The changes of gut microbiota associated with age and lifestyle
https://doi.org/10.14341/omet201523-9
Abstract
In this review are discussed experimental and clinical data about the role of gut microbiota and its changes associated with age and lifestyle. The large intestinal microbiota plays an important role in normal bowel function and the maintenance of host health through the formation of short chain fatty acids, modulation of immune system reactivity, and development of colonization resistance. The intestinal microflora is a peculiar indicator of the condition of a microorganism reacting to age, physiological, dietary, and geographical factors from change of qualitative and quantitative structure. Studies have demonstrated that obesity and metabolic syndrome may be associated with profound microbiotal changes. Changes
in gut microbiota control metabolic endotoxemia - induced chronic inflammation,
oxidative stress, and metabolic disorder which are connected with the increased
risk of development of cardiovascular diseases and pathology associated with
age, which leads to accelerated aging. It is obvious that maintenance of a homeostasis and a normal metabolism is impossible without restoration of a variety of normal associations of intestinal microorganisms.
About the Authors
Lilit Vanikovna Egshatyan
Federal State Institution «National Research Center for Preventive Medicine» of the Ministry Healthcare of the Russian Federation
Russian Federation
PhD, researcher at the Department of studying the aging process and prevention of age-associated diseases
Russian Federation
PhD, researcher at the Department of studying the aging process and prevention of age-associated diseases
Olga Nikolaevna Tkacheva
Federal State Institution «National Research Center for Preventive Medicine» of the Ministry Healthcare of the Russian Federation
Russian Federation
MD, Ph.D. Deputy Director for Research and Clinical Work
Russian Federation
MD, Ph.D. Deputy Director for Research and Clinical Work
Lyudmila Ivanovna Kafarskaya
The Russian National Research Medical University named after N.I. Pirogov
Russian Federation
MD, Ph.D., Professor, Head of the Microbiology and Virology Department
Russian Federation
MD, Ph.D., Professor, Head of the Microbiology and Virology Department
Andrey Nikolaevich Shkoporov
The Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Ph.D., Senior Researcher at the Laboratory of Microbiology and Biosafety
Russian Federation
Ph.D., Senior Researcher at the Laboratory of Microbiology and Biosafety
Aleksandr Viktorovich Tyakht
Federal Medical & Biological Agency SRI of Physical-Chemical Medicine
Russian Federation
Junior Researcher at the Laboratory of Bioinformatics
Russian Federation
Junior Researcher at the Laboratory of Bioinformatics
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Egshatyan L.V., Tkacheva O.N., Kafarskaya L.I., Shkoporov A.N., Tyakht A.V. The changes of gut microbiota associated with age and lifestyle. Obesity and metabolism. 2015;12(2):3-9. (In Russ.) https://doi.org/10.14341/omet201523-9
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