Urovni rezistina, adiponektinai insulinorezistentnosti u patsientov s raznoystepen'yu narusheniy uglevodnogo obmena
https://doi.org/10.14341/2071-8713-4838
Abstract
The basis of type 2 diabetes is obesity and insulin resistance. Fat tissue is hormonaly active system which produces adiponectin,
resistin and other adipokines. These substances participate in development of insulin resistance. The article presents the results of a study
conducted to examine the role of adiponectin, resistin in development of insulin resistance in patients with IGT and type 2 diabetes.
The reduction of adiponectin level and insulin resistance was found in women suffering from IGF or type 2 diabetes and in men with
only type 2 diabetes. Resistin levels were increased in the examined patients with IGT and with type 2 diabetes.
resistin and other adipokines. These substances participate in development of insulin resistance. The article presents the results of a study
conducted to examine the role of adiponectin, resistin in development of insulin resistance in patients with IGT and type 2 diabetes.
The reduction of adiponectin level and insulin resistance was found in women suffering from IGF or type 2 diabetes and in men with
only type 2 diabetes. Resistin levels were increased in the examined patients with IGT and with type 2 diabetes.
References
1. Метаболический синдром / Под ред. чл.-корр. РАМН г.Е. Ройтберга. - М.: МЕД-пресс-Информ, 2007. - 224 с.
2. Fernández-Real J.M., Botas-Cervero P., López-Bermano A., Casamitjana R., Funahashi T., Delgado E., Kihara S., Ricart W. Adiponectin is independently associated with glycosylated haemoglobin // Eur J Endocrinol. - 2004. - № 150 (2). - Р. 201-5.
3. Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R.E., Tataranni P.A. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia // J Clin Endocrinol Metab. - 2001. - № 86 (5). - Р. 1930-5.
4. Cnop M., Havel P.J., Utzschneider K.M., Carr D.B., Sinha M.K., Boyko E.J., Retzlaff B.M., Knopp R.H., Brunzell J.D., Kahn S.E. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex // Diabetologia. - 2003. - № 46 (4). - Р. 459-69.
5. Hivert M.F., Sullivan L.M., Fox C.S., Nathan D.M., D'Agostino R.B. Sr., Wilson P.W., Meigs J.B. Associations of adiponectin, resistin, and tumor necrosis factoralpha with insulin resistance // J Clin Endocrinol Metab. - 2008. - № 93 (8). - Р. 3165-72. Epub 2008 May 20.
6. Burnett M.S., Devaney J.M., Adenika R.J. Cross-Sectional Associations of Resistin, Coronary Heart Disease, and Insulin Resistance // J. Clin. Endocrinol. Metab. - 2006. - № 91 (1). - Р. 64-68.
7. Mojiminiyi O.A., Abdella N.A. Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus // Scand J Clin Lab Invest. - 2007. - № 67 (2). - Р. 215-25.
8. Farvid M.S., Ng T.W.C., Chan D.C., Barret P.H.R., Watts G.F. Associations of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidemia // Diabetes, obesity and metabolism. - 2005. - № 4. - P. 406-413.
9. Koebnick C., Wagner K., Garcia A.L., Gruendel S., Lahmann P.H. Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism // Int. J. Obesity. - 2006. - № 30 (7). - P. 1097-1103.
10. Diez J.J., Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease // Eur.J. of Endocrinology. - 2003. - Vol. 148. - P. 293-300.
11. Zhang J.-L., Qin Y.W., Qiu J.-L., Zou D.-J. Serum resistin level in essential hypertension patients with different glucose tolerance // Diabet Med. - 2003. - № 20 (10).
Review
For citations:
, , Urovni rezistina, adiponektinai insulinorezistentnosti u patsientov s raznoystepen'yu narusheniy uglevodnogo obmena. Obesity and metabolism. 2011;8(3):57-60. (In Russ.) https://doi.org/10.14341/2071-8713-4838
Views:
521
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
