Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation
https://doi.org/10.14341/omet2014360-61
Abstract
Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis. However, type 2 diabetes are usually associated with other diseases and associated comorbid conditions that require polifarmakologic treatment.
About the Author
Sveta Andreeva
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, postgraduate student
References
1. Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, Wang H. Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling. Mol Pharmacol 2013;85(2):249-260. Available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+1115-70-4 PubMed PMID: 24252946. doi: 10.1124/mol.113.089763.
Review
For citations:
Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation. Obesity and metabolism. 2014;11(3):60-61. (In Russ.) https://doi.org/10.14341/omet2014360-61
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