Modern concepts of the pathogenesis of obesity and new approaches to its correction
Oksana V. Logvinova,
Alexandra G. Poydasheva,
Ilya S. Bakulin,
Olga V. Lagoda,
Elena I. Kremneva,
Ekaterina A. Troshina,
Natalya V. Mazurina,
Natalia A. Suponeva,
Marine M. Tanashyan,
Ivan I. Dedov,
Michael A. Piradov 
Abstract
The present review considers modern concepts of the physiological mechanisms of the formation of food behavior in a norm at several levels, beginning with the cellular level and ending with the level of functional systems. Neuroimaging methods used for both the study of the pathophysiological foundations of eating disorders and for determining the target for neurostimulation techniques are described. Methods of non-invasive brain stimulation such as transcranial magnetic stimulation and transcranial electrical stimulation, the mechanisms of their influence and aspects of safety of application are reviewed, the latest data on the results of studies on the use of the above methods in the therapy of obesity are summarized.
About the Authors
Oksana V. LogvinovaEndocrinology Research Centre
Russian Federation
postgraduate student
Alexandra G. Poydasheva
Research Center of Neurology
Russian Federation
junior researcher
Ilya S. Bakulin
Research Center of Neurology
Russian Federation
junior researcher, postgraduate student
Olga V. Lagoda
Research Center of Neurology
Russian Federation
senior researcher, PhD
Elena I. Kremneva
Research Center of Neurology
Russian Federation
researcher, PhD
Ekaterina A. Troshina
Endocrinology Research Centre
Russian Federation
ScD, prof., correspondence fellow of Russian Academy of Sciences, head of the department of therapeutic endocrinology
Natalya V. Mazurina
Endocrinology Research Centre
Russian Federation
leading researcher, PhD
Natalia A. Suponeva
Research Center of Neurology
Russian Federation
ScD, head of Neurorehabilitation and Physiotherapy Department
Marine M. Tanashyan
Research Center of Neurology
Russian Federation
ScD, prof., Deputy Director for Research, Head of the First Neurological Department
Ivan I. Dedov
Endocrinology Research Centre
Russian Federation
ScD, prof., academician of Russian Academy of Sciences, Director of Endocrinology Research Center
Michael A. Piradov
Research Center of Neurology
Russian Federation
ScD, prof., academician of Russian Academy of Sciences, Director of Research Centre of Neurology
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2. Fig. 1. Activation zones for a group of healthy volunteers (group analysis) in the implementation of a paradigm superimposed on a three-dimensional image of the brain (above) and sections in the axial projection (below). PP - right hemisphere of the brain, LP - left hemisphere. Green is indicated by DLPPK (9 and 46 PB), yellow - the upper parietal lobe (7 PB), blue - the lower parietal lobe (40 PB). T> 6.32, pFWEcorr <0.05. | |
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Logvinova O.V., Poydasheva A.G., Bakulin I.S., Lagoda O.V., Kremneva E.I., Troshina E.A., Mazurina N.V., Suponeva N.A., Tanashyan M.M., Dedov I.I., Piradov M.A. Modern concepts of the pathogenesis of obesity and new approaches to its correction. Obesity and metabolism. 2018;15(2):11-16. (In Russ.)
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