Особенности метаболизма витамина D при беременности

Витамин D играет важную роль в регуляции системы «мать-плацента-плод», участвуя в обеспечении нормального роста и развития плода, снижая риски гипокальциемии, мышечных судорог, инфекций дыхательных путей в детском возрасте. К настоящему времени установлено существование более 50 метаболитов витамина D, из которых наиболее изученными являются общий 25-гидроксивитамин D (25(ОН)D) и 1,25-дигидроксивитамин D (1,25(ОН)2D), что обус­ловлено, прежде всего, их важностью для эндокринной регуляции кальций-фосфорного обмена. Уровень 25(OH)D в крови представляет собой оптимальный, но не совершенный маркер обеспеченности витамином D, не отражает многочисленные эффекты его метаболитов. С учетом особой метаболической адаптации организма женщины в период гестации, анализ количественных изменений различных метаболитов витамина D представляет особую актуальность. В настоящем обзоре обобщены имеющиеся данные об особенностях метаболизма витамина D вне гестации и при беременности.

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