Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide
https://doi.org/10.14341/omet12734
Abstract
Background: Considering the influence of visceral obesity on male infertility, the investigation of ejaculate quality indicators under obesity treatment is relevant.
Objective: Evaluation of ejaculate quality indicators by obesity treatment with liraglutide in andrologically healthy men with infertility and post-pubertal visceral obesity.
Methods: Infertile men with post-pubertal alimentary visceral obesity were included in a pilot observational prospective study. All patients were given recommendations for body weight loss (hypocaloric diet, daily aerobic physical activity) as well as an average daily dose of liraglutide 2.4 [2.4; 3.0] mg. Evaluation of waist circumference, antioxidant activity of ejaculate, spermogram was carried out initially and after 6 months. The differences were considered statistically significant at p <0.005.
Results: The body weight decrease was -11.7 [12.4; 11.0]%, the waist circumference decrease was 8 [12; 7] cm. In dynamics, increased content of living sperm in ejaculate from 92 [90; 95]% to 95 [92; 98]%, morphologically normal forms from 5 [3; 6]% to 6 [3; 8]%, mobility of A + B from 25 [15; 36] to 35 [19; 52]%, seminal antioxidant capacity, a decrease in reactive oxygen forms in the neat ejaculate were statistically significant. Increasing the sperm count in 1 ml and decreasing reactive oxygen forms in the washed ejaculate did not reach statistical significance.
Conclusion: Ejaculate quality indicators improved by the complex obesity therapy with liraglutide in young andrologically healthy men with postpubertal visceral obesity.
About the Authors
D. N. Bobkov
Endocrinology Research Centre
Russian Federation
Russian Federation
Daniil N. Bobkov, MD
11 Dm. Ulyanova street, 117036 Moscow, Russia
R. V. Rozhivanov
Endocrinology Research Centre
Russian Federation
Russian Federation
Roman V. Rozhivanov, MD, PhD
Moscow
I. I. Vityazeva
Endocrinology Research Centre
Russian Federation
Russian Federation
Irina I. Vityazeva, MD, PhD
Moscow
References
1. Rozhivanov RV, Kurbatov DG. The structure of pathozoospermia in young men with post-pubertal visceral obesity and a non-aggravated andrologic anamnesis. Obesity and metabolism. 2017;14(4):32-37. (In Russ.). doi: https://doi.org/10.14341/omet2017432-37
2. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online. 2015;31(5):593-604. doi: https://doi.org/10.1016/j.rbmo.2015.07.012
3. Faure C, Dupont C, Baraibar MA, et al. In Subfertile Couple, Abdominal Fat Loss in Men Is Associated with Improvement of Sperm Quality and Pregnancy: A Case-Series. PLoS One. 2014;9(2):e86300. doi: https://doi.org/10.1371/journal.pone.0086300
4. Dedov II, Mel’nichenko GA, Shestakova MV., et al. Russian national clinical recommendations for morbid obesity treatment in adults. 3rd revision (Morbid obesity treatment in adults). Obesity and metabolism. 2018;15(1):53-70. (In Russ.). doi: https://doi.org/10.14341/omet2018153-70
5. Silva PV, Borges C dos S, Rosa J de L, et al. Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats. J Appl Toxicol. 2020;40(7):947-964. doi: https://doi.org/10.1002/jat.3955
6. Rossijskaya associaciya endokrinologov. Klinicheskie rekomendacii «Lechenie ozhireniya u vzroslyh». 2019. Available from: https://www.endocrincentr.ru/sites/default/files/specialists/science/clinic-recomendations/kr_ozhirenie_13_maya_2019-dlya_rassylki.pdf (In Russ.).
7. WHO. 2010 — WHO laboratory manual for the Examination and processing of human semen. Fifth edition, 2012.
8. Gerasimova EL. Potenciometriya v issledovanii antioksidantnoj aktivnosti biologicheskih obyektov. [dissertation]. Kazan; 2010. (In Russ.).
