Silent pituitary adenomas: review and clinical cases
https://doi.org/10.14341/omet2015239-46
Abstract
Silent, or clinically nonfunctioning adenomas are morphologically heterogeneous group, characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression. Although in some occasions enhanced or changed secretory activity can develop over time. According to immunoreactivity they are divided into "silent" gonado-, cortico-, somato -, mammo – and thyrotropinomas, oncocytomas, «zero-cell» tumors. All types of "silent" adenomas have different biological activity, secretory capacity and outcomes in the postoperative period. This series of clinical cases shows more «aggressiveness», a higher risk of relapse for "silent" cortico- and somatotropinomas. Immunohistochemical analysis of residual tissue can be used to identify patients with high risk of recurrence, to develop optimal treatment and follow-up.
About the Authors
Anna Konstantinovna Lipatenkova
Endocrinology Research Centre
Russian Federation
PhD student
Russian Federation
PhD student
Larisa Konstantinovna Dzeranova
Endocrinology Research Centre
Russian Federation
MD, PhD, leading researcher at the Department of Neuroendocrinology and ostepaty
Russian Federation
MD, PhD, leading researcher at the Department of Neuroendocrinology and ostepaty
Ekaterina Aleksandrovna Pigarova
Endocrinology Research Centre
Russian Federation
Ph.D., senior researcher at the Department of Neuroendocrinology and ostepaty
Russian Federation
Ph.D., senior researcher at the Department of Neuroendocrinology and ostepaty
Ludmila Igorevna Astaf'eva
Burdenko Neurosurgery Institute
Russian Federation
MD, PhD, a physicianat the 8th Neurosurgery department
Russian Federation
MD, PhD, a physicianat the 8th Neurosurgery department
Andrey Yur'evich Grigor'ev
Endocrinology Research Centre
Russian Federation
MD, PhD, head of the Neurosurgery department
Russian Federation
MD, PhD, head of the Neurosurgery department
Ludmila Valentinovna Shishkina
Burdenko Neurosurgery Institute
Russian Federation
PhD, Head of the Neyropatomorfologii department
Russian Federation
PhD, Head of the Neyropatomorfologii department
Vladislav Yur'evich Cherebilo
Almazov federal heart blood and endocrinology centre
Russian Federation
neurosurgeon at the Department of Neurosurgery
Russian Federation
neurosurgeon at the Department of Neurosurgery
Anastasiya Pavlovna Ektova
Russian Pediatric Clinical Hospital
Russian Federation
physicianat the Pathomorphology department
Russian Federation
physicianat the Pathomorphology department
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Review
For citations:
Lipatenkova A.K., Dzeranova L.K., Pigarova E.A., Astaf'eva L.I., Grigor'ev A.Yu., Shishkina L.V., Cherebilo V.Yu., Ektova A.P. Silent pituitary adenomas: review and clinical cases. Obesity and metabolism. 2015;12(2):40-46. (In Russ.) https://doi.org/10.14341/omet2015239-46
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