Adipocytes and the role of their hormonal activity in the development of obesity
V. V. Shishkina,
A. A. Glukhov,
A. A. Andreev,
N. S. Kovalenko,
M. V. Eliseev,
A. Yu. Laptiyova,
A. P. Ostroushko,
A. Yu. Frolov https://doi.org/10.14341/omet13149
Abstract
In the world, more than 2 billion people are overweight, which makes up 30-39% of the world’s population. Against the background of existing obesity, comorbid pathology is progressing in patients.
The article provides information on the pathogenetic basis of obesity. The features of functioning and hormonal activity of adipocytes are described. The mechanisms of the effect of hormones and metabolically active substances produced by adipocytes on the human body, the development of comorbid pathology are considered. all of them have been studied in detail.
Based on the analysis, it can be assumed that unexplored metabolites secreted by adipose tissue may play a key role in the regulation of metabolism, inflammatory processes and even in the development of various diseases, including obesity. The low effectiveness of obesity treatment, despite financial costs exceeding 2 trillion US dollars annually, actualizes the revision of existing approaches, the development of new treatment methods and medicines based on a deeper understanding of the pathogenetic foundations of obesity.
About the Authors
V. V. Shishkina
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Victoria V. Shishkina, PhD, Associate Professor
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
A. A. Glukhov
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Alexander A. Glukhov, MD, Professor
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
A. A. Andreev
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Alexander A. Andreev, MD, Professor
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
N. S. Kovalenko
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Natalia S. Kovalenko, applicant
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
M. V. Eliseev
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Maxim V. Eliseev, applicant
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
A. Yu. Laptiyova
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Anastasia Yu. Laptiyova, PhD, Associate Professor, 5th year student of the medical faculty
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
A. P. Ostroushko
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Anton P. Ostroushko, PhD, Associate Professor
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
A. Yu. Frolov
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Alexandr Yu. Frolov, student
Voronezh
Competing Interests:
Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием
настоящей статьи
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Shishkina V.V., Glukhov A.A., Andreev A.A., Kovalenko N.S., Eliseev M.V., Laptiyova A.Yu., Ostroushko A.P., Frolov A.Yu. Adipocytes and the role of their hormonal activity in the development of obesity. Obesity and metabolism. 2025;22(3):245-254. (In Russ.) https://doi.org/10.14341/omet13149
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