9. Håkonsen LB, Thulstrup AM, Aggerholm AS, et al. Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men. Reprod Health. 2011;8(1):24. doi: https://doi.org/10.1186/1742-4755-8-24
10. Mir J, Franken D, Andrabi SW, et al. Impact of weight loss on sperm DNA integrity in obese men. Andrologia. 2018;50(4):e12957. doi: https://doi.org/10.1111/and.12957
11. El Bardisi H, Majzoub A, Arafa M, et al. Effect of bariatric surgery on semen parameters and sex hormone concentrations: a prospective study. Reprod Biomed Online. 2016;33(5):606-611. doi: https://doi.org/10.1016/j.rbmo.2016.08.008
12. Gutiérrez L, García JR, Rincón M de J, et al. Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants. Med Clínica (English Ed. 2015;145(1):1-6. doi: https://doi.org/10.1016/j.medcle.2015.12.043
13. Bobkov DN, Rozhivanov RV, Savelyeva LV. Semen quality indicators associated with reduced body weight in young infertile men with pathozoospermia, postpubertal visceral obesity and normal andrological history. Obesity and metabolism. 2020;17(4):340-345. (In Russ.). doi: https://doi.org/10.14341/omet12679
14. Izzi-Engbeaya C, Jones S, Crustna Y, et al. Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men. J Clin Endocrinol Metab. 2020;105(4):1119-1125. doi: https://doi.org/10.1210/clinem/dgaa072
15. Jensterle M, Podbregar A, Goricar K, et al. Effects of liraglutide on obesity-associated functional hypogonadism in men. Endocr Connect. 2019;8(3):195-202. doi: https://doi.org/10.1530/EC-18-0514
16. Gamidov SI, Shatylko TV, Gasanov NG. Male health and obesity — diagnostic and therapeutic approach. Obesity and metabolism. 2019;16(3):29-36. (In Russ.). doi: https://doi.org/10.14341/omet10314
17. Salas-Huetos A, Muralidharan J, Galiè S, et al. Effect of Nut Consumption on Erectile and Sexual Function in Healthy Males: A Secondary Outcome Analysis of the FERTINUTS Randomized Controlled Trial. Nutrients. 2019;11(6):1372. doi: https://doi.org/10.3390/nu11061372
18. Pereira SC, Crisóstomo L, Sousa M, et al. Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health. Environ Epigenetics. 2020;6(1):1372. doi: https://doi.org/10.1093/eep/dvaa019
19. Giulini S, Sblendorio V, Xella S, et al. Seminal plasma total antioxidant capacity and semen parameters in patients with varicocele. Reprod Biomed Online. 2009;18(5):617-621. doi: https://doi.org/10.1016/S1472-6483(10)60004-1
20. Roychoudhury S, Sharma R, Sikka S, Agarwal A. Diagnostic application of total antioxidant capacity in seminal plasma to assess oxidative stress in male factor infertility. J Assist Reprod Genet. 2016;33(5):627-635. doi: https://doi.org/10.1007/s10815-016-0677-5
21. Subramanian V, Ravichandran A, Thiagarajan N, et al. Seminal reactive oxygen species and total antioxidant capacity: Correlations with sperm parameters and impact on male infertility. Clin Exp Reprod Med. 2018;45(2):88-93. doi: https://doi.org/10.5653/cerm.2018.45.2.88
22. Venkatesh S, Shamsi MB, Dudeja S, et al. Reactive oxygen species measurement in neat and washed semen: comparative analysis and its significance in male infertility assessment. Arch Gynecol Obstet. 2011;283(1):121-126. doi: https://doi.org/10.1007/s00404-010-1645-4
23. Moein MR, Vahidi S, Ghasemzadeh J, Tabibnejad N. Comparison of reactive oxygen species in neat and washed semen of infertile men. Iran J Reprod Med. 2014;12(5):301-306.
24. Grossmann M. Hypogonadism and male obesity: Focus on unresolved questions. Clin Endocrinol (Oxf). 2018;89(1):11-21. doi: https://doi.org/10.1111/cen.13723
Supplementary files
Review
For citations:
Bobkov D.N., Rozhivanov R.V., Vityazeva I.I. Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide. Obesity and metabolism. 2021;18(3):263-267. (In Russ.) https://doi.org/10.14341/omet12734
Views:
1230
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
