Osobennosti metabolizma kostnoy tkanipri sindrome mnozhestvennykh endokrinnykhneoplaziy 1 tipa
https://doi.org/10.14341/2071-8713-4878
Abstract
Bone metabolism and changes in bone mineral density (BMD) are very important in patients with multiple endocrine neoplasia
(MEN) type 1 syndrome. Case report: we present a clinical case of primary hyperparathyroidism (PHPT) in a patient with a familal MEN
1 syndrome and severe PHPT debuted at a young age w. Pituitary Cushing syndrome was diagnosed in 16 years old patient. He had marked
osteoporosis due to hypercorticism and deficiency of sex hormones (-12% from the age norm). There was significant positive dynamics
in BMD (+7% by Z-score) after remission of hypercorticism by two courses of radiation treatment and effective hormone replacement therapy
of hypogonadism. PHPT with marked decrease in BMD at three sites was revealed at age of 19 years. Obvious increase in BMD was observed
during a year after effective surgical treatment and antiosteoporotic therapy. In conclusion, this clinical case demonstrates the combined
influence of various factors on bone metabolism in patients with MEN type 1 syndrome, which requires integrated approach to successful
therapy.
(MEN) type 1 syndrome. Case report: we present a clinical case of primary hyperparathyroidism (PHPT) in a patient with a familal MEN
1 syndrome and severe PHPT debuted at a young age w. Pituitary Cushing syndrome was diagnosed in 16 years old patient. He had marked
osteoporosis due to hypercorticism and deficiency of sex hormones (-12% from the age norm). There was significant positive dynamics
in BMD (+7% by Z-score) after remission of hypercorticism by two courses of radiation treatment and effective hormone replacement therapy
of hypogonadism. PHPT with marked decrease in BMD at three sites was revealed at age of 19 years. Obvious increase in BMD was observed
during a year after effective surgical treatment and antiosteoporotic therapy. In conclusion, this clinical case demonstrates the combined
influence of various factors on bone metabolism in patients with MEN type 1 syndrome, which requires integrated approach to successful
therapy.
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, , , , , Osobennosti metabolizma kostnoy tkanipri sindrome mnozhestvennykh endokrinnykhneoplaziy 1 tipa. Obesity and metabolism. 2009;6(4):42-46. (In Russ.) https://doi.org/10.14341/2071-8713-4878
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