To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D
https://doi.org/10.14341/omet12578
Abstract
The influence of obesity on human health, as a multifactorial and multigenic disorder, is a rather complex, interdisciplinary and at the same time extremely urgent problem of modern society. Vitamin D deficiency is one of the consequences of obesity that negatively affects a person’s life expectancy. Vitamin D deficiency is rightfully considered a silent, non-infectious metabolic pandemic of the 21st century. Its significant role in the functioning of the human body is deep and multifaceted, since vitamin D is an integral regulator of the transcriptional activity of genes that control 3–5% of the human genome. There are ongoing discussions among experts in the medical community about the negative impact of obesity on 25 (OH) D levels, and the opposite hypothesis is also being discussed, where vitamin D deficiency is considered an independent risk factor for obesity. Both external causes of the formation of vitamin D deficiency against the background of excessive deposition of adipose tissue and internal metabolic processes underlying the pathogenetic association are analyzed two pathological conditions.
About the Authors
L. A. Suplotova
Tyumen State Medical University
Russian Federation
Competing Interests:
Russian Federation
Liudmila A. Suplotova, MD, PhD, Professor; eLibrary SPIN: 1212-5397
Competing Interests:
not
V. A. Avdeeva
Tyumen State Medical University
Russian Federation
Competing Interests:
Russian Federation
Valeria A. Avdeeva, MD; eLibrary SPIN: 3215-0880.
54 Odesskaya street, 625023 Tyumen
Competing Interests:
not
L. Y. Rozhinskaya
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Liudmila Y. Rozhinskaya, MD, PhD, Professor; eLibrary SPIN: 5691-7775
Competing Interests:
not
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Suplotova L.A., Avdeeva V.A., Rozhinskaya L.Y. To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D. Obesity and metabolism. 2021;18(2):169-174. (In Russ.) https://doi.org/10.14341/omet12578
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