9578
Abstract
Asthma and obesity are serious medical and social world problems, and their combined course is characterized by a decrease in the quality of life, an increase in the frequency and duration of hospitalization. The present review summarizes the current views on the mechanisms of formation of asthma phenotype combined with obesity, role of leptin and adiponectin imbalance in the development of systemic inflammation in obesity in the pathophysiology of asthma, it’s interrelations with metabolic syndrome. We present data that shows that syndrome is closely related not only to the debut of asthma, but also to a decrease in its control. Along with obesity, the role of other components of metabolic syndrome, in particular insulin resistance, as a predictor of asthma development is considered. Insulin resistance may be the most likely factor in the relationship between asthma and obesity, independent of other components of the metabolic syndrome. Insulin resistance associated with obesity can lead to disruption of nitric oxide synthesis. We reveal common mechanism of metabolic disorders of nitric oxide and arginine in metabolic syndrome and asthma and show that insulin resistance treatment can be therapeutically useful in patients with asthma in combination with obesity.
About the Authors
Oxana Y. KytikovaVladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration – Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
PhD
Marina V. Antonyuk
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration – Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Sc.D., Professor
Tatyana A. Gvozdenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration – Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Sc.D., Professor RAS
Tatyana Р. Novgorodtseva
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration – Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Sc.D., Professor
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Kytikova O.Y., Antonyuk M.V., Gvozdenko T.A., Novgorodtseva T.Р. Metabolic aspects of the relationship of asthma and obesity. Obesity and metabolism. 2018;15(4):9-14. (In Russ.) https://doi.org/10.14341/omet9578
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