Nutrient molecules affecting the white-to-beige adipose tissue transition
https://doi.org/10.14341/omet13070
Abstract
Obesity is one of the most important health problems. Body weight can be controlled through a combination of a healthy diet and physical activity, but hypertrophic obesity is often complicated by other comorbidities such as type 2 diabetes mellitus (T2DM), cardiovascular disease, hypertension and various forms of arthritis. If intense physical activity is contraindicated for patients, then alternative approaches to combat obesity can be developed. The discovery of beige adipocytes in white adipose tissue has attracted attention to their use as a target for therapy. There are molecules of various origin that are capable of modulating the formation of beige adipocytes by interacting with critical signaling cascades, leading to increased thermogenesis. One such approach would be to stimulate the transition of white adipose tissue cells into more catabolically active beige cells using nutrients and small molecule drugs.
About the Authors
V. S. Egorova
Division of Medical Biotechnology, Research Center for Translational Medicine, Sirius University of Science and technology
Russian Federation
Competing Interests:
Russian Federation
Vera S. Egorova - PhD, Researcher.
Sirius
Researcher ID IWD-9182-2023; Scopus Author ID 57195327345
Competing Interests:
None
D. T. Gurtsieva
Division of Gene Therapy, Research Center for Translational Medicine, Sirius University of Science and technology
Russian Federation
Competing Interests:
Russian Federation
Dzerassa T. Gutrsieva - PhD student, Junior researcher.
Sirius
Researcher ID KSL-9382-2024; Scopus Author ID 58848190600
Competing Interests:
None
A. D. Egorov
https://siriusuniversity.ru/university-in-faces/nauchnii-tsentr-translyatsionnoi-meditsini/aleksandr-dmitrievich-egorov0000-0002-5953-8097
Division of Gene Therapy, Research Center for Translational Medicine, Sirius University of Science and technology
Russian Federation
Competing Interests:
Division of Gene Therapy, Research Center for Translational Medicine, Sirius University of Science and technology
Russian Federation
Alexander D. Egorov - PhD, Leading researcher, group leader.
1 Olympic ave., 354340 Sirius
Researcher ID A-7393-2014; Scopus Author ID 55568681100
Competing Interests:
None
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1. Figure 1. Influence of various factors on the conversion of white adipose tissue to beige adipose | |
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Egorova V.S., Gurtsieva D.T., Egorov A.D. Nutrient molecules affecting the white-to-beige adipose tissue transition. Obesity and metabolism. 2024;21(3):295-301. (In Russ.) https://doi.org/10.14341/omet13070
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