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Фермент сукцинатдегидрогеназа (SDH) и его роль при наследственных аденомах гипофиза

https://doi.org/10.14341/omet2013410-15

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Аннотация

Несмотря на активные исследования в области семейных аденом гипофиза и характеристику пяти наследственных синдромов, более чем у 80-95% пациентов с изолированными семейными аденомами гипофиза (FIPA) генетические дефекты не найдены. Кроме того, в литературе описано более 25 случаев сосуществования феохромоцитом и гипофизарных аденом, что на сегодняшний день не объединено ни в один синдром, генетические дефекты такого сосуществования также не определены. Однако предполагается, что в гипофизарном туморогенезе, при исключении других возможных генетических причин, могут принимать участие вариантные зародышевые мутации SDH, что представляется важным аспектом изучения в ближайшей перспективе. Так, зародышевые мутации SDH были обнаружены у пациентов с неактивной аденомой гипофиза и гигантской соматотропиномой гипофиза с агрессивным характером роста. Продолжение генетических исследований, изучение мутаций в генах SDHD, SDHB, SDHC, SDHA и их распространенности у пациентов с семейными аденомами гипофиза или с фенотипами множественных эндокринных неоплазий без мутаций в генах MEN1, CDKN1B, PRKAR1A, AIP, а также гистологические исследования удаленных тканей могут обеспечить большую ясность о роли мутаций в SDH в эндокринном, и, в частности, гипофизарном туморогенезе.

Об авторах

Iu V Pankratova

аспирант отделения нейроэндокринологий и остеопатий


E G Przhiyalkovskaya

научный сотрудник отделения нейроэндокринологий и остеопатий


E A Pigarova

старший научный сотрудник отделения нейроэндокринологий и остеопатий


L K Dzeranova

главный научный сотрудник, д.м.н. отделения нейроэндокринологий и остеопатий


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Для цитирования:


Pankratova I.V., Przhiyalkovskaya E.G., Pigarova E.A., Dzeranova L.K. Фермент сукцинатдегидрогеназа (SDH) и его роль при наследственных аденомах гипофиза. Ожирение и метаболизм. 2013;10(4):10-15. https://doi.org/10.14341/omet2013410-15

For citation:


., ., ., . The enzyme succinate dehydrogenase (SDH) and its role in hereditary pituitary adenomas. Obesity and metabolism. 2013;10(4):10-15. (In Russ.) https://doi.org/10.14341/omet2013410-15

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