Preview

Obesity and metabolism

Advanced search

An impact of overweight and obesity on the risk factors for breast cancer in postmenopausal women

https://doi.org/10.14341/2071-8713-4965

Abstract

Breast cancer is the leading cause of death in the female population of Russia. Postmenopausal breast cancer is associated with obesity. The article presents data on the significant effect of fat tissue on the risk factors for breast cancer in postmenopausal women.

About the Authors

E Troshina

prof., d.m.n., zav. otdeleniem terapii s gruppoy ozhireniya


P Rumyantsev

prof., d.m.n.


M Altashina

kl. ordinator


A Plokhaya

st.n.s., k.m.n., otdelenie terapii s gruppoy ozhireniya


References

1. И.И. Дедов, С.А. Бутрова, М.А. Берковская. Потенциальные возможности метформина в профилактике и лечении онкологических заболеваний у больных сахарным диабетом 2 типа // Ожирение и метаболизм. – 2011. – №1. – Р. 40–49.

2. Aloulou N, Bastuji-Garin S, Le Gouvello S, et al. Involvement of the leptin receptor in the immune response in intestinal cancer // Cancer Research. – 2008. – № 68(22). – Р. 9413–22.

3. Artwohl M, Roden M, Holzenbein T, Freudenthaler A, Waldhausl W, Baumgartner-Parzer SM. Modulation by leptin of proliferation and apoptosis in vascular endothelial cells // International Journal of Obesity and Related Metabolic Disorders. – 2002. – № 26(4). – Р. 577–80.

4. Bachelot T, Ray-Coquard I, Menetrier-Caux C, Rastkha M, Duc A, Blay JI. Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients // British Journal of Cancer. – 2003. – № 88. – Р. 1721–1726.

5. Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy // Nature Reviews Cancer. – 2004. – № 4. – Р. 335–48.

6. Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S. Regulation of aromatase expression in estrogen-positive breast and uterine disease: from bench to treatment // Pharmacology Reviews. – 2005. – № 57. – Р. 359–353.

7. Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER. A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription // J Clinical Endocrinology Metabolism. – 1993. – № 77. – Р. 1622–1628.

8. Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF // Proceedings of the National Academy of Sciences of the Unated States of America (PNAS). – 2001. – № 98(11). – Р. 6390–5.

9. Carmichael AR. Obesity and prognosis of breast cancer // Obesity Reviews. – 2006. – №7(4). – Р. 333–340.

10. Carmichael AR. Obesity as a risk factor for development and poor prognosis of breast cancer // An International Journal of Obstetrics & Gynaecology. – 2006. – №113. – Р. – 1160–1166.

11. Catalano S, Mauro L, Marsico S, Giordano C, Rizza P, Rago V, Montanaro D, Maggiolini M, Panno ML, Ando S. Leptin induces, via ERK1ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells // The Journal of Biological Chemistry. – 2004. – № 279. – Р. 19908–19915.

12. Cleary M.P., Grossmann M.E. Minireview: obesity and breast cancer: the estrogen connection // Endocrinology. – 2009. – №150. – Р. 2537–2542.

13. Coppack SW. Pro-inflammatory cytokines and adipose tissue // Proceedings of the Nutrition Society. – 2001. – № 60. – Р. 349–356.

14. Daling JR, Malone KE, Doody DR, Johnson LG, Gralow JR, Porter PL. Relation of body mass index to tumor markers and survival among women with invasive ductal breast carcinoma // Cancer 2001. – № 92. – Р. 720–729.

15. Dirat B, Bochet L, Dabek M, et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion // Cancer Research. – 2011. – № 71(7). – Р. 2455–2465.

16. Dirat B, Bochet L, Escourrou G, Valet P, Muller C. Unraveling the obesity and breast cancer links: a role for cancer-associated adipocytes? // Endocrine Development. – 2010. – №19. – Р. 45–52.

17. Elliot BE, Tam SP, Dexter D, Chen ZQ. Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: effect of estrogen and progesterone // International Journal of Cancer. – 1992. – № 51. – Р. – 416–424.

18. Geisler J, Haynes B, Ekse D, Dowsett M, Lonning PE. Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels // The Journal of Steroid Biochemistry and Molecular Biology. – 2007. – № 104. – Р. 27–34.

19. Grano M, Mori G, Minielli V, Cantatore FP, Colucci S, Zallone AZ. Breast cancer cell line MDA-231 stimulates osteoclastogenesis and bone resorption in human osteoclasys // Boichemical and Biophysical Research Communications 2000. – № 270. – Р. 1097–1100.

20. Grundy SM, Brewer HB, Jr., Cleeman JI, Smith SC, Jr., Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition // Arteriosclerosis, Thrombosis, and Vascular Biology. – 2004. – № 24(2). – Р. 13–8.

21. Hu X, Juneja SC, Maihle NJ, Cleary MP. Leptin – a growth factor in normal and malignant breast cells and for normal breast mammary gland development // Journal of the National Cancer Institute. – 2002. – № 94. – Р. 1704–1711.

22. Huang L, Li C. Leptin: a multifunctional hormone // Cell Research. – 2000. – № 10(2). – Р. 81–92.

23. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression // Journal of Clinical Oncology. – 2010. – № 28(26). – Р. 4058–4065.

24. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling // Nature Cell Biology. – 2002. – № 4. – Р. 648–57.

25. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival // Cell. – 2003. – № 115. – Р. 577–90.

26. Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer // Clinical Cancer Research. – 2004. – № 10. – Р. 4325–4331.

