Functional activity of intestinal microbiota with metabolic syndrome
Abstract
Actuality: The metabolic syndrome (MS) is a multifactorial disease involved in the pathogenesis of many systems and organs, including the digestive system. Accumulating evidence signify the role of microorganisms in many metabolic processes and suggest human microbiota involvement in the development of different pathologic conditions, including the MS.
The aim: To evaluate the qualitative and quantitative characteristics of the functional activity of intestinal microbiota in individuals with MS.
Materials and methods: The study involved 85 subjects with MS divided into 4 groups according to BMI. Determination of the short chain fatty acids in the feces was carried out by gas-liquid chromatographic studies.
Results: Chromatographic examination of feces revealed changes in both qualitative and quantitative characteristics of the functional activity of the intestinal microbiota in people with MS. The severity of disturbances in microbiota correlated with BMI. In all groups with excess body weight the overall metabolic activity of microorganisms was decreased. In grade 2 obesity there was an increases in the activity of aerobic microorganisms populations, mostly of optional and residual strains. The grade 3 obesity is accompanied by the most significant changes in coprologic profile with the activation of proteolytic microorganisms.
Conclusions: These data suggest the presence of pathogenic correlations between obesity, MS, and intestinal microbiota. In this regard, it is necessary to search for causal relationships oin onset and progression of metabolic disorders involving the bowel microbiota in MS..
About the Authors
Al'bert A. Kurmangulov
Tyumen State Medical University
Russian Federation
postgraduate student
Competing Interests: Авторы работы сообщают, что потенциальных и явных конфликтов интересов (финансовые отношения, служба или работа в учреждениях, имеющих финансовый или политический интерес к публикуемым материалам, должностные обязанности и др.), связанные с рукописью, не существуют.
Russian Federation
postgraduate student
Competing Interests: Авторы работы сообщают, что потенциальных и явных конфликтов интересов (финансовые отношения, служба или работа в учреждениях, имеющих финансовый или политический интерес к публикуемым материалам, должностные обязанности и др.), связанные с рукописью, не существуют.
Elena F. Dorodneva
Tyumen State Medical University
Russian Federation
MD, PhD, professor
Russian Federation
MD, PhD, professor
Dilara N. Isakova
Tyumen State Medical University
Russian Federation
PhD, assistant
Russian Federation
PhD, assistant
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For citations:
Kurmangulov A.A., Dorodneva E.F., Isakova D.N. Functional activity of intestinal microbiota with metabolic syndrome. Obesity and metabolism. 2016;13(1):16-19. (In Russ.)
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