Dihydrotachysterol: a bad choice in the treatment of chronic hypoparathyroidism
https://doi.org/10.14341/omet12882
Abstract
Hypoparathyroidism is an endocrine disease caused by damage of the parathyroid glands and characterized by underproduction of parathyroid hormone. This can lead to severe hypocalcemia and its associated complications. The chronic hypoparathyroidism requires lifelong therapy including calcium and vitamin D analogues. The goal of treatment is to maintain the target parameters of phosphorus-calcium metabolism. At the same time, there is a risk of iatrogenic hypercalcemia on the standard therapy, up to the hypercalcemic crisis, often complicated by the acute renal failure. Moreover, chronic hypercalcemia acts as a predisposing factor for nephrolithiasis, nephrocalcinosis, chronic renal failure including pre- and dialysis stages.
Dihydrotachysterol is a synthetic analogue of vitamin D, which was previously widely prescribed for hypocalcaemic hypoparathyroidism. In accordance with modern Russian and international guidelines, this drug should not be used in the treatment of chronic hypoparathyroidism. The main features in the metabolism of dihydrotachysterol (long elimination period, lack of feedback regulation of the active metabolites, high biological activity) and a narrow therapeutic window cause the frequent development of hypercalcemia and associated disorders.
We present several clinical cases of patients with hypoparathyroidism treated with dihydrotachysterol, which was complicated by severe hypercalcemia and acute renal failure.
About the Authors
E. S. AvsievichRussian Federation
Ekaterina S. Avsievich, resident
Moscow
E. V. Kovaleva
Russian Federation
Elena V. Kovaleva, MD
eLibrary SPIN: 7387-6791
11 Dm. Ulyanova street, 117036 Moscow
A. M. Gorbacheva
Russian Federation
Anna M. Gorbacheva, MD
eLibrary SPIN-код: 9815-7509
Moscow
A. K. Eremkina
Russian Federation
Anna K. Eremkina, MD, PhD
Researcher ID: R-8848-2019
Scopus аuthor ID: 57197775339
eLibrary SPIN: 884a8-2660
Moscow
N. G. Mokrysheva
Russian Federation
Natalia G. Mokrysheva, MD, PhD, Professor
eLibrary SPIN: 5624-3875
Moscow
Competing Interests:
Мокрышева Н.Г. — член редакционной коллегии журнала «Ожирение и метаболизм».
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1. Рис. 1. Динамика изменения кальциемии у пациентки А. в зависимости от получаемой терапии. | |
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For citations:
Avsievich E.S., Kovaleva E.V., Gorbacheva A.M., Eremkina A.K., Mokrysheva N.G. Dihydrotachysterol: a bad choice in the treatment of chronic hypoparathyroidism. Obesity and metabolism. 2022;19(2):198-205. (In Russ.) https://doi.org/10.14341/omet12882

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