Differential diagnosis of idiopathic hypoparathyroidism: a case series
https://doi.org/10.14341/omet12726
Abstract
Idiopathic hypoparathyroidism is a rare endocrine disease diagnosed when all possible causes of hypoparathyroidism are excluded.
Data on the prevalence of idiopathic hypoparathyroidism is limited, there are several local studies in some countries. The variety and non-specificity of the hypoparathyroidism symptoms, similarity to other diseases (eg. epilepsy), causes the misdiagnosis and delay in pathogenetic therapy.
Idiopathic hypoparathyroidism is rare. Therefore, the absence of neck surgery in the anamnesis practically excludes hypoparathyroidism from the diagnostic search. Moreover, it is necessary to rule out all known causes of decreased PTH hypoparathyroidism to determine the form of non-surgical hypoparathyroidism.
We present a case series of idiopathic hypoparathyroidism, which demonstrates the difficulty in diagnosis, and the clinical features of the disease. The article covers also the problem of modern diagnostic approaches including the determination of the interferon-omega for patients with suspected autoimmune polyglandular syndrome type 1 as the most common cause of nonsurgical hypoparathyroidism.
About the Authors
T. M. Afonasyeva
Endocrinology Research Centre
Russian Federation
Russian Federation
Tatiana M. Afonasyeva, resident
Moscow
E. V. Kovaleva
Endocrinology Research Centre
Russian Federation
Russian Federation
Elena V. Kovaleva, MD
11 Dm. Ulyanova street, 117036 Moscow, Russia
A. K. Eremkina
Endocrinology Research Centre
Russian Federation
Russian Federation
Anna K. Eremkina, MD, PhD
Moscow
N. G. Mokrysheva
Endocrinology Research Centre
Russian Federation
Russian Federation
Natalia G. Mokrysheva, MD, PhD, Professor
Moscow
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1. Figure 1. Diagnostic search for idiopathic hypoparathyroidism [4]. | |
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2. Figure 2. Changes in clinical and laboratory parameters. | |
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For citations:
Afonasyeva T.M., Kovaleva E.V., Eremkina A.K., Mokrysheva N.G. Differential diagnosis of idiopathic hypoparathyroidism: a case series. Obesity and metabolism. 2021;18(3):276-281. (In Russ.) https://doi.org/10.14341/omet12726
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