Obesity and covid-19 — signs of convergence of two pandemiсs. Guidelines to fight obesity based on the principles of «ROOTS»
https://doi.org/10.14341/omet12745
Abstract
The COVID-19 pandemic is a challenging problem of the present. Another essential problem causing serious health consequences is the global obesity epidemy. Our article notes the importance of studying the combinations and correlations of mentioned pandemic processes. We analyzed scientific reports of co-presence of obesity, diabetes and coronavirus infection. According to the analyzed data combination of COVID-19 with obesity and diabetes leads to the higher rate of the hospitalisation. These patients more often required the transfer to the intensive care unit and artificial lung ventilation. Our review contains scientific observations of the first reported cases of higher mortality rate of obese and diabetic patients during the period of previous influenza pandemics (including H1N1). The results of the 2020 year shows that the outcomes of coronavirus infection with underlying obesity much more threatening and harmfull. In our article, we present the correlation of the average body mass and mortality rate index in different countries (according to the WHO and the World Obesity Federation). Comparative results in the Central Asia countries are given as well. The paper analyzes the suggestions for obesity policy and advocacy provided by World Obesity Federation in “ROOTS: A framework for action”. The conclusions marks the importance of implementing the proposed measures against obesity during a pandemic and in the post-COVID era.
About the Authors
A. B. Fursov
Astana medical university
Kazakhstan
Competing Interests:
Kazakhstan
Alexandr B. Fursov - MD, PhD, Professor; Researcher ID: AAM-9615-2021; Scopus Author ID: 6603714989; eLibrary SPIN-код: 6393-8283
25-G, Bokeihana street, 010000, Nur-Sultan
Competing Interests:
none
O. B. Ospanov
Astana medical university
Kazakhstan
Competing Interests:
Kazakhstan
Oral B. Ospanov - MD, PhD, Professor; Researcher ID: J-8795-2012; Scopus Author ID:6505950417; eLibrary SPIN: 9940-6026
Nur-Sultan
Competing Interests:
none
R. A. Fursov
Astana medical university
Kazakhstan
Competing Interests:
Kazakhstan
Roman A. Fursov - MD, PhD; Researcher ID: N-7939-2014; Scopus Author ID: 57190808131; eLibrary SPIN-код: 6331-5975.
Nur-Sultan
Competing Interests:
none
References
1. WHO. Controlling the global obesity epidemic. 2021. Available from: https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight [cited April 27, 2021].
2. Kumanyika S, Dietz WH. Solving Population-wide Obesity — Progress and Future Prospects. N Engl J Med. 2020;383(23):2197-2200. doi: https://doi.org/10.1056/NEJMp2029646
3. Berry EM. The Obesity Pandemic — Whose Responsibility? No Blame, No Shame, Not More of the Same. Frontiers in Nutrition. 2020;7:2. doi: https://doi.org/10.3389/fnut.2020.00002
4. Fursov RA, Ospanov OB, Fursov AB. Obesity as an actual problem: Spatial research in Kazakhstan (2011–2016). Indian Journal of Public Health Research and Development. 2018;9(7):1-7. doi: https://doi.org/10.5958/0976-5506.2018.00603.4
5. Imashev MS, Fursov AB, Imasheva BS, et al. Gastroduodenal Bleeding and Perforation in Diabetic Patients pith Metabolic Syndrome (The Results of a 15-Year Observation of City Residents with Intensive Urbanization). Iranian Journal of Public Health; 2019;48(10):1786-1793.
