Preview

Obesity and metabolism

Advanced search

Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity

https://doi.org/10.14341/2071-8713-4821

Abstract

The aim of this study was to compare hormonal, anthropometric and metabolic parameters in men of the komi ethnic group with (n=23, BMI ≥25 kg/м2) or without (n=39, 18.4≤BMI <25 kg/м2) obesity. Totally 62 males living in Komi Republic were included in the study. It has been established that obesity was accompanied by an increase in serum concentrations of cholesterol and low density lipoprotein cholesterol in comparison with control group indicating metabolic disturbance. The data shows the significant effect of BMI on testosterone and FSH serum concentration, but not on LH, estradiol, thyrotrophic hormone, thyroxin and triiodthyronin levels. Overweight and obese men had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in overweight and obese men can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido and alteration in spermatogenesis

About the Authors

L Osadchuk

doktor biologicheskikh nauk, vedushchiy nauchnyy sotrudnik


N Gutorova

professor, kandidat biologicheskikh nauk, inzhener-issledovatel'


A Ludinina

kandidat biologicheskikh nauk, nauchnyy sotrudnik


N Potolitsyna

kandidat biologicheskikh nauk, vedushchiy nauchnyy sotrudnik


E Bojko

doktor meditsinskikh nauk, zaveduyushchiy otdelom ekologicheskoy i meditsinskoy fiziologii


References

1. Бойко Е.Р., Бичкаева Ф.А., Ткачев А.В., Догадин С.А. Особенности регуляции метаболических путей у разных групп аборигенного населения европейского Севера. Физиология человека 1997; 23 (№ 4): 95–97.

2. Бойко Е.П., Максимов А.Л., Годовых Т.В., Бичкаева Ф.А. Основные аспекты метаболической адаптации человека на Севере. «Человек на Севере: системные механизмы адаптации». Магадан: СВНЦ ДВО РАН. 2007. С. 173–188.

3. Бойко Е.Р., Канева А.М. Апопротеин Е и его значение в клинической физиологии. Успехи физиологических наук 2009; 40 (№ 1): 3–15.

4. Гончаров Н.П., Кация Г.В., Чагина Н.А. Ожирение и метаболический синдром у мужчин среднего возраста: сравнительный анализ андрогенного статуса, антропометрических показателей, липидного спектра, показателей углеводного обмена. Андрология и генитальная хирургия 2007; № 1: 6–13.

5. Осадчук Л.В., Попова А.В., Туманик О.В., Суботялов М.А., Айзман Р.И. Андрогенный дефицит у мужчин с избыточной массой тела и ожирением // Проблемы репродукции 2012; 18 (№ 4): 76–79.

6. Попова А.В., Осадчук Л.В. Связь ожирения с основными репродуктивными показателями у мужчин – жителей Новосибирска. Ожирение и метаболизм 2012; № 4: 34–38.

7. Проблемы адаптации человека к экологическим и социальным условиям Севера. Под ред. Е.Р. Бойко. Сыктывкар – С.-Петербург: Политехника-сервис. 2009. 264 с.

8. Шварц В. Жировая ткань как эндокринный орган. Проблемы эндокринологии 2009; 55 (№ 1): 38–50.

9. Aggerholm A.S., Thulstrup A.M., Toft G., Ramlau-Hansen C.H., Bonde J.P. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril 2008; 90: 619–626.

10. Bacon C.G., Mittleman M.A., Kawachi I., Giovannucci E., Glasser D.B., Rimm E.B. A prospective study of risk factors for erectile dysfunction. J Urol 2006; 176: 217–221.

11. Bakos H.W., Henshaw R.C., Mitchell M., Lane M. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril 2011; 95: 1700–1704.

12. Braeckman L., De Bacquer D., Rosseneu M., De Backer G. The effect of age and lifestyle factors on plasma levels of apolipoprotein E. J Cardiovasc Risk 1998; 5: 155–159.

13. Brand J.S, van der Tweel I., Grobbee D.E., Emmelot-Vonk M.H., van der Schouw Y.T. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol 2011; 40: 189–207.

14. Cabler S., Agarwal A., Flint M., Du Plessis S.S. Obesity: modern man’s fertility nemesis. Asian J Androl 2010; 12: 480–489.

15. Chavarro J.E., Toth T.L., Wright D.L. Meeker J.D., Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2010; 93: 2222–2231.

16. Cunningham M.J., Clifton D.K., Steiner R.A. Leptin’s actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999; 60: 216–222.

17. Esposito K., Giugliano F., Di Palo C., Giugliano G., Marfella R., D'Andrea F., D'Armiento M., Giugliano D. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004; 291: 2978–2984.

18. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502.

19. Haffner S.M., Valdez R.A., Stern M.P., Katz M.S. Obesity, body fat distribution and sex hormones in men. Int J Obes Relat Metab Disord 1993; 17 (11): 643–649.

20. Hammoud A.O., Carrell D.T., Gibson M., Peterson C.M., Meikle A.W. Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest. Asian J Androl 2012; 14: 77–81.

21. Jensen T.K., Andersson A.M., Jørgensen N. Andersen A.G., Carlsen E., Petersen J.H., Skakkebaek N.E. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004; 82: 863–870.

22. Kasturi S.S., Tannir J., Brannigan R.E. The metabolic syndrome and male infertility. J Androl 2008; 29: 251–259.

23. Kort H.I., Massey J.B., Elsner C.W., Mitchell-Leef D., Shapiro D.B., Witt M.A., Roudebush W.E. Impact of body mass index values on sperm quantity and quality. J Androl 2006; 27: 450–452.

24. Kreisberg R.A., Kasim S. Cholesterol metabolism and aging. Am J Med 1987; 82: 54–60.

25. Kupelian V., Hayes F.J., Link C.L., Rosen R., McKinlay J.B. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab 2008; 93: 3403–3410.

26. Martins I.J., Redgrave T.G. Obesity and post-prandial lipid metabolism. Feast or famine? J Nutr Biochem 2004; 15: 130–141.

27. Nguyen R., Wilcox A., Skjaerven R., Baird D.D. Men’s body mass index and infertility. Hum Reprod 2007; 22: 2488–2483.

28. Nieschlag E., Simoni M., Gromoll J., Weinbauer G.F. Role of FSH in the regulation of spermatogenesis: clinical aspects. Clin Endocrinol 1999; 51: 139–146.

29. Ramlau-Hansen C.H., Thulstrup A.M., Nohr E.A., Bonde J.P., Sorensen T.I., Olsen J. Subfecundity in overweight and obese couples. Hum Reprod 2007; 22: 1634–1637.

30. Schaefer E.J., Lichtenstein A.H., Lamon-Fava S., McNamara J.R., Ordovas J.M. Lipoproteins, nutrition, aging, and atherosclerosis. Am J Clin Nutr 1995; 61 (3 Suppl): 726S–740S.

31. Tchernof A., Despres J.P. Pathophysiology of human visceral obesity: an update. Physiol Rev 2013; 93: 359–404.

32. Tchernof A., Labrie F., Bélanger A., Prud'homme D., Bouchard C., Tremblay A., Nadeau A., Després J.P. Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis 1997; 133: 235–244.

33. Toth M.J., Tchernof A. Lipid metabolism in the elderly. Eur J Clin Nutr 2000; 54.: 121–125.


Review

For citations:


 ,  ,  ,  ,   Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity. Obesity and metabolism. 2013;10(2):28-32. (In Russ.) https://doi.org/10.14341/2071-8713-4821

Views: 596


ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)