Obesity and the nervous system
K. V. Antonova,
M. M. Tanashyan,
A. A. Raskurazhev,
N. E. Spryshkov,
A. A. Panina,
O. V. Lagoda,
A. S. Ametov,
E. A. Troshina https://doi.org/10.14341/omet13019
Abstract
The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with the pandemic spread of obesity. The pathogenesis of damage to the nervous system (NS) is considered in detail. The influence of the main metabolic factors on the development of cerebrovascular diseases (CVD), incl. neuroinflammation, changes in hemostasis, etc. is demonstrated. The problem of the development of cognitive dysfunction against the background of obesity due to the formation of atrophic processes in brain structures is highlighted. Modern possibilities of evaluation and modulation of eating behavior due to brain stimulation using functional magnetic resonance imaging (fMRI) and navigational rhythmic transcranial magnetic stimulation (rTMS) are described.
The problem of cerebrometabolic health is presented as a continuum of metabolic and cerebral disturbances. The mechanisms of interaction between the two most important systems of the body allow us to consider the changes that occur in them as an integral neuroendocrine alteration.
About the Authors
K. V. Antonova
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Ksenia V. Antonova - MD, PhD.
80 Volokolamskoe Shosse, 125367 Moscow
Researcher ID: J-9971-2016; Scopus Author ID: 7004672742
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
M. M. Tanashyan
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Marine M. Tanashyan - MD, PhD, Professor.
Moscow
Researcher ID: F-8483-2014; Scopus Author ID: 6506228066
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
A. A. Raskurazhev
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Anton A. Raskurazhev - MD, PhD.
Moscow
Researcher ID: K-7636-2012; Scopus Author ID: 57191092653
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
N. E. Spryshkov
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Nikita E. Spryshkov.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
A. A. Panina
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Anastasiya A. Panina.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
O. V. Lagoda
Research Center of Neurology
Russian Federation
Competing Interests:
Russian Federation
Olga V. Lagoda - MD, PhD.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
A. S. Ametov
Russian Medical Academy of Continuing Professional Education
Russian Federation
Competing Interests:
Russian Federation
Alexander S. Ametov - MD, PhD, Professor.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
E. A. Troshina
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Ekaterina A. Troshina - MD, PhD, Professor.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Трошиной Е.А.
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1. Figure 1. Model of hypothalamic gliosis in humans (based on the article Sewaybricker LE, Huang A, Chandrasekaran S, Melhorn SJ, Schur EA. The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans [21]). | |
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| Type | Исследовательские инструменты | |
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2. Figure 2. Pathogenesis of neurological diseases in obesity. | |
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| Type | Исследовательские инструменты | |
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Antonova K.V., Tanashyan M.M., Raskurazhev A.A., Spryshkov N.E., Panina A.A., Lagoda O.V., Ametov A.S., Troshina E.A. Obesity and the nervous system. Obesity and metabolism. 2024;21(1):68-78. (In Russ.) https://doi.org/10.14341/omet13019
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