Effect of chronic hyperglycaemia on the parameters of protein, lipid metabolism and platelet-coagulation haemostasis in acromegaly
https://doi.org/10.14341/2071-8713-5299
Abstract
The aim of the research. Assessing the impact of chronic hyperglycemia on the parameters of the protein, lipid metabolism
and platelet-coagulation haemostasis in patients with active phase of acromegaly. Materials and methods: The research included 58 patients
with the active phase of acromegaly (36 women and 28 men), median age 50 (43, 57) years, disease duration 9.0 (5.0, 15.0) years,
26 of whom had verified diabetes mellitus. Results: Biochemical parameters and parameters of haemostasis in patients with active
phase of acromegaly with normoglycemia differed from the control group by higher levels of total cholesterol, high-density lipoproteins,
an increase in the average volume of platelet aggregation and enhancement of their function. The presence of diabetes mellitus
was accompanied by the increase in concentration of total cholesterol, triglycerides, decrease in high-density lipoproteins, and increase
in fibrinogen concentration, soluble fibrin-monomeasured complexes, as well as reduction of disaggregation properties of platelets
and enhancement of ejection reactions. Conclusion: The presence of diabetes mellitus with acromegaly can be regarded as a significant
risk factor for atherogenic dyslipidemia, hyperfibrinogenemia and platelet disfunction.
and platelet-coagulation haemostasis in patients with active phase of acromegaly. Materials and methods: The research included 58 patients
with the active phase of acromegaly (36 women and 28 men), median age 50 (43, 57) years, disease duration 9.0 (5.0, 15.0) years,
26 of whom had verified diabetes mellitus. Results: Biochemical parameters and parameters of haemostasis in patients with active
phase of acromegaly with normoglycemia differed from the control group by higher levels of total cholesterol, high-density lipoproteins,
an increase in the average volume of platelet aggregation and enhancement of their function. The presence of diabetes mellitus
was accompanied by the increase in concentration of total cholesterol, triglycerides, decrease in high-density lipoproteins, and increase
in fibrinogen concentration, soluble fibrin-monomeasured complexes, as well as reduction of disaggregation properties of platelets
and enhancement of ejection reactions. Conclusion: The presence of diabetes mellitus with acromegaly can be regarded as a significant
risk factor for atherogenic dyslipidemia, hyperfibrinogenemia and platelet disfunction.
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Review
For citations:
, Effect of chronic hyperglycaemia on the parameters of protein, lipid metabolism and platelet-coagulation haemostasis in acromegaly. Obesity and metabolism. 2011;8(4):23-27. (In Russ.) https://doi.org/10.14341/2071-8713-5299
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