Preview

Метаболический синдром и беременность

https://doi.org/10.14341/omet201423-7

Полный текст:

Аннотация

Метаболический синдром (МС) является крайне значимой проблемой здравоохранения, с ежегодным неуклонным ростом распространенности во всем мире. Имеются данные, указывающие, что ожирение, являющееся основным компонентом МС, ассоциировано с развитием целого ряда гестационных осложнений, таких как задержка роста плода, макросомия плода, гестационный сахарный диабет, преэклампсия, синдром внезапной смерти плода. Механизмы взаимосвязи МС с развитием различных осложнений беременности активно изучаются и обсуждаются. Значимость МС при беременности определяется также его влиянием на систему гемостаза и повышением риска тромботических осложнений.

Об авторе

A V Khromilev

Медико-профилактический факультет, кафедра акушерства и гинекологии; ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова


Список литературы

1. Alipour A, Elte JW, van Zaanen HC, Rietveld AP, Cabezas MC. Postprandial inflammation and endothelial dysfunction. Biochem Soc Trans. 2007; 35(3):466-469.

2. Anfossi G, Russo I & Trovati M. Platelet dysfunction in central obesity. Nutrition, Metabolism, and Cardiovascular Diseases. 2009;19:440-419.

3. Banoo E, Sharifi F, Badamchizadeh Z, Hossein-Nezhad A, Larijani B, Mirarefin M, Fakhrzadeh H. Association of metabolic syndrome with inflammatory mediators in women with previous gestational diabetes mellitus. J Diabetes Metab Disord. 2013;12:8.

4. Bhattacharya S, Campbell DM, Liston WA. Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health. 2007;24:168.

5. Challier JC, Basu S, Bintein T. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29(3):274-281.

6. Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH. The metabolic syndrome. Endocrine Reviews. 2008;29:777-822.

7. Despre's JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rode's-Cabau J, Bertrand OF, Poirier P. Abdominalbesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:1039-1049.

8. Donath MY, Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA. Cytokine production by islets in health: cellular origin, regulation and function. Trends Endocrinol Metab. 2010;21(5):261-267.

9. Ehrenberg HM, Huston-Presley L, Catalano PM. The influence of obesity and gestational diabetesmellitus on accretion and the distribution of adipose tissue in pregnancy. Am J Obstet Gynecol. 2003;189(4):944-948.

10. Franchini M, Targher G, Montagnana M, Lippi G. Themetabolic syndrome and the risk of arterial and venousthrombosis. Thrombosis Research. 2008;122:727-735.

11. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008; 359(1):61-73.

12. Hartil K, Vuguin PM, Kruse M, et al. Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero. Pediatr Res. 2009; 66(4):368-373.

13. Heerwagen MJ, Miller MR, Barbour LA, Friedman JE. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol. 2010; 299(3):711-722.

14. Hong EG, Ko HJ, Cho YR. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes. 2009; 58(11):2525-2535.

15. Horvath B, Bodecs T, Boncz I, Bodis J. Metabolic syndrome in normal and complicated pregnancies. Metab Syndr Relat Disord. 2013 Jun;11(3):185-8.

16. Howie GJ, Sloboda DM, Kamal T, Vickers MH. Maternal nutritional history pred icts obesity in adult offspring independent of postnatal diet. J Physiol. 2009; 587(4):905-915.

17. Jacobsen AF, Skjeldestad FE, Sandset PM. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium-a register-based casecontrol study. Am J Obstet Gynecol. 2008;198:231-237.

18. Jones HN, Jansson T, Powell TL. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol. 2009;297(5):1228-1235.

19. Kidron D, Bernheim J, Aviram R. Placental findings contributing to fetal death, a study of 120 stillbirths between 23 and 40 weeks gestation. Placenta. 2009; 30(8):700-704.

20. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-1904.

21. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG. 2005; 112(4):403-408.

22. Lakshmy R. Metabolic syndrome: Role of maternal undernutrition and fetal programming. Rev Endocr Metab Disord. 2013 Sep;14(3):229-40.

23. Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011;121(6):2111-2117.

24. Madan JC, Davis JM, Craig WY, et al. Maternal obesity and markers of inflammation in pregnancy. Cytokine. 2009;47(1):61-64.

25. Mark PJ, Sisala C, Connor K, et al. A maternal high-fat diet in rat pregnancy reduces growth of the fetus and placental junctional zone, but not placental labyrinth zone growth. J Dev Origins Health Dis. 2011; 2(1):63-70.

26. Meenakshi, Srivastava R, Sharma NR, Kushwaha KP, Aditya V. Obstetric Behavior and Pregnancy Outcome in Overweight and Obese Women. The Journal of Obstetrics and Gynecology of India. 2012; 62(3):276-280.

