The relationship of hormone-metabolic disorders and indicators of anxiety and depression in young men with obesity on different types of therapy

Objective: to assess hormonal and metabolic parameters and psychological status of young men with obesity. Methods: The study included 60 men with obesity (BMI>30 kg/m2) divided in two groups. Patients in the first group (n=30) received orlistat for 12 weeks (120 mg 3 times daily with meal). Patients in second group (n=30) followed hypocaloric diet and aerobic exercise. All patients were examined before treatment and after 12 weeks. Evaluation included hormonal and biochemical analyses, 48 patients were examined by psychological questionnaires (Beck Depression Inventory, Beck Anxiety Inventory, Liebowitz Social Anxiety Scale, Dutch Eating Behavior Questionnaire). Results: Patients that received orlistat treatment showed significant decrease of body mass: 50% of patients had decrease more than 5%, 30% of patients - more than 10% (p<0,05). In first group after 12 weeks of treatment level of cortisol decreased and level of testosterone increased. The results of treatment in second group were less significant. There was a significant decrease in anxiety and depression scales in patients taking orlistat (p<0,05). High levels of social anxiety did not decrease in both groups after treatment. As a result of orlistat treatment there was a decrease in external eating behavior and increase in expression of restraint eating behavior by DEBQ (p<0,05). Conclusions: treatment with orlistat reduces body weight, which is correlated by improvement of hormonal and biochemical parameters. Weight loss is accompanied by changes in rates of anxiety and depression.

obesity, male, orlistat, hormonal and metabolic disorders, depression, social anxiety, eating behavior

1. Вознесенская Т.Г. Расстройства пищевого поведения при ожирении и их коррекция. Международный эндокринологический журнал - 2007. - т.3 (9).

2. Вознесенская Т.Г., Соловьева А.Д., Фокина Н.М. Психоэндокринные взаимоотношения у больных в состоянии эмоционального стресса при церебральном ожирении. Проблемы эндокринологии 1989;35(1):3-7.

3. Кочетков Я.А. Депрессия и гипоталамо-гипофизарно-надпочечниковая система: новые стратегии изучения. Современные проблемы психиатрической эндокринологии. М., 2004: 160-175.

4. Малкина-Пых ИГ. Терапия пищевого поведения. М.: Эксмо, 2007: 1040.

5. Carpenter KM, Hasin DS, Allison DB, Faith MS. Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: results from a general population study. Am. J. Public Health 2000;90(2):251-257.

6. Dixon JB, Dixon ME, O&amp;apos;Brien PE. Depression in association with severe obesity: changes with weight loss. Arch. Intern. Med 2003;163:2058-2065.

7. Dockray S, Susman E, Dorn LD. Depression, Cortisol Reactivity and Obesity in Childhood and Adolescence. J. Adolesccence Health 2009;45(4):344-350.

8. Goodman E, Whitaker RC. A prospective study of the role of depression in the development and persistence of adolescent obesity. Pediatrics 2002;110(3):497-504.

9. Hach I, Ruhl UE, Klotsche J, Klose M, Jacobi F. Associations between waist circumference and depressive disorders. J. Affect. Disord 2006;92(2-3):305-308.

10. Ho R.C., Niti M., Kua E.H., Ng T.P. Body mass index, waist circumference, waist-hip ratio and depressive symptoms in Chinese elderly: a population-based study. Int. J. Geriatr. Psychiatry 2008;23(4):401-408.

11. Jorm AF, Korten AE, Christensen H, Jacomb PA, Rodgers B, Parslow RA. Association of obesity with anxiety, depression and emotional well-being: a community survey. Aust. N. Z. Journal of Public Health 2003;27(4):434-40.

12. Keddie AM. Associations Between Severe Obesity and Depression: Results From the National Health and Nutrition Examination Survey, 2005-2006. Prevention of Chronic Diseases 2011;8(3):57-61.

13. Pine DS, Cohen P, Brook J, Coplan JD. Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study. Am. J. Public Health 1997;87(8):1303-10.

14. Rosmond R. Obesity and depression: same disease, different names? Med. Hypotheses 2004;62(6):976-979.

15. Styne DM. Child food and adolescent obesity. Prevalence and significance. Pediatric Clin North Am 2001;48(4):823-854.

16. Therrien F, Drapeau V, Lalonde J, Lupien SJ. Cortisol response to the Trier Social Stress Test in obese and reduced obese individuals. Biol. Psychology 2010;84(2):325-329.

17. World Health Organization. Global Health Risks: mortality and burden of disease attributable to selected major risk (2009). http://www.who.int/heaithinfo/global_burden_disease/_global_health risks/en/index.html.