The impact of early intensive glucose control for prophylaxis of complications of type 2 diabetes mellitus (results of UKPDS study and 10-year follow-up study)
https://doi.org/10.14341/2071-8713-5312
Abstract
At the present time diabetes mellitus (DM) is a main noninfectious disease that not only significantly influences quality of life and life expectancy of every patient but also represents a heavy burden for the healthcare system. Medico social significance of DM is defined by high prevalence of this disease in population and high risk of its specific macro- and microvascular complications. According to latest data the main chain in the development of all specific complications of DM is chronic hyperglycemia, the important role belongs also to arterial hypertension and dyslipidemia. The multicenter randomized controlled study UKPDS assessed the influence of levels of hyperglycemia and arterial pressure as well as common methods of their corrections on development of complications of type 2 DM. The results of the UKPD study showed the significance of the intensive control of blood glucose and arterial pressure for the prophylaxis of type 2 DM complications and lethal outcomes. These observations allowed development of contemporary recommendations for treatment patients with type 2 DM and defined the target levels of HbAlc (<7,0%) and arterial pressure (<130/80 mm Hg). After the end of the randomized part of the study its participants were observed for 10 years (10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes) to investigate does the intensive therapy have long-term effect on complications of type 2 DM. The results showed the maintenance of positive effects of intensive glucose lowering therapy on the risk of DM complications and lethal outcomes.
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, , , The impact of early intensive glucose control for prophylaxis of complications of type 2 diabetes mellitus (results of UKPDS study and 10-year follow-up study). Obesity and metabolism. 2009;6(2):12-18. (In Russ.) https://doi.org/10.14341/2071-8713-5312
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