6. Yadav R, Aggarwal S, Singh A. SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity. Diabetes Metab Syndr Clin Res Rev. 2020;14(5):1355-1360. doi: https://doi.org/10.1016/j.dsx.2020.07.030
7. Moser JAS, Galindo-Fraga A, Ortiz-Hernández AA. Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from infuenza and other respiratory viruses. Influenza and Other Respiratory Viruses. 2019;13:3-9. doi: https://doi.org/10.1111/irv.12618
8. Louie JK, Acosta M, Winter K. Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California. Journal of the American Medical Association. 2009;302:1896-1902. doi: https://doi.org/10.1001/jama.2009.1583
9. Akinnusi ME, Pineda LA, El Solh AA. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Critical Care Medicine. 2008;36(1):151-158. doi: https://doi.org/10.1097/01.CCM.0000297885.60037.6E
10. Morgan OW, Bramley A, Fowlkes A, et al. Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease. PLoS One. 2010;5(3):e9694. doi: https://doi.org/10.1371/journal.pone.0009694
11. Jain S, Chaves SS. Obesity and Influenza. Clinical Infectious Diseases. 2011;53(5):422-424. doi: https://doi.org/10.1093/cid/cir448
12. Kwong JC, Campitelli MA, Rosella LC. Obesity and Respiratory Hospitalizations During Influenza Seasons in Ontario, Canada: A Cohort Study. Clin Infect Dis. 2011;53(5):413-421. doi: https://doi.org/10.1093/cid/cir442
13. Ametov AS, Demidova TYu,. Stelmakh MB, Depyui TI. The relationship of obesity and type 2 diabetes, in the light of evidence-based medicine. Endocrinologiya. 2016;2(15):38-50. (In Russ.).
14. Martinez L. Risk of influenza in people with diabetes. European Scientific Working group on Influenza (ESWI). Influenza Diabetes Community. Satellite symposium: 55th EASD Annual Meeting: Barcelona; 2019. P. 7-10. Available from: https://eswi.org/influenza-diabetes-community/wp-content/uploads/sites/17/2020/01/ESWI_EASD_180919_Barcelona.pdf [cited April 27, 2021].
15. Smith SA, Poland GA. Use of influenza and pneumococcal vaccines in people with diabetes. Diabetes Care. 2000;23(1):95-108. doi: https://doi.org/10.2337/diacare.23.1.95
16. Karlsson EA, Milner JJ, Green WD, et al. Influence of obesity on the response to influenza infection and vaccination. In: Mechanisms and Manifestations of Obesity in Lung Disease. Vol 23. Elsevier; 2019:227-259. doi: https://doi.org/10.1016/B978-0-12-813553-2.00010-5
17. Atkinson RL, Dhurandhar NV, Allison DB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. International Journal of Obesity. 2005;29(3):281-286. doi: https://doi.org/10.1038/sj.ijo.0802830
18. Wigand R, Gelderblom H, Wadell G. New human adenovirus (candidate adenovirus 36), a novel member of subgroup D. Archives of Virology. 1980;64:225-233. doi: https://doi.org/10.1007/BF01322702
19. Barrera-Alcocer J, García-Benavides L, Muñoz-Valle JF, et al. Presence of Adenovirus-36 DNA in Adipose Tissue of Women: Relationship with Adipocyte Morphology and the Expression of C/EBPβ and HIF-1α. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2021;14:477-486. doi: https://doi.org/10.2147/DMSO.S285341
20. Shvarts VI. Inflammation of the adipose tissue (Part 4). Obesity: a new infectious disease? (a literature review). Problems of Endocrinology. 2011;57(5):63-71. (In Russ.). doi: https://doi.org/10.14341/probl201157563-71
21. Mitra AK, Clarke K. Viral obesity: fact or fiction? Obesity Reviews. 2011;11(4):289-296. doi: https://doi.org/10.1111/j.1467-789X.2009.00677.x
22. Honce R, Schultz-Cherry S. Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution. Front Immunol. 2019;10. doi: https://doi.org/10.3389/fimmu.2019.01071
23. Wise J. Covid-19: Highest death rates seen in countries with most overweight populations. The BMJ. 2021;372:n623. doi: https://doi.org/10.1136/bmj.n623
24. COVID-19 and Obesity: The 2021 Atlas, World Obesity Federation. London; 2021. 226 p. Available from: https://www.worldobesityday.org/assets/downloads/COVID-19-and-Obesity-The-2021-Atlas.pdf
25. WHO. Weekly epidemiological update on COVID-19 — 30 March 2021. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---31-march-2021 [cited April 27, 2021].
26. WHO. Global Health Observatory data repository. Prevalence of overweight among adults, BMI ≥25, age-standardized. Available from: https://apps.who.int/gho/data/view.main.CTRY2430A [cited April 27, 2021].
