Relationship of obesity with the main reproductive parameters in men-residents of Novosibirsk (Russia)
https://doi.org/10.14341/2071-8713-5127
Abstract
A link between obesity, overweight and reproductive performance in male volunteers 18 to 40 years (n=261), living in the city of Novosibirsk was investigated. Hormone levels (follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), oestradiol (E2), inhibin B) and main indicators of semen quality (concentration, percentage of motile and morphologically normal sperm) were evaluated in each patient. Following groups were retrospectively formed: the control (group 1, a BMI of 18.5 to 24.9 kg/m2, n=50), overweight men (group 2, a BMI of 25.0 to 29.9 kg/m2, n=28), obese men (group 3, a BMI greater than 30.0 kg/m2, n=5). The exclusion criteria from the analysis were as follows: andrological disease (prostatitis, epididymal cyst, varicocele, sexually transmitted infection), transferred surgery of andrological diseases. A reduction in the testosterone serum concentration was found along the groups in the direction 1->2->3 respectively, 23.3->15.7->11.8 nmol/L (р1,2=0.006; р1,3=0.0001). Semen volume was statistically reduced in obese men compared with normal weight men (p1,3=0.019). There were no significant differences in age, FSH, LH, E2, Inhibin B levels, concentration, motility, percentage of morphologically normal sperm between groups. The findings show the distinct hypoandrogenia in young men with overweight and obesity. A testosterone deficiency is increased with increasing BMI and the testosterone concentration descends to less than 12 nmol/L in the obesity group, which corresponds to hypogonadism.
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Relationship of obesity with the main reproductive parameters in men-residents of Novosibirsk (Russia). Obesity and metabolism. 2012;9(4):34-38. (In Russ.) https://doi.org/10.14341/2071-8713-5127
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