27. Nguyen MT, Favelyukis S, Nguyen AK, et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007;282(48):35279-35292.

28. Niu JM, Lei Q, Lü LJ, Wen JY, Lin XH, Duan DM, Chen X, Zhou YH, Mai CY, Liu GC, Hou MM, Zhao LN, Yi J. Evaluation of the diagnostic criteria of gestational metabolic syndrome and analysis of the risk factors. Zhonghua Fu Chan Ke Za Zhi. 2013 Feb;48(2):92-7.

29. Nohr EA, Vaeth M, Bech BH, Henriksen TB, Cnattingius S, Olsen J. Maternal obesity and neonatal mortality according to subtypes of preterm birth. Obstet Gynecol. 2007;110(5):1083-1090.

30. Okereke NC, Huston-Presley L, Amini SB, Kalhan S, Catalano PM. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol Endocrinol Metab. 2004;287(3):472-479.

31. Palomo I, Alarcon M, Moore-Carrasco R, Argiles JM. Hemostasis alterations in metabolic syndrome. International Journal of Molecular Medicine. 2006;18:969-974.

32. Pou KM, Massaro JM, Hoffmann U. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007;16(11):1234-1241.

33. Randriamboavonjy V, Fleming I. Insulin, insulin resistance, and platelet signaling in diabetes. Diabetes Care. 2009;32:528-530.

34. Redmer DA, Luther JS, Milne JS. Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation. Reproduction. 2009;137(4):749-757.

35. Reynolds LP, Borowicz PP, Vonnahme KA. Animal models of placental angiogenesis. Placenta. 2005;26(10):689-708.

36. Roberts DJ, Post MD. The placenta in pre-eclampsia and intrauterine growth restriction. J Clin Pathol. 2008; 61(12):1254-1260.

37. Roberts VH, Smith J, McLea SA, Heizer AB, Richardson JL, Myatt L. Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta. Placenta. 2009; 30(2):169-175.

38. Salihu HM, Dunlop A, Hedayatzadeh M. Extreme obesity and risk of stillbirth among black and white gravidas. Obstet Gynecol. 2007;110:552-557.

39. Silver AE, Beske SD, Christou DD, et al. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47 expression and evidence of endothelial oxidative stress. Circulation. 2007; 115(5):627-637.

40. Stekkinger E, Scholten R, van der Vlugt MJ, van Dijk AP, Janssen MC, Spaanderman ME. Metabolic syndrome and the risk for recurrent pre-eclampsia: a retrospective cohort study. BJOG. 2013 Jul;120(8):979-86.

41. Stothard KJ, Tennant PW, Ruth B, Rankin J, Maternal overweight and obesity and the risk of congenital anomalies: A systematic review and meta-analysis. JAMA. 2009;301:636-650.

42. Taylor PD, Khan IY, Lakasing L. Uterine artery function in pregnant rats fed a diet supplemented with animal lard. Exp Physiol. 2003;88(3):389-398.

43. Thongsong B, Subramanian RK, Ganapathy V, Prasad PD. Inhibition of amino acid transport system a by interleukin-1beta in trophoblasts. J Soc Gynecol Investig. 2005;12(7):495-503.

44. Trost S, Pratley R, Sobel B. Impaired fibrinolysis and risk for cardiovascular disease in the metabolic syndrome and type 2 diabetes. Current Diabetes Reports. 2006;6:47-54.

45. Wallace JM, Milne JS, Matsuzaki M, Aitken RP. Serial measurement of uterine blood flow from mid to late gestation in growth restricted pregnancies induced by overnourishing adolescent sheep dams. Placenta. 2008;9(8):718-724.

46. Walsh JM, McGowan CA, Byrne JA, Rath A, McAuliffe FM. The association between TNF-α and insulin resistance in euglycemic women. Cytokine. 2013 Oct;64(1):208-12.

47. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003; 112(12):1821-1830.

48. Yogev Y, Catalano PM, Pregnancy and Obesity. Obstet Gynecol Clin N Am. 2009; 36:285-300.

49. Yu CK, Teoh TG, Robinson S, Obesity in pregnancy BJOG. 2006;113:1117-1125.


Для цитирования:


Khromilev A.V. Метаболический синдром и беременность. Ожирение и метаболизм. 2014;11(2):3-7. https://doi.org/10.14341/omet201423-7

For citation:


. Metabolic syndrome and pregnancy. Obesity and metabolism. 2014;11(2):3-7. (In Russ.) https://doi.org/10.14341/omet201423-7

Просмотров: 66


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)