Pathogenetic factors of disorders in spermatogenesis and antioxidative activity of an ejaculate in young men with post pubertal visceral obesity and normal andrological anamnesis
Abstract
BACKGROUND: Considering the negative influence of a visceral obesity on spermatogenesis, it is important to investigate its pathogenetic factors.
AIMS: To reveal the pathogenetic factors of disorders in spermatogenesis and antioxidative activity of an ejaculate in young men with post pubertal visceral obesity and normal andrological anamnesis.
MATERIALS AND METHODS: 47 men under 30 years with post pubertal and nutritional visceral obesity have been included into one-stage research. The length of circle of waist, lipid blood spectrum, blood levels of glucose and insulin, antioxidant activity and electronic-microscopic analysis of an ejaculate have been examined. Differences were considered statistically significant with p <0,05.
RESULTS: The LDL and triglyceride levels in patients with disorders in spermatogenesis were significantly higher than considered in men with normozoospermia. Correlations between antioxidative activity of ejaculate and levels of LDL (n=47, r=-0,310; p=0,033), triglyceride (n=47, r=-0,366; p=0,011) and the number of normal spermatozoons in ejaculate (n=47, r=0,343;p=0,017) have been revealed.
CONCLUSIONS: The dyslipidemia in young men with post pubertal visceral obesity and normal andrological anamnesis can be considered as pathogenetic factors of disorders in spermatogenesis. Nevertheless the dyslipidemia can influence spermatogenesis through oxidative stress.
Supporting agencies: The study was carried out as part of a state assignment - “Signal adipocyte molecules: genomic and postgenomic mechanisms for the implementation of the physiological and pathogenetic functions of adipose tissue in endocrinopathies” State registration number R&D AAAA-A17-117012610112.
About the Authors
Roman V. Rozhivanov
Endocrinology Research Centre
Russian Federation
Russian Federation
ScD, head research associate department of Andrology and urology
Daniil N. Bobkov
Endocrinology Research Centre
Russian Federation
Russian Federation
MD, postgraduate student
Dmitriy G. Kurbatov
Endocrinology Research Centre
Russian Federation
Russian Federation
ScD, professor, head of department of Andrology and urology
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Rozhivanov R.V., Bobkov D.N., Kurbatov D.G. Pathogenetic factors of disorders in spermatogenesis and antioxidative activity of an ejaculate in young men with post pubertal visceral obesity and normal andrological anamnesis. Obesity and metabolism. 2019;16(3):76-80. (In Russ.)
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