The relationship of vitamin D status with the development and course of diabetes mellitus type 1
https://doi.org/10.14341/omet12206
Abstract
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that develops as a result of a genetic predisposition and environmental factors. Literature data indicate that the suboptimal status of vitamin D can be considered as a risk factor for the development of T1DM, especially at some stages of life. Adequate vitamin D supplementation in childhood may provide a protective effect and reduce the risk of developing T1DM at a later age. Pathogenesis of T1DM predisposes to abnormalities in the metabolism of vitamin D, including the development of vitamin D deficiency. Moreover, the immunomodulating effect of calcitriol (induction of immune tolerance and T-cell anergy, impaired B-cell activity and antibodies production) suggests the therapeutic potential of vitamin D in autoimmune diseases, including T1DM. A number of studies have demonstrated the positive clinical effects of various vitamin D preparations with respect to maintaining residual β-cell function, improving glycemia control in patients with T1DM. Determining the optimal doses of vitamin D for patients with T1DM may contribute to disease control and prevention of complications.
Supporting agencies: Russian Science Foundation (project No. 19-15-00243)
About the Authors
Alexandra A. Povaliaeva
Endocrinology Research Centre
Russian Federation
Russian Federation
M.D.
Ekaterina A. Pigarova
Endocrinology Research Centre
Russian Federation
Russian Federation
MD, PhD
Larisa K. Dzeranova
Endocrinology Research Centre
Russian Federation
Russian Federation
ScD
Liudmila Ya. Rozhinskaya
Endocrinology Research Centre
Russian Federation
Russian Federation
MD, PhD, Professor
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Povaliaeva A.A., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Ya. The relationship of vitamin D status with the development and course of diabetes mellitus type 1. Obesity and metabolism. 2020;17(1):82-87. (In Russ.) https://doi.org/10.14341/omet12206
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