The effect of type 2 diabetes and its drug therapy on bone quality.
https://doi.org/10.14341/omet2015341-45
Abstract
Individuals with type 2 diabetes have increased risk of fragility fractures. It’s not completely clear by which mechanism type 2 diabetes increases skeletal fragility. A combination of factors, including an increased risk of falling (contributed by complications of the disease) and impaired bone quality apparently leads to a greater fracture risk. Some cl asses of drug therapy for type 2 diabetes may also increase fracture risk by their own mechanism of action.
About the Authors
Tat'yana Olegovna YalochkinaRussian Federation
PhD student
Ekaterina Aleksandrovna Pigarova
Russian Federation
PhD, leading researcher at the Department of Neuroendocrinology and osteopathy
References
1. Achemlal L, Tellal S, Rkiouak F, Nouijai A, Bezza A, Derouiche EM, et al. Bone metabolism in male patients with type 2 diabetes. Clinical Rheumatology. 2005;24(5):493-6. doi:10.1007/s10067-004-1070-9
2. Bollag RJ. Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors. Endocrinology. 2000;141(3):1228-35.doi:10.1210/en.141.3.1228
3. Cortizo AM, Sedlinsky C, McCarthy AD, Blanco A, Schurman L. Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture. European Journal of Pharmacology. 2006;536(1-2):38-46. doi:10.1016/j.ejphar.2006.02.030
4. Gennari L, Merlotti D, Valenti R, Ceccarelli E, Ruvio M, Pietrini MG, et al. Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism. 2012;97(5):1737-44. doi:10.1210/jc.2011-2958
5. List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes. Diabetes Care. 2008;32(4):650-7. doi:10.2337/dc08-1863
6. Gilbert MP, Pratley RE. The Impact of Diabetes and Diabetes Medications on Bone Health. Endocrine Reviews. 2015;36(2):194-213. doi:10.1210/er.2012-1042
7. Monami M, Dicembrini I, Antenore A, Mannucci E. Dipeptidyl Peptidase-4 Inhibitors and Bone Fractures: A meta-analysis of randomized clinical trials. Diabetes Care. 2011;34(11):2474-6. doi:10.2337/dc11-1099
8. Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, et al. Older Women with Diabetes Have an Increased Risk of Fracture: A Prospective Study. The Journal of Clinical Endocrinology & Metabolism. 2001;86(1):32-8. doi:10.1210/jcem.86.1.7139
9. Suzuki K, Kurose T, Takizawa M, Maruyama M, Ushikawa K, Kikuyama M, et al. Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density. Diabetes Research and Clinical Practice. 2005;68(2):117-25. doi:10.1016/j.diabres.2004.08.006
10. Verhaeghe J, Visser WJ, Einhorn TA, Bouillon R. Osteoporosis and Diabetes: Lessons from the Diabetic BB Rat. Hormone Research. 1990;34(5-6):245-8. doi:10.1159/000181834 11. Yamamoto M, Yamauchi M, Sugimoto T. Elevated Sclerostin Levels Are Associated With Vertebral Fractures in Patients With Type 2 Diabetes Mellitus. The Journal of Clinical Endocrinology & Metabolism. 2013;98(10):4030-7. doi:10.1210/jc.2013-2143
11. Zhen D, Chen Y, Tang X. Metformin reverses the deleterious effects of high glucose on osteoblast function. Journal of Diabetes and its Complications. 2010;24(5):334-44. doi:10.1016/j.jdiacomp.2009.05.002
Review
For citations:
Yalochkina T.O., Pigarova E.A. The effect of type 2 diabetes and its drug therapy on bone quality. Obesity and metabolism. 2015;12(3):41-45. (In Russ.) https://doi.org/10.14341/omet2015341-45

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).