Secondary obesity
https://doi.org/10.14341/omet2014142-47
Abstract
Hyperinsulinism and insulin resistance, hypogonadism in men and women are often associated with obesity and may be its consequences and to be a primary preceding the development of overweight. A characteristic feature of the endocrine obesity is an increase in body weight due to visceral fat with redistribution on central type, accompanied by the development of the metabolic and endocrine disorders. Mechanisms of obesity in various hormonal disturbances are different. In general in the vast majority approaches of obesity treatment do not differ from generally accepted. Adequate correction of hormonal disorders can reduce body weight and contribute to the improvement of endocrine-metabolic parameters.
About the Authors
M FadeevaUl. Dmitriya Ulyanova dom 11, Moscow, Russian Federation, 117036
L Savelieva
Ul. Dmitriya Ulyanova dom 11, Moscow, Russian Federation, 117036
References
1. Ожирение: этиология, патогенез, клинические аспекты. Руководство для врачей. Под редакцией И.И. Дедова, Г.А. Мельниченко. - М.: ООО «Медицинское информационное агентство», 2004.
2. Синдром поликистозных яичников: Руководство для врачей. Под редакцией И.И. Дедова, Г.А. Мельниченко. - М.: ООО «Медицинское информационное агентство», 2007.
3. Cметник В.П. Половые гормоны и жировая ткань. Ожирение и метаболизм. 2007; 3: 17-22.
4. Ahima R.S. (ed.) Metabolic basis of obesity. Springer Science + Business Media. LLC 2011; 139-154.
5. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews. 1997; 18(6): 774-800.
6. Kirchengast S., Huber J. Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Human Reproduction 2001; 16 (6): 1255-1260.
7. Liu P.Y., Wishart S.M., Celermajer D.S. et al. Do reproductive hormones modify insulin sensitivity and metabolism in older man? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin. Eur J Endocrinol. 2003; 148: 55-66.
8. Malkin C.J., Pugh P.J., Kapoor D. et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metabolism. 2004; 89: 3313-3318.
9. Marin P., Arver S. Androgen and abdominal obesity. Bailliere’s Clin Endocrinol Metab. 1998; 12: 441-51.
10. Milewicz A., Bidzinska B., Sidorovicz A. Perimenopausal obesity. Gynecol Endocrinol. 1996; 10: 285-91.
11. Muraleedharan V., Hugh Jones T. Testosterone and the metabolic syndrome. Ther Adv Endocrinol Metab. 2010; 1(5): 207-223.
12. Rebuffe-Scrive M., Marin P., Bjӧrntorp P. Effect of testosterone on abdominal adipose tissue in men. Int J Obes Relat Metab Disord. 1998; 83: 3277-84.
13. Saiki A., Miyashita Y., Wakabayashi M. et al. Reduction of visceral adiposity after operation in a subject with insulinoma. J Atheroscler Thromb. 2004; 11(4): 209-214.
14. Smith M.R., Finkelstein J.S., McGovern F.J. et al. Changes in body composition during androgen deprivation therapy for prostate cancer. The Jounal of Clinical Endocrinology and Metabolism. 2002; 87 (2): 599-603.
15. Tsai E.C., Boyko E.J., Leonetti D.L., Fujimoto W.Y. Low serum testosterone level as predictor of increased visceral fat in Japanese-American men. Int J Obes. 2000; 24: 485-91.
16. Weaver J.U. Classical endocrine diseases causing obesity. Korbonits M (ed): Obesity and Metabolizm. Front Horm Res. Basel, Karger. 2008; 36: 212-228.
17. Wing R., Matthews K., Kuller L. et al. Weight gain at the time of menopause. Arch Int Med. 1991; 151: 97-102.
18. Zitzmann M., Gromoll J., von Eckardstein A., Nieschlag E. The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia. 2003; 46: 31-39.
Review
For citations:
, Secondary obesity. Obesity and metabolism. 2014;11(1):42-47. (In Russ.) https://doi.org/10.14341/omet2014142-47
Views:
698
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