27. Popkin BM, Du S, Green WD, et al. Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships. Obesity Reviews. 2020;21(11):e13128. doi: https://doi.org/10.1111/obr.13128
28. Reilev M, Kristensen KB, Pottegård A, et.al. Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort. International Journal of Epidemiology. 2020;49(5):1468-1481. doi: https://doi.org/10.1093/ije/dyaa140
29. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention. Journal of the American Medical Association. 2020;323:1239-1242. doi: https://doi.org/10.1001/jama.2020.2648
30. Peng Y.D., Meng K., Guan H.Q. Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV. Zhonghua Xin Xue Guan Bing Za Zhi [Chinese journal of cardiovascular diseases]. 2020;24;48(6):450-455. [In Chinese]. doi: 10.3760/cma.j.cn112148-20200220-00105
31. Zheng KI, Gao F, Wang XB. Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease. Metabolism. 2020;108:154244. doi: https://doi.org/10.1016/j.metabol.2020.154244
32. Cai Q, Fengjuan C, Fang L, et al. Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China. Diabetes Care. 2020;43(7):1392-1398. doi: https://doi.org/10.2139/ssrn.3556658
33. Wargny M, Potier L, Gourdy P, et al. Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study. Diabetologia. 2021;64:778-794. doi: https://doi.org/10.1007/s00125-020-05351-w
34. Favre G, Legueult K, Pradier C, et al. Visceral fat is associated to the severity of COVID-19. Metabolism. 2021;115:154440. doi: https://doi.org/10.1016/j.metabol.2020.154440
35. Home-Johns Hopkins Coronavirus Resource Center (jhu.edu). Available from: https://coronavirus.jhu.edu. [cited April 27, 2021].
36. IMF. International Monetary Fund. Word Economic Outlook Reports. Available from: https://www.imf.org/en/Search#q=WORLD%20ECONOMIC%20OUTLOOK%20REPORTS&sort=relevancy [cited April 27, 2021].
37. The Ljubljana Statement on Health Equity. Accelerating Progress Towards Healthy and Prosperous Lives for All in the WHO European Region High-level Conference (13.06.2019). Ljubljana, Slovenia; 2019. Available from: https://www.euro.who.int/ru/publications/policy-documents/ljubljana-statement-on-health-equity-2019 [cited April 27, 2021].
38. Statement — Update on COVID-19: WHO/Europe calls for action on post-COVID conditions/“long COVID” (by Dr Hans Henri P. Kluge, WHO Regional Director for Europe 25 February 2021) Available from: https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/statements/statement-update-on-covid-19-whoeurope-calls-for-action-on-post-covid-conditionslong-covid [cited April 27, 2021].
39. The Lancet. 2019: the year for nutrition. Lancet. 2019;393(10168):200. doi: https://doi.org/10.1016/S0140-6736(19)30080-7
40. Ospanov OB, Yeleuov GA, Bekmurzinova FK. Gastric bypass in modern bariatric surgery. Obesity and metabolism. 2020;17(2):130-137. (In Russ.). doi: https://doi.org/10.14341/omet10161
41. Willett W, Rockström J, Loken B, et al. Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems. The Lancet. 2019;393(10170):447-492. doi: https://doi.org/10.1016/S0140-6736(18)31788-4
42. Tedros Adhanom Ghebreyesus. WHO Director-General’s opening remarks at Obesity — Setting the Global agenda event — 4 March 2021. WHO — 2021. Available from: https://www.who.int/ru/director-general/speeches/detail/who-director-general-s-opening-remarks-at-obesity-setting-the-global-agenda-event-4-march-2021 [cited April 27, 2021].
Supplementary files
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1. Figure 1. COVID-19 mortality per 100,000 population. * *Source of statistics: WHO; Johns Hopkins University of Medicine Coronavirus Resource Center (01.01.2021) [25]. | |
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2. Figure 2. Prevalence of overweight (>25 kg/m2) in adults. Percentage of overweight residents, %. * *Source of statistics: WHO; Johns Hopkins University of Medicine Coronavirus Resource Center (01.01.2021) [25]. | |
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3. Figure 3. COVID-19 mortality (R1) correlation with overweight (R1–2), obesity (R1–3), age (R1–4), GDP per capita (R1–5), life expectancy (R1-6), insufficient physical activity (R1-7). | |
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Review
For citations:
Fursov A.B., Ospanov O.B., Fursov R.A. Obesity and covid-19 — signs of convergence of two pandemiсs. Guidelines to fight obesity based on the principles of «ROOTS». Obesity and metabolism. 2021;18(4):456-464. (In Russ.) https://doi.org/10.14341/omet12745
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