Soderzhanie leptina i pokazateli uglevodnogoobmena u bol'nykh ozhireniem posledieto-refleksoterapii
https://doi.org/10.14341/2071-8713-4876
Abstract
The article describes the results of a combined treatment by means of diet and reflexotherapy in primary obesity. After the described
treatment programme the change in following parameters was observed: decrease of glucose levels, immuno-reactive insulin
indices (on an empty stomach and 2 hours after taking 75g of glucose), leptin (after the course of treatment and a year later) with the association
in decrease in body weight. The application of diet-reflexotherapy contributes to the decrease of appetite which results in the
reduction of the amount of taken food due to rapid satiety during the meal, and allows alleviating of insulin resistance.
treatment programme the change in following parameters was observed: decrease of glucose levels, immuno-reactive insulin
indices (on an empty stomach and 2 hours after taking 75g of glucose), leptin (after the course of treatment and a year later) with the association
in decrease in body weight. The application of diet-reflexotherapy contributes to the decrease of appetite which results in the
reduction of the amount of taken food due to rapid satiety during the meal, and allows alleviating of insulin resistance.
References
1. Мельниченко Г.А. Ожирение: эпидемиология, классификация, патогенез, клиническая симптоматика и диагностика / Г.А. Мельниченко, Т.И. Романцова // Ожирение / под ред. И.И. Дедова, Г.А. Мельниченко. - М.: МИА, 2004. - С. 16-43.
2. Романцова Т.И. Эндоканнабиноидная система: структура и потенциальные возможности в регуляции массы тела / Т.И. Романцова, И.И. Дедов, И.С. Кузнецов // Ожирение и метаболизм. - 2006. - №4. - С. 2-11.
3. Самосюк И.З. Акупунктура: энциклопедия // И.З. Самосюк, В.П. Лысенюк. - Киев; Москва,1994. - 543 с.
4. Bjorbaek C., Kahn В.В. // Recent Prog. Horm. Res. - 2004. - Vol. 59. - P. 305-31.
5. Colombo C. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy / С. Colombo, J.J. Cutson, Т. Yamauchi // Diabetes. -2002. -№51 - Р. 2727-2733.
6. Considine R.V., Considine E.L., Williams С.J. et al. // Diabetes. - 1966. - Vol. 19. - P. 992-4.
7. Ebihara K. Transgenic oven expression ol leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes / K. Ebihara, V. Оgawa, Masuzaki et al. // Diabetes. - 2001. - Vol. 50. - P. 1440-48.
8. Farooqi I.S. Beneficial еffeets of leptin on obesity, T cell hypo responsiveness, and neuroiroendocrine/metabolic dysfunction of human congenital leptin deficiency / I.S. Farooqi, С. Mataresc, G.M. Lord et al. // Clin. Invest. - 2002. -Vol. 110. - Р. 1093 - 103.
9. Flier J.S. // Cell. - 2004. - Vol. 116. - P. 337-50.
10. Franks P.W., Brage S., Luan J. et al. // Obes. Res. - 2005. - Vol. 13. - P. 1476- 84.
11. Ghiiardi N. Defective STAT signaling by the leptin receptor in diabetic mice / N. Ghiiardi, S. Ziegler, A. Wiestner еt al. // Proc. Natl. Acad. Sci. USA. - 1996. - Vol. 93. - P. 6231-5.
12. Heymsfield S.B. Recombinant leptin for weight loss in obese and lcan adults: a randomized, controlled, dose-escalation trial / S.B. Heymsfield, A.S. Grecnbcrg, K. Fujioka еt al. // JAMA. - 1999. - Vol. 282. - P. 1568-75.
13. Kellerer M. Leptin activates PI-3 kinase in C2Q2 myotubes via janus kinase-2 (JAK- 2) and insulin receptor substrate-2 (IRS-2) dependent pathways / М. Kellerer, M. Koch, E. Metzinger еt al. // Diabetologia. - 1997. - Vol. 40. -Р. 1358-62.
14. Mazaki-Tovi S. Adiponectin and leptin concentrations in dichorionic twins with discordant and concordant growth / S. Mazaki-Tovi, H. Kanety, C. Pariente // J. Clin. Endocrinol. Metab. - 2008. - Dec. 9.
15. Motivala S.J. Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia / S.J. Motivala, A.J. Tomivama, М. Zieqler еt al. // Psychoneuroendocrinoloqy. - 2008. - Dec. 5.
16. Muoio D.M. Leptin directly alters -lipid partitioning in skeletal muscle / D.M. Muoio,G.L. Dohm, F.T. Ficdorek et al. / D.M. Muoio, G.L. Dohm, F.T. Ficdorek // Diabetes. - 1997. -Vol. 46. - P. 1360-3.
17. Perseghin G. Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes / G. Perseghin, G. Lattuada, M. Danna et al. // Am. J. Physiol. Endocrinol. Metab. - 2003. - Vol. 285. - Р. E1174-81.
18. Popovic V. Brain somatic cross-talk: ghrelin, leptin and ultimate challengers of obesity / V. Popovic, L.H. Duntas // Nutr Neurosci. -2005. - Feb. - №8. - P. 1-5.
19. Rahmouni K. Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effectsof Leptin / K. Rahmouni, C.D. Sigmund, W.G. Havnes, A.L. Mark // Diabetes. -2008. - Dec. 9.
20. Shimabukuro M. Direct antidiabetic effect of leptin through triglyceride depletion of rissues / M. Shimabukuro, K. Koyama, G. Chen еt al. // Proc. Narl. Acad. Sci. USA. - 1997. - Vol. 94. - P. 4637-41.
21. Shimomura I. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy / I. Shimomura, R.E. Hammer, S. Ikemoto // Nature. - 1999. - Vol. 401. - Р. 73-6.
22. Skibicka K.P. Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors / K.P. Skibicka, Н.J. Grill // Endocrinology. - 2008. - Dec. 4.
23. Sweeney G. Leptin signaling / G. Sweeney // Cell. Signal. -2002. - №14. - Р. 655-63.
24. Unger R.A. // Biochemie. - 2005. - Vol. 87. - P. 5764. 25. Woliiiski 3. Presence of leptin in mammalian colostrum and milk and in artificial milk formulas / З. Woliiiski, R. Zabielski // Med. Wieku. Rozwoj. - 2005. - Oct.- Dec. - Vol. 9, №4. - P. 629-36.
25. Wozniak S.E. Adipose Tissue: The New Endocrine Organ? A Review Article / S.E. Wozniak, L.L. Gee, M.S. Wachtel, Е.Е. Frezza // Dig. Pis. Sci. - 2008. - Dec. 4.
26. Yej J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance // Int. J. Obes. (Lond.). - 2008. - Dec. 9. [Epub ahead of print]
27. Zhang Y., Proenca R. et al. // Nature. - 1994. - Vol. 372. - P. 425-32.
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Soderzhanie leptina i pokazateli uglevodnogoobmena u bol'nykh ozhireniem posledieto-refleksoterapii. Obesity and metabolism. 2009;6(4):34-37. (In Russ.) https://doi.org/10.14341/2071-8713-4876
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