Роль липотоксичности в патогенезе сахарного диабета 2 типа и ожирении

Ожирение является главным фактором риска развития сахарного диабета 2 типа (СД2), сердечно-сосудистых заболеваний и ассоциированных с ними коморбидных состояний. Традиционно считалось, что инсулинорезистентность определяется метаболизмом глюкозы. Однако в последние годы все больше и больше внимания уделяется обмену жирных кислот в организме, повышение уровня которых играет значительную роль в патофизиологических механизмах, связанных с инсулинорезистентностью.

ожирение, инсулинорезистентность, жирные кислоты

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