27. Iyengar P, Combs TP, Shan SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP, Pestell RG, Scherer PE. Adipocyte-secreted factors synergistically promote mammary tumorogenesis through induction of antiapoptotic transcriptional programs and proto-oncogene stabilization // Oncogene. – 2003. – № 22. – Р. 6408–6423.

28. Lorincz AM, Sukumar S. Molecular links between obesity and breast cancer // Endocrine-Related Cancer. – 2006. – № 13. – Р. 179–292.

29. Macciò A, Madeddu C. Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications // ScientificWorldJournal. – 2011. – №11. – Р. 2020–36.

30. Machinal-Quelin F, Dieudonne MN, Pecquery R, Leneveu MC, Giudicelli Y. Direct in vitro effects of androgens and estrogenes on ob gene expression and leptin secretion in human adipose tissue // Endocrine. – 2002. – № 18. – Р. 179–184.

31. Manabe Y, Toda S, Miyazaki K, Sugihara H. Mature adipocites, but not preadipocites, promote the growth of breast carcinoma cells in gen collagen matrix culture through cancer-stromal cell interactions // The Journal of Pathology. – 2003. – № 201. – Р. 221–228.

32. Mantrozors CS, Bolhke K, Moschos S, Cramer DW. Leptin in relation to carcinoma in situ of the breast cancer: a study of premenopausal cases and controls // International Journal of Cancer. – 1999. – № 80. – Р. 523–526.

33. Martinez J, Cifuentes M. Adipose Tissue and Desmoplastic Response in Breast Cancer // Breast Cancer – Carcinogenesis, Cell Growth and Signalling Pathways. – 2011, InTech. – Р. – 447–456.

34. Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells // Cell Cycle. – 2010. – № 9(16). – Р. 3256–3276.

35. Matsuzawa Y. Adiponectin: identification, physiology and clinical relevance in metabolic and vascular disease // Atherosclerosis Supplements. – 2005. – № 6. – Р. 7–14.

36. Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR // Proceedings of the National Academy of Sciences of the Unated States of America (PNAS). – 2001. – № 98. – Р. 10314–9.

37. Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N. mTOR signaling: implications for cancer and anticancer therapy // British Journal of Cancer. – 2006. – № 94. – Р. 195–9.

38. Purohit A, Ghilchik MW, Duncan L, Wang DY, Singh A, Walker MM, Reed MJ. Aromatase activity and interleukin 6 production by normal and malignant breast tissues // The Journal of Clinical Endocrinology and Metabolism. – 1995. – № 80. – Р. 3052–3058.

39. Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update // Clinical Endocrinology (Oxf). – 2006. – № 64(4). – Р. 355–65.

40. Sachdev D, Yee D. The IGF system and breast cancer // Endocrine-Related Cancer. – 2001. – № 8. – Р. 197–209.

41. Schaffler A, Scholmerich J, Buechler C. Mechanisms of desease: adipokines and breast cancer – endocrine and paracrine mechanisms that connect adiposity and breast cancer // Nature Clinical Practice. – 2007. – № 3. – Р. 345–354.

42. Sheen-Chen SM, Liu YW, Eng HL, Chou FF. Serum levels of hepatocyte growth factor in patients with breast cancer // Cancer Epidemiology, Biomarkers and Prevention. – 2005. – № 14. – Р. 715–717.

43. Simons PJ, van den Pangaart PS, van Roomen CP, Aerts JM, Boon L. Cytokine-mediated stimulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleikin-1beta-treated human preadipocytes are potent leptin producers // Cytokine. – 2005. – № 32. – Р. 94–103.

44. Slattery ML, Sweeney C, Wolff R, et al. Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States // Breast Cancer Research and Treatment. – 2007. – №104(2). – Р. 197–209.

45. Tan J, Buache E, Chenard M-P, Nassim D-Y, Rio M-C. Adipocyte is a non-trivial, dynamic partner of breast cancer cells // International Journal of Developmental Biology. – 2011. – № 55. – Р. 851–859.

46. Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. // Circulation Research. – 2007. – № 100. – Р. 328–41.

47. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue // British Journal of Nutrition. – 2004. – № 92(3). – Р. 347–55.

48. Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells // Cell Cycle. – 2009. – № 8(1). – Р. 88–96.

49. Vona-Devis L, Howard McNatt M, Rose DP. Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer // Obesity Reviews. – 2007. – № 8. – Р. 395–408.

50. Vona-Devis L, Rose DP. Adipokines as endocrine, paracrine and autocrine factors in breast cancer risk and progression // Endocrine- Related Cancer. – 2007. – № 14. – Р. 189–206.

51. Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley LE. Circulating interleukin-6 in relation to adiposity, insukin action, and insulin secretion // Obesity Research. – 2001. – № 9. – 414–417.

52. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufell F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase // Nature Medicine. – 2002. – № 8. – Р. 1288–1295.

53. Yee D, Lee AV. Crosstalk between the insulin-like growth factors and estrogens in breast cancer // Journal Mammary Gland Biology and Neuplasia. – 2000. – № 5. – Р. 107–115.

54. Yin N, Wang D, Zhang H, Yi X, Shi B, Wu H, Wu G, Wang X, Shang Y. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin // Cancer Research. – 2004. – № 64. – Р. 5870–5875.


Review

For citations:


 ,  ,  ,   An impact of overweight and obesity on the risk factors for breast cancer in postmenopausal women. Obesity and metabolism. 2012;9(3):3-10. (In Russ.) https://doi.org/10.14341/2071-8713-4965

Views: 503